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Heterocyclic building blocks

Methdilazine

Also known as Tacaryl, Methdilazinum, Tacazyl

CAS 1982-37-2Formula C18H20N2SMolar mass 296.44 g/molEC 217-841-6
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Methdilazine chemical structure, C18H20N2S, CAS 1982-37-2
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Crystals
Melting point
87.2 to 87.8 °C
HS code
293430
Category
Heterocyclic building blocks
UN number
UN 2811
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Methdilazine?

Plain description, key identifiers and synonyms

Methdilazine is a phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group, a first-generation antihistamine with anticholinergic properties. It has a role as a histamine antagonist, a cholinergic antagonist and an antipruritic drug. It is a member of phenothiazines and a N-alkylpyrrolidine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine
CAS number
1982-37-2 CAS number cross-checkedOther or deprecated CAS: 1229-35-2
EC number
217-841-6
Molecular formula
C18H20N2S
UNII
4Q13LY9Z8X
InChIKey
HTMIBDQKFHUPSX-UHFFFAOYSA-N
InChI
InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
SMILES (canonical and isomeric)
CN1CCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42

Synonyms

  • Tacaryl
  • Methdilazinum
  • Tacazyl
  • Metodilazina
  • Dilosyn
  • metdilazina
  • 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine
  • 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine
  • 10-[(1-Methyl-3-Pyrrolidinyl)methyl]phenothiazine
  • Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-
  • Phenothiazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]-
  • 10-((1-methylpyrrolidin-3-yl)methyl)-10H-phenothiazine
  • 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine
  • Methdilazine (INN)
  • Methodilazine
  • 10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-
  • 10H-Phenothiazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]-
  • Tacryl
  • 10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine, MJ 5022
  • Tacaryl (TN)
  • Methdilazine (200 mg)
  • Dilosyn (Salt/Mix)
  • Disyncram (Salt/Mix)
  • Disyncran (Salt/Mix)
  • 10-((1-methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine
Show all 28 synonyms
  • 10H-Phenothiazine, tannate (5:1)
  • PDSP1_000149
  • PDSP2_000148

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Crystalsexp.
Melting point
87.2 to 87.8 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
296.44 g/molcalc.
Exact mass
296.1347 Dacalc.
LogP (octanol/water)
4.24calc.
Topological polar surface area
6.48 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
21calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Sc1ccccc1N2CC1CCNC1

c1ccc2c(c1)Sc1ccccc1N2CC1CCNC1

4 rings, 20 atoms.

6 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methdilazine suppliers

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Methdilazine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antagonist
  • antipruritic drug
  • cholinergic antagonist
  • cholinergic drug
  • dermatologic drug
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methdilazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methdilazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methdilazine, based on the data on this page

What is Methdilazine?

Methdilazine is a phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group, a first-generation antihistamine with anticholinergic properties. It has a role as a histamine antagonist, a cholinergic antagonist and an antipruritic drug. It is a member of phenothiazines and a N-alkylpyrrolidine.

What is the CAS number of Methdilazine?

The CAS registry number of Methdilazine is 1982-37-2. Other or deprecated CAS numbers: 1229-35-2.

What is the molecular formula and weight of Methdilazine?

The molecular formula of Methdilazine is C18H20N2S and its molar mass is 296.44 g/mol.

What is Methdilazine used for?

Known uses and roles of Methdilazine include building blocks in research and laboratory, screening compounds in research and laboratory, antagonist, antipruritic drug, cholinergic antagonist and 6 more.

Is Methdilazine hazardous?

No GHS hazard classification for Methdilazine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Methdilazine?

Methdilazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methdilazine?

Post a free request on CompoundList and suppliers of Methdilazine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Methdilazine?

Suppliers quote Methdilazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methdilazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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