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Central nervous system drugs

Nalmefene

Also known as Nalmetrene, Nalmefeno, Nalmefenum

CAS 55096-26-9Formula C21H25NO3Molar mass 339.44 g/molEC 637-223-3
GHS signal word: Warning. Pictograms: Harmful or irritant 33 suppliers listed Drug substance
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Nalmefene chemical structure, C21H25NO3, CAS 55096-26-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
55096-26-9
Formula
C21H25NO3
Appearance
Crystals from ethyl acetate
Melting point
105 to 110
HS code
293499
Category
Central nervous system drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Nalmefene?

Plain description, key identifiers and synonyms

Nalmefene is a morphinane alkaloid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
CAS number
55096-26-9 CAS number cross-checked
EC number
637-223-3
Molecular formula
C21H25NO3
UNII
TOV02TDP9I
InChIKey
WJBLNOPPDWQMCH-MBPVOVBZSA-N
InChI
InChI=1S/C21H25NO3/c1-12-6-7-21(24)16-10-14-4-5-15(23)18-17(14)20(21,19(12)25-18)8-9-22(16)11-13-2-3-13/h4-5,13,16,19,23-24H,1-3,6-11H2/t16-,19+,20+,21-/m1/s1
Canonical SMILES
C=C1CCC2(O)C3Cc4ccc(O)c5c4C2(CCN3CC2CC2)C1O5
Isomeric SMILES
C=C1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O

Synonyms

  • Nalmetrene
  • Nalmefeno
  • Nalmefenum
  • ORF 11676
  • ORF 1167
  • (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinon-3,14-diol
  • (1S,5R,13S,17S)-4-(cyclopropylmethyl)-14-methylidene-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7,9,11(18)-triene-10,17-diol
  • (1S,5R,13S,17S)-4-(cyclopropylmethyl)-14-methylidene-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18)-triene-10,17-diol
  • Selincro
  • Nalmetrenum
  • Nalmetreno
  • 17-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol
  • Selincro (TN)
  • JF 1
  • (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylidene-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
  • Alcofene
  • Arthene
  • Cervene
  • Incystene
  • Soberal
  • Cessal
  • Nalmefene (USAN/INN)
  • (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol,
  • 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
  • Revex (nalmefene hydrochloride)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from ethyl acetateexp.
Melting point
105 to 110exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
339.44 g/molcalc.
Exact mass
339.1834 Dacalc.
LogP (octanol/water)
2.51calc.
Topological polar surface area
52.93 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
25calc.
Rings
6calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.62calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1CCC2C3Cc4cccc5c4C2(CCN3CC2CC2)C1O5

C=C1CCC2C3Cc4cccc5c4C2(CCN3CC2CC2)C1O5

6 rings, 23 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nalmefene suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 33 suppliers
30 of 30 offers
  • Siegfried Barbera S.L.
    Spain, Barbera Del Valles ManufacturerUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • SpecGx LLC
    United States, Raleigh ManufacturerUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • Lundbeck Pharmaceuticals Italy SpA
    Italy, Padova ManufacturerUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • Chemtos
    United StatesUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • 3WAY Pharm Inc
    China, ShanghaiUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • AbaChemScene, LLC
    United States, Monmouth JunctionUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • Achemtek
    United States, WoburnUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • Aladdin Scientific
    United States, RiversideUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • Ambinter
    France, OrleansUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
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  • BioChemPartner
    China, ShangHaiUnclaimed profile
    NalmefeneGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

33 suppliers in 13 countries

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Nalmefene price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Is a pure opioid receptor antagonist ... used to reverse opioid intoxication and for the treatment of opioid dependence. The compound is in clinical development for the treatment of alcoholism, to support smoking cessation and to control pathological gambling.

Therapeutic category: Narcotic antagonist.

Industries and functions

Pharmacological actions

  • Narcotic Antagonists

Pharmacology

Nalmefene is an Opioid Antagonist. The mechanism of action of nalmefene is as an Opioid Antagonist.

How it is made

Nalmefene is synthesized by a Wittig reaction of naltrexone with triphenylmethylphosphonium bromide in DMSO under basic catalysis of NaH.

Preparation: J. Fishman, US 3814768 (1974 to M.J. Lewenstein)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nalmefene is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Nalmefene is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nalmefene, based on the data on this page

What is Nalmefene?

Nalmefene is a morphinane alkaloid.

What is the CAS number of Nalmefene?

The CAS registry number of Nalmefene is 55096-26-9.

What is the molecular formula and weight of Nalmefene?

The molecular formula of Nalmefene is C21H25NO3 and its molar mass is 339.44 g/mol.

What is Nalmefene used for?

Is a pure opioid receptor antagonist ... used to reverse opioid intoxication and for the treatment of opioid dependence. The compound is in clinical development for the treatment of alcoholism, to support smoking cessation and to control pathological gambling. Therapeutic category: Narcotic antagonist.

Is Nalmefene hazardous?

Nalmefene carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nalmefene?

Nalmefene is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nalmefene?

CompoundList lists 33 suppliers of Nalmefene in United States, China, United Kingdom, Canada and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Nalmefene?

Suppliers quote Nalmefene on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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