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Central nervous system drugs

Propiomazine

Also known as Propionylpromethazine, Phenoctyl, Propiomazina

CAS 362-29-8Formula C20H24N2OSMolar mass 340.49 g/molEC 206-646-1
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment
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Propiomazine chemical structure, C20H24N2OS, CAS 362-29-8
2D chemical structure

Key facts

What buyers check first

All properties
Melting point
160 to 161
Boiling point
235 to 245
Solubility
SLOWLY OXIDIZED WHEN MOISTENED OR IN AQUEOUS SOLN ON PROLONGED EXPOSURE TO AIR &/OR LIGH…
HS code
293430
Category
Central nervous system drugs

What is Propiomazine?

Plain description, key identifiers and synonyms

Propiomazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2. It has a role as a sedative, a phenothiazine antipsychotic drug, a histamine antagonist, a serotonergic antagonist, a dopaminergic antagonist and a muscarinic antagonist. It is a member of phenothiazines, a tertiary amino compound and an aromatic ketone. It derives from a hydride of a 10H-phenothiazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
CAS number
362-29-8 CAS number cross-checked
EC number
206-646-1
Molecular formula
C20H24N2OS
UNII
242Z0PM79Y
InChIKey
UVOIBTBFPOZKGP-UHFFFAOYSA-N
InChI
InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3
SMILES (canonical and isomeric)
CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C

Synonyms

  • Propionylpromethazine
  • Phenoctyl
  • Propiomazina
  • Propiomazinum
  • Wy-1359
  • 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one
  • CB 1678
  • 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazine
  • 3-Propionyl-10-dimethylaminoisopropylphenothiazine
  • 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine
  • Dorevan
  • Propavan
  • Dorevane
  • Indorm
  • 10-Dimethylaminoisopropyl-2-propionylphenothiazine
  • 1-Propanone, 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)-
  • 1-Propanone, 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-
  • 1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
  • 2-Propionyl-10-[2-(dimethylamino)propyl]phenothiazine
  • 1-Propanone, 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-
  • 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)propan-1-one
  • (+-)-Propiomazine
  • 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
  • 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone
  • 1-(10-(2-(Dimethylamino)propyl)phenothiazin-2-yl)-1-propanone
Show all 31 synonyms
  • 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl]-1-propanone
  • 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone
  • Propiomazine (USAN/INN)
  • 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone
  • Propiomazine Free Base
  • Propiomazine, >96%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
160 to 161exp.
Boiling point
235 to 245exp.
Solubility
SLOWLY OXIDIZED WHEN MOISTENED OR IN AQUEOUS SOLN ON PROLONGED EXPOSURE TO AIR &/OR LIGHT, 1 G SOL IN 4.5 ML WATER, FREELY SOL IN ALCOHOL, INSOL IN BENZENE /HYDROCHLORIDE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
340.49 g/molcalc.
Exact mass
340.1609 Dacalc.
LogP (octanol/water)
4.83calc.
Topological polar surface area
23.55 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
5calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.35calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Nc1ccccc1S2

c1ccc2c(c1)Nc1ccccc1S2

3 rings, 14 atoms, the Phenothiazine ring system.

1,001 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Propiomazine suppliers

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Propiomazine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Roles

  • antagonist
  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • histamine antagonist
  • histaminergic drug
  • muscarinic antagonist
  • neurotransmitter agent
  • pharmaceutical
  • phenothiazine antipsychotic drug
  • psychotropic drug
  • sedative
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Propiomazine is a phenothiazine derivative and atypical antipsychotic agent with sedative, antiemetic and antipsychotic activities. Propiomazine binds to a variety of receptors, including alpha1, dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. Propiomazine exerts its antiemetic and sedative effects through antagonism at histamine H1 receptors, Its antipsychotic effect is attributed to antagonistic activities at dopamine and 5-HT2 receptors.

How it is made

Schmitt et al, bull soc chim france 1957, 1474, schmitt, french patent addn 71,342 (addn to french patent 1,176,919 to cli n-byla).

1-(Phenothiazin-2-yl)-1-propanone is condensed with 2-(dimethylamino)propyl chloride with the aid of a dehydrochlorinating agent such as sodamide. The propiomazine thus formed is dissolved in a suitable org solvent & reacted with an equimolar portion of hydrogen chloride to yield the salt. (Hydrochloride)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Propiomazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Propiomazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Propiomazine, based on the data on this page

What is Propiomazine?

Propiomazine is a member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2.

What is the CAS number of Propiomazine?

The CAS registry number of Propiomazine is 362-29-8.

What is the molecular formula and weight of Propiomazine?

The molecular formula of Propiomazine is C20H24N2OS and its molar mass is 340.49 g/mol.

What is Propiomazine used for?

Use classes: Pharmaceuticals.

Is Propiomazine hazardous?

Propiomazine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause an allergic skin reaction, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Propiomazine?

Propiomazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Propiomazine?

Post a free request on CompoundList and suppliers of Propiomazine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Propiomazine?

Suppliers quote Propiomazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Propiomazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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