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Flavonoids and polyphenols

Diosmetin

Also known as Luteolin 4'-methyl ether, 4'-Methylluteolin, Salinigricoflavonol

CAS 520-34-3Formula C16H12O6Molar mass 300.27 g/molEC 208-291-8
GHS signal word: Warning. Pictograms: Harmful or irritant 78 suppliers listed Drug substance
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Diosmetin chemical structure, C16H12O6, CAS 520-34-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Yellow powder
Melting point
256 to 258
Density
1.512 g/cm³
Solubility
Soluble in chloroform, dichloromethane, DMSO, acetone
HS code
293299
Category
Flavonoids and polyphenols
Illustrative photo, yellow pigment powder in a glass jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Diosmetin?

Plain description, key identifiers and synonyms

Diosmetin is a monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities. It has a role as a tropomyosin-related kinase B receptor agonist, an antioxidant, an antineoplastic agent, a vasodilator agent, an angiogenesis inhibitor, a bone density conservation agent, an anti-inflammatory agent, an apoptosis inducer, a plant metabolite and a cardioprotective agent. It is a monomethoxyflavone, a trihydroxyflavone and a 3'-hydroxyflavonoid. It is functionally related to a luteolin. It is a conjugate acid of a diosmetin-7-olate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
CAS number
520-34-3 CAS number cross-checked
EC number
208-291-8
Molecular formula
C16H12O6
UNII
TWZ37241OT
MDL number
MFCD00017425
INCI name
DIOSMETIN
InChIKey
MBNGWHIJMBWFHU-UHFFFAOYSA-N
InChI
InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
SMILES (canonical and isomeric)
COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

Synonyms

  • Luteolin 4'-methyl ether
  • 4'-Methylluteolin
  • Salinigricoflavonol
  • Diosmetine
  • 3',5,7-trihydroxy-4'-methoxyflavone
  • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
  • 5,7,3'-Trihydroxy-4'-methoxyflavone
  • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
  • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
  • 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-
  • Flavone, 3',5,7-trihydroxy-4'-methoxy-
  • Isaknox x202 whitening secret essence
  • Gongjinhyang seol whitening
  • Whoo Gongjinhyang Seol Whitening Jin Essence
  • Isa knox wxii plus whitening revolution serum
  • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
  • 5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chromen-4-one
  • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl), -4H-chromen-4-one
  • Diosmin EP Impurity F
  • Pillon
  • Luteolin 4-methyl ether
  • Diosmetol
  • disometin
  • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (Diosmetin)
  • Diosmetin (Standard)
Show all 30 synonyms
  • 3',5,7-trihydroxy-4'-methoxy flavone
  • 4'-O-methyl-luteolin
  • Diosmetin, analytical standard
  • DivK1c_006531
  • Salinigricoflavonol, Vitamin P

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow powderexp.
Melting point
256 to 258exp.
Density
1.512 g/cm³exp.
Solubility
Soluble in chloroform, dichloromethane, DMSO, acetoneexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
300.27 g/molcalc.
Exact mass
300.0634 Dacalc.
LogP (octanol/water)
2.59calc.
Topological polar surface area
100.1 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
2calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.06calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2ccccc12

O=c1cc(-c2ccccc2)oc2ccccc12

3 rings, 17 atoms, the Flavone ring system.

2,273 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Diosmetin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 78 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

78 suppliers in 15 countries

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Diosmetin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Has use in reference standards, pharmacological research, food research, cosmetic research, synthetic precursor compounds, intermediates and fine chemicals, and as an ingredient in food supplements and beverages.

Pharmacology use as a natural flavonoid that can inhibit the activity of human CYP1A enzyme have antimutagenic and anti-allergic characters.

Aldose-Reductase-Inhibitor, Antimutagenic, Antirhinoviral, Antiviral, Cancer-Preventative.

Cosmetic ingredient, INCI name DIOSMETIN(skin conditioning)

Roles

  • agonist
  • angiogenesis inhibitor
  • anti-inflammatory agent
  • antineoplastic agent
  • antioxidant
  • apoptosis inducer
  • bone density conservation agent
  • cardioprotective agent
  • cardiovascular drug
  • eukaryotic metabolite
  • metabolite
  • pharmaceutical
  • plant metabolite
  • protective agent
  • tropomyosin-related kinase B receptor agonist
  • vasodilator agent

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

How it is made

Prepared from diosmin isolated from various plants sources.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diosmetin is traded under.

HS 2932.99Indicative HS code

Heterocyclic compounds with oxygen hetero-atom(s) only, other

World exports in 2024
$3.81B
+10.3% vs 2023, imports $7.05B
2019 to 2024
Top exporters
  1. China28.9%
  2. Switzerland * partner reported12.7%
  3. Germany7.8%
Top importers
  1. United States49.7%
  2. China11.9%
  3. India * partner reported3.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Diosmetin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diosmetin, based on the data on this page

What is Diosmetin?

Diosmetin is a monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities.

What is the CAS number of Diosmetin?

The CAS registry number of Diosmetin is 520-34-3.

What is the molecular formula and weight of Diosmetin?

The molecular formula of Diosmetin is C16H12O6 and its molar mass is 300.27 g/mol.

What is Diosmetin used for?

Has use in reference standards, pharmacological research, food research, cosmetic research, synthetic precursor compounds, intermediates and fine chemicals, and as an ingredient in food supplements and beverages.

Is Diosmetin hazardous?

Diosmetin carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Diosmetin?

Diosmetin is usually classified under HS code 293299 (Heterocyclic compounds with oxygen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diosmetin?

CompoundList lists 78 suppliers of Diosmetin in China, United States, United Kingdom, Hong Kong and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diosmetin in India?

1 supplier in India list Diosmetin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diosmetin?

Suppliers quote Diosmetin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diosmetin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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