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Aliphatic and alicyclic building blocks

Mitoguazone

Also known as MGBG, Methyl-Gag, Mitoguazona

CAS 459-86-9Formula C5H12N8Molar mass 184.21 g/molEC 610-278-0
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Mitoguazone chemical structure, C5H12N8, CAS 459-86-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
459-86-9
Formula
C5H12N8
Molar mass
184.21 g/mol
Solubility
0.1 N NaOH soluble (mg/mL)
HS code
292529
Category
Aliphatic and alicyclic building blocks

What is Mitoguazone?

Plain description, key identifiers and synonyms

Mitoguazone is a hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor. It is a member of guanidines and a hydrazone. It is functionally related to a methylglyoxal and an aminoguanidine. It is a conjugate base of a mitoguazone(2+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine
CAS number
459-86-9 CAS number cross-checked
EC number
610-278-0
Molecular formula
C5H12N8
MDL number
MFCD00067519
InChIKey
MXWHMTNPTTVWDM-NXOFHUPFSA-N
InChI
InChI=1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+
Canonical SMILES
CC(C=NN=C(N)N)=NN=C(N)N
Isomeric SMILES
C/C(=N\N=C(N)N)/C=N/N=C(N)N

Synonyms

  • MGBG
  • Methyl-Gag
  • Mitoguazona
  • Me-GAG
  • Mitoguazonum
  • Methyl-G
  • Zyrkamine
  • Methylglyoxal bis(amidinohydrazone)
  • Methyl GAG
  • Methylglyoxal bis(guanylhydrazone)
  • 1,1'-((Methylethanediylidene)dinitrilo)diguanidine
  • Methylgag
  • Hydrazinecarboximidamide, 2,2'-(1-methyl-1,2-ethanediylidene)bis-
  • methylglyoxal bisguanylhydrazone
  • 2,2\"-(methyl-1,2-ethanediylidene)bis(hydrazinecarboximidamide)
  • N''-((E)-((1E)-1-(((diaminomethylidene)amino)imino)propan-2-ylidene)amino)guanidine
  • Pyruvaldehyde bis(amidinohydrazone)
  • Guanylhydrazone
  • 2-[(E)-[(1E)-1-(diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine
  • (2E,2'E)-2,2'-(1E,2E)-propane-1,2-diylidenedihydrazinecarboximidamide
  • Methylglyoxal bis-(guanylhydrazone)
  • 2,2'-(1-Methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide]
  • methylglyoxalbis(guanylhydrazone)
  • methylglyoxalbisguanylhydrazone
  • Win-10708-2
Show all 30 synonyms
  • 2-[(E)-[(2E)-2-(diaminomethylenehydrazono)-1-methyl-ethylidene]amino]guanidine
  • 1-[(E)-[(2E)-2-(carbamimidoylhydrazono)-1-methyl-ethylidene]amino]guanidine
  • N''''-{2-[(diaminomethylene)hydrazono]-1-methylethylidene}carbonohydrazonic diamide
  • (2E)-2-((2E)-2-{[(E)-amino(imino)methyl]hydrazono}-1-methylethylidene)hydrazinecarboximidamide
  • (2E)-2-((2E)-2-{[(Z)-amino(imino)methyl]hydrazono}-1-methylethylidene)hydrazinecarboximidamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
0.1 N NaOH soluble (mg/mL)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
184.21 g/molcalc.
Exact mass
184.1185 Dacalc.
LogP (octanol/water)
-2.11calc.
Topological polar surface area
153.5 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
13calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.2calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Mitoguazone suppliers

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All 2 suppliers

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Where suppliers are based

2 suppliers in 2 countries

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Mitoguazone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Enzyme Inhibitors

Roles

  • antineoplastic agent
  • apoptosis inducer
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04)

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Mitoguazone is traded under.

HS 2925.29Indicative HS code

Imines and their derivatives, salts thereof, other

World exports in 2024
$1.8B
+12.4% vs 2023, imports $1.84B
2019 to 2024
Top exporters
  1. China35.9%
  2. France * partner reported15.5%
  3. Germany9.1%
Top importers
  1. United States13.3%
  2. China13.0%
  3. Brazil9.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Mitoguazone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Mitoguazone, based on the data on this page

What is Mitoguazone?

Mitoguazone is a hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor.

What is the CAS number of Mitoguazone?

The CAS registry number of Mitoguazone is 459-86-9.

What is the molecular formula and weight of Mitoguazone?

The molecular formula of Mitoguazone is C5H12N8 and its molar mass is 184.21 g/mol.

What is Mitoguazone used for?

Known uses and roles of Mitoguazone include building blocks in research and laboratory, biochemical and pharmacological tools in research and laboratory, antineoplastic agent, apoptosis inducer, enzyme inhibitor and 3 more.

Is Mitoguazone hazardous?

No GHS hazard classification for Mitoguazone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Mitoguazone?

Mitoguazone is usually classified under HS code 292529 (Imines and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Mitoguazone?

CompoundList lists 2 suppliers of Mitoguazone in China and Ukraine. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Mitoguazone?

Suppliers quote Mitoguazone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Mitoguazone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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