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Aromatic building blocks

Monobenzone

Also known as 4-(Benzyloxy)phenol, Hydroquinone monobenzyl ether, Benoquin

CAS 103-16-2Formula C13H12O2Molar mass 200.24 g/molEC 203-083-3
GHS signal word: Warning. Pictograms: Harmful or irritant 49 suppliers listed
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Monobenzone chemical structure, C13H12O2, CAS 103-16-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Lustrous leaflets from water
Melting point
122.5 °C
Density
1.26
Solubility
SOLUBILITY IN BOILNG WATER ABOUT 1.0 G/100 ML, SOL IN ALC, ETHER, BENZENE
HS code
290950
Category
Aromatic building blocks
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Monobenzone?

Plain description, key identifiers and synonyms

Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a dermatologic drug, an allergen and a melanin synthesis inhibitor. It is functionally related to a hydroquinone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-phenylmethoxyphenol
CAS number
103-16-2 CAS number cross-checked
EC number
203-083-3
Molecular formula
C13H12O2
UNII
9L2KA76MG5
MDL number
MFCD00002333
InChIKey
VYQNWZOUAUKGHI-UHFFFAOYSA-N
InChI
InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2
SMILES (canonical and isomeric)
C1=CC=C(C=C1)COC2=CC=C(C=C2)O

Synonyms

  • 4-(Benzyloxy)phenol
  • Hydroquinone monobenzyl ether
  • Benoquin
  • p-(Benzyloxy)phenol
  • Benzoquin
  • Depigman
  • Leucodinine
  • Monobenzon
  • Monobenzyl hydroquinone
  • Superlite
  • Pigmex
  • Agerite alba
  • 4-(Phenylmethoxy)phenol
  • 4-(Benzyloxyl)phenol
  • Hydroquinone benzyl ether
  • Dermochinona
  • Carmifal
  • p-Hydroxyphenyl benzyl ether
  • Alba-Dome
  • Phenol, 4-(phenylmethoxy)-
  • Benzyl p-hydroxyphenyl ether
  • Monobenzyl ether hydroquinone
  • Monobenzona
  • Monobenzonum
  • Superlite (antioxidant)
Show all 35 synonyms
  • Benzylhydroquinone
  • Hydrochinon monobenzylether
  • p-Benzyloxyphenol
  • Monobenzyl Ether of Hydroquinone
  • 4-Benzyloxy-phenol
  • 4-Benzyloxyphenol
  • 4-phenylmethoxyphenol
  • Benzyl hydroquinone
  • Alba
  • 4-phenylmethoxy-phenol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Lustrous leaflets from waterexp.
Odour
ODORLESSexp.
Melting point
122.5 °Cexp.
Density
1.26exp.
Solubility
SOLUBILITY IN BOILNG WATER ABOUT 1.0 G/100 ML, SOL IN ALC, ETHER, BENZENEexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
200.24 g/molcalc.
Exact mass
200.0837 Dacalc.
LogP (octanol/water)
2.97calc.
Topological polar surface area
29.46 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
15calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.08calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(COc2ccccc2)cc1

c1ccc(COc2ccccc2)cc1

2 rings, 14 atoms, the Benzyl phenyl ether ring system.

10,771 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
Precautionary statements (11)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Monobenzone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 49 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

49 suppliers in 10 countries

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Monobenzone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Antioxidant for paraffins and polyvinyl chloride, polypropylene and polypropylene oxide, chemical intermediate in organic synthesis.

Rubber antioxidant, stabilizer, polymerization inhibitor, chemical intermediate.

Veterinary medication:.

Roles

  • aetiopathogenetic role
  • allergen
  • depigmentation drug
  • dermatologic drug
  • melanin synthesis inhibitor
  • pharmaceutical

Pharmacology

Monobenzone is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by means of Depigmenting Activity.

How it is made

Reaction of sodium phenoxide with benzyl chloride, reaction of hydroquinone and benzyl bromide in alcoholic potassium hydroxide

Prepd in various ways. One method involves condensing sodium p-nitrophenolate with benzyl chloride to produce benzyl p-nitrophenyl ether followed by 1) reduction of nitro to amino, 2) diazotization of amino, & 3) hydrolytic decomp of diazonium cmpd to corresponding phenol.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 604-043-00-1

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: 4-Benzyloxyphenol and 4-ethoxyphenol, Ref no: 178, Annex ref: II/178

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Monobenzone is traded under.

HS 2909.50Indicative HS code

Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…

World exports in 2024
$284M
+11.9% vs 2023, imports $291M
2019 to 2024
Top exporters
  1. India * partner reported32.9%
  2. Indonesia17.7%
  3. France * partner reported11.2%
Top importers
  1. China20.7%
  2. United States12.0%
  3. Brazil6.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Monobenzone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Monobenzone, based on the data on this page

What is Monobenzone?

Monobenzone is the monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation. It has a role as a dermatologic drug, an allergen and a melanin synthesis inhibitor. It is functionally related to a hydroquinone.

What is the CAS number of Monobenzone?

The CAS registry number of Monobenzone is 103-16-2.

What is the molecular formula and weight of Monobenzone?

The molecular formula of Monobenzone is C13H12O2 and its molar mass is 200.24 g/mol.

What is Monobenzone used for?

Antioxidant for paraffins and polyvinyl chloride, polypropylene and polypropylene oxide, chemical intermediate in organic synthesis. Rubber antioxidant, stabilizer, polymerization inhibitor, chemical intermediate. Veterinary medication:.

Is Monobenzone hazardous?

Monobenzone carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Monobenzone?

Monobenzone is usually classified under HS code 290950 (Ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Monobenzone?

CompoundList lists 49 suppliers of Monobenzone in China, United States, India, Canada and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Monobenzone in India?

2 suppliers in India list Monobenzone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Monobenzone?

Suppliers quote Monobenzone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Monobenzone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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