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Dye intermediates

Mci-186

Also known as MCI 186, edaravone, 3-Methyl-1-phenyl-2-pyrazolin-5-one

CAS 89-25-8Formula C10H10N2OMolar mass 174.20 g/molEC 201-891-0
GHS signal word: Warning. Pictograms: Harmful or irritant 145 suppliers listed
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Mci-186 chemical structure, C10H10N2O, CAS 89-25-8
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Monoclinic prisms from water
Melting point
127 °C
Boiling point
191 °C
Solubility
SOL IN HOT WATER & HOT ALCOHOL, SLIGHTLY SOL IN BENZENE, INSOL IN PETROLEUM ETHER
HS code
293319
Category
Dye intermediates
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Mci-186?

Plain description, key identifiers and synonyms

Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. It has a role as an antioxidant and a radical scavenger.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-methyl-2-phenyl-4H-pyrazol-3-one
CAS number
89-25-8 CAS number cross-checkedOther or deprecated CAS: 19735-89-8
EC number
201-891-0
Molecular formula
C10H10N2O
UNII
S798V6YJRP
MDL number
MFCD00003138
INCI name
PHENYL METHYL PYRAZOLONE
InChIKey
QELUYTUMUWHWMC-UHFFFAOYSA-N
InChI
InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
SMILES (canonical and isomeric)
CC1=NN(C(=O)C1)C2=CC=CC=C2

Synonyms

  • MCI 186
  • edaravone
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one
  • Radicut
  • Norphenazone
  • 1-Phenyl-3-methyl-5-pyrazolone
  • Developer Z
  • Methylphenylpyrazolone
  • Norantipyrine
  • C.I. Developer 1
  • Phenylmethylpyrazolone
  • Phenyl methyl pyrazolone
  • Radicava
  • 3-Methyl-1-phenyl-5-pyrazolone
  • 3-Methyl-1-phenyl-1H-pyrazol-5(4H)-one
  • 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
  • 5-methyl-2-phenyl-4H-pyrazol-3-one
  • 3-Methyl-1-phenyl-2-pyrazoline-5-one
  • 1-Phenyl-3-methyl-5-oxo-2-pyrazoline
  • 3H-Pyrazol-3-one, 2,4-dihydro-5-methyl-2-phenyl-
  • 1-Phenyl-3-methylpyrazolone
  • 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
  • 1-Phenyl-3-methylpyrazolone-5
  • 2,4-Dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
  • 3-Methyl-1-phenylpyrazol-5-one
Show all 37 synonyms
  • 5-Pyrazolone, 3-methyl-1-phenyl-
  • Colorex pmp
  • Jarocol pmp
  • Edaravone (MCI-186)
  • 1-Fenyl-3-methyl-2-pyrazolin-5-on
  • 3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
  • 1-Phenyl-3-methyl-5-pyrazolinone
  • 3-Methyl-1-phenyl-2-pyrazolin-5-one (mci-186)
  • CI Developer 1
  • Monopyrazolone
  • 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one (Edaravone)
  • Radicut (TN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Monoclinic prisms from waterexp.
Melting point
127 °Cexp.
Boiling point
191 °Cexp.
Solubility
SOL IN HOT WATER & HOT ALCOHOL, SLIGHTLY SOL IN BENZENE, INSOL IN PETROLEUM ETHERexp.
Vapour pressure
LESS THAN 0.01 MM @ 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
174.20 g/molcalc.
Exact mass
174.0793 Dacalc.
LogP (octanol/water)
1.8calc.
Topological polar surface area
32.67 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
13calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC=NN1c1ccccc1

O=C1CC=NN1c1ccccc1

2 rings, 12 atoms, the 1-Phenyl-1H-pyrazol-5(4H)-one ring system.

416 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (22)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Mci-186 suppliers

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Where suppliers are based

145 suppliers in 19 countries

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Mci-186 price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Intermediate for dyes & drugs, sensitive reagent for detection of cyanide.

Chemical intermediate for dyes (eg, for pyrazolone pigments), drugs (eg, antipyrine & aminopyrine), developer for diazotised direct dyes, reagent for detection of cyanide.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name PHENYL METHYL PYRAZOLONE(hair dyeing)

Roles

  • antioxidant
  • neuroprotective agent
  • pharmaceutical
  • protective agent
  • radical scavenger
  • renoprotective agent

Functional uses

  • Dye

Cosmetic functions

  • Hair dyeing

Pharmacology

Edaravone is a free radical scavenger and neuroprotective agent used for therapy of amyotrophic lateral sclerosis. Edaravone is associated with a low rate of serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent, acute liver injury.

How it is made

Condensation of phenylhydrazine with ethyl acetoacetate

By condensation of phenylhydrazine with ethylacetoacetate.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex III, restricted in cosmetics
    Name: PHENYL METHYL PYRAZOLONE, Ref no: 228, Annex ref: III/228

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mci-186 is traded under.

HS 2933.19Indicative HS code

Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…

World exports in 2024
$3.44B
−22.6% vs 2023, imports $6.66B
2019 to 2024
Top exporters
  1. China21.6%
  2. Switzerland * partner reported20.5%
  3. Germany19.0%
Top importers
  1. Slovenia38.4%
  2. Portugal14.1%
  3. Brazil13.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mci-186 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mci-186, based on the data on this page

What is Mci-186?

Edaravone is a pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively. It has a role as an antioxidant and a radical scavenger.

What is the CAS number of Mci-186?

The CAS registry number of Mci-186 is 89-25-8. Other or deprecated CAS numbers: 19735-89-8.

What is the molecular formula and weight of Mci-186?

The molecular formula of Mci-186 is C10H10N2O and its molar mass is 174.20 g/mol.

What is Mci-186 used for?

Intermediate for dyes & drugs, sensitive reagent for detection of cyanide. Chemical intermediate for dyes (eg, for pyrazolone pigments), drugs (eg, antipyrine & aminopyrine), developer for diazotised direct dyes, reagent for detection of cyanide. Use classes: Cosmetics.

Is Mci-186 hazardous?

Mci-186 carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Mci-186?

Mci-186 is usually classified under HS code 293319 (Compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mci-186?

CompoundList lists 145 suppliers of Mci-186 in United States, China, India, Japan and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Mci-186 in India?

21 suppliers in India list Mci-186 on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Mci-186?

Suppliers quote Mci-186 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mci-186

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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