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Heterocyclic building blocks

Methaqualone

Also known as Metolquizolone, Methaqualoneinone, Metaqualon

CAS 72-44-6Formula C16H14N2OMolar mass 250.30 g/molEC 200-780-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe) Prohibited, not for trade
Why it is not for trade
Methaqualone chemical structure, C16H14N2O, CAS 72-44-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
120 °C
Solubility
PRACTICALLY INSOL IN WATER
HS code
293355
Category
Heterocyclic building blocks

What is Methaqualone?

Plain description, key identifiers and synonyms

Methaqualone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2 and 3 by methyl and o-tolyl groups respectively. A depressant that increases the activity of the GABA receptors in the brain and nervous system, it is used as a sedative and hypnotic medication. It became popular as a recreational drug and club drug in the late 1960s and 1970s. It has a role as a sedative and a GABA agonist.

Methaqualone is a psychoactive pharmaceutical.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-methyl-3-(2-methylphenyl)quinazolin-4-one
CAS number
72-44-6 CAS number cross-checked
EC number
200-780-4
Molecular formula
C16H14N2O
UNII
7ZKH8MQW6T
InChIKey
JEYCTXHKTXCGPB-UHFFFAOYSA-N
InChI
InChI=1S/C16H14N2O/c1-11-7-3-6-10-15(11)18-12(2)17-14-9-5-4-8-13(14)16(18)19/h3-10H,1-2H3
SMILES (canonical and isomeric)
CC1=CC=CC=C1N2C(=NC3=CC=CC=C3C2=O)C

Synonyms

  • Metolquizolone
  • Methaqualoneinone
  • Metaqualon
  • Quaalude
  • Tuazolone
  • Cateudyl
  • Hyminal
  • Melsomin
  • Ortonal
  • Dormigoa
  • Dormogen
  • Dormutil
  • Dorsedin
  • Fadormir
  • Holodorm
  • Mollinox
  • Mozambin
  • Nobedorm
  • Noctilene
  • Optinoxan
  • Orthonal
  • Parminal
  • Rouqualone
  • Sindesvel
  • Somberol
Show all 39 synonyms
  • Somnomed
  • Hyptor
  • Ipnofil
  • Motolon
  • Roulone
  • Soverin
  • Torinal
  • Omnyl
  • Sonal
  • Sopor
  • Hyptor base
  • Normi-Nox
  • Citexal
  • Mequin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Odour
LITTLE OR NO ODORexp.
Taste
BITTER TASTEexp.
Melting point
120 °Cexp.
Solubility
PRACTICALLY INSOL IN WATERexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
250.30 g/molcalc.
Exact mass
250.1106 Dacalc.
LogP (octanol/water)
3calc.
Topological polar surface area
34.89 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
19calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1c2ccccc2ncn1-c1ccccc1

O=c1c2ccccc2ncn1-c1ccccc1

3 rings, 17 atoms, the 3-Phenyl-3H-quinazolin-4-one ring system.

982 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (8)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methaqualone suppliers

Trading restrictions apply to this substance

Psychotropic substance

Methaqualone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.55 (loprazolam, mecloqualone, methaqualone and zipeprol)

Our policy on controlled substances

Methaqualone price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Hypnotics and Sedatives

Roles

  • GABA agent
  • GABA agonist
  • central nervous system depressant
  • central nervous system drug
  • neurotransmitter agent
  • pharmaceutical
  • sedative

Pharmacology

Methaqualone is a sedative, hypnotic agent that was used for insomnia, but was taken off of the market, in the U.S., in 1983 due to its high risk of abuse.(NCI)

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Methaqualone is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.55 (loprazolam, mecloqualone, methaqualone and zipeprol)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methaqualone is traded under.

HS 2933.55Exact HS code

Loprazolam (INN), mecloqualone (INN), methaqualone (INN) and zipeprol (INN), salts thereof

World exports in 2024
$563K
+18.3% vs 2023, imports $1.56M
2019 to 2024
Top exporters
  1. India * partner reported45.4%
  2. France * partner reported33.4%
  3. United Kingdom10.0%
Top importers
  1. Poland32.6%
  2. Egypt26.2%
  3. Colombia12.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methaqualone is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methaqualone, based on the data on this page

What is Methaqualone?

Methaqualone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2 and 3 by methyl and o-tolyl groups respectively. A depressant that increases the activity of the GABA receptors in the brain and nervous system, it is used as a sedative and hypnotic medication.

What is the CAS number of Methaqualone?

The CAS registry number of Methaqualone is 72-44-6.

What is the molecular formula and weight of Methaqualone?

The molecular formula of Methaqualone is C16H14N2O and its molar mass is 250.30 g/mol.

What is Methaqualone used for?

Use classes: Pharmaceuticals.

Is Methaqualone hazardous?

Methaqualone carries the GHS signal word "Danger". Main hazards: toxic if swallowed, may cause long lasting harmful effects to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methaqualone?

Methaqualone is usually classified under HS code 293355 (Loprazolam (INN), mecloqualone (INN), methaqualone (INN) and zipeprol (INN), salts thereof). This is indicative, confirm it with your customs broker before shipping.

Can I buy Methaqualone on CompoundList?

No. Methaqualone is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Methaqualone

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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