CompoundList
Sign in
Analgesics and anti-inflammatories

Nepafenac

Also known as 2-(2-Amino-3-benzoylphenyl)acetamide, Nevanac, 2-Amino-3-benzoylbenzeneacetamide

CAS 78281-72-8Formula C15H14N2O2Molar mass 254.29 g/molEC 682-241-7
GHS signal word: Warning. Pictograms: Hazardous to the environment 79 suppliers listed Drug substance
Get quotes Compare 79 suppliers
Nepafenac chemical structure, C15H14N2O2, CAS 78281-72-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
78281-72-8
Formula
C15H14N2O2
Molar mass
254.29 g/mol
EC number
682-241-7
HS code
292429
Category
Analgesics and anti-inflammatories

What is Nepafenac?

Plain description, key identifiers and synonyms

Nepafenac is a monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a prodrug, a cyclooxygenase 2 inhibitor and a cyclooxygenase 1 inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2-amino-3-benzoylphenyl)acetamide
CAS number
78281-72-8 CAS number cross-checked
EC number
682-241-7
Molecular formula
C15H14N2O2
UNII
0J9L7J6V8C
MDL number
MFCD08067732
InChIKey
QEFAQIPZVLVERP-UHFFFAOYSA-N
InChI
InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
SMILES (canonical and isomeric)
C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N

Synonyms

  • 2-(2-Amino-3-benzoylphenyl)acetamide
  • Nevanac
  • 2-Amino-3-benzoylbenzeneacetamide
  • Ilevro
  • nepafenaco
  • AL 6515
  • nepafenacum
  • 2-[2-amino-3-(benzoyl)phenyl]acetamide
  • Nepafenac (USAN:INN:BAN:JAN)
  • 2-(2-amino-3-(benzoyl)phenyl)acetamide
  • Benzeneacetamide, 2-amino-3-benzoyl-
  • AHR 9434
  • Nepafenac (JAN/USAN/INN)
  • AHR 9434, AL 6515
  • Nepafenac (mart.)
  • Amfenac amide
  • 2-amino-3-benzoyl-benzeneacetamide
  • Benzeneacetamide, 2-amino-3-benzoyl-, 2-Amino-3-benzoylbenzeneacetamide, AHR 9434, AL 6515, Nepafenac, Nevanac
  • Nevanac (TN)
  • Nepafenac (Standard)
  • 2-(2-amino-3-benzoyl-phenyl)acetamide
  • Nepafenac, >=98% (HPLC)
  • 2-Amino-3-benzoyl-phenylacetamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
254.29 g/molcalc.
Exact mass
254.1055 Dacalc.
LogP (octanol/water)
1.53calc.
Topological polar surface area
86.18 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(c1ccccc1)c1ccccc1

O=C(c1ccccc1)c1ccccc1

2 rings, 14 atoms, the Benzophenone ring system.

5,108 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H400Very toxic to aquatic life.
Precautionary statements (3)
  • P273Avoid release to the environment.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nepafenac suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 79 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

79 suppliers in 12 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Nepafenac price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents, Non-Steroidal

Roles

  • analgesic
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antirheumatic drug
  • cyclooxygenase 1 inhibitor
  • cyclooxygenase 2 inhibitor
  • enzyme inhibitor
  • non-narcotic analgesic
  • non-steroidal anti-inflammatory drug
  • ophthalmology drug
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Nepafenac is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nepafenac is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nepafenac is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nepafenac, based on the data on this page

What is Nepafenac?

Nepafenac is a monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery.

What is the CAS number of Nepafenac?

The CAS registry number of Nepafenac is 78281-72-8.

What is the molecular formula and weight of Nepafenac?

The molecular formula of Nepafenac is C15H14N2O2 and its molar mass is 254.29 g/mol.

What is Nepafenac used for?

Known uses and roles of Nepafenac include analgesics and antipyretics in pharmaceuticals, anti-inflammatories in pharmaceuticals, analgesic, anti-inflammatory agent, anti-inflammatory drug and 11 more.

Is Nepafenac hazardous?

Nepafenac carries the GHS signal word "Warning". Main hazards: very toxic to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nepafenac?

Nepafenac is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nepafenac?

CompoundList lists 79 suppliers of Nepafenac in China, United States, India, Germany and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nepafenac in India?

8 suppliers in India list Nepafenac on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nepafenac?

Suppliers quote Nepafenac on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nepafenac

Get quotes for Nepafenac

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Nepafenac
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Nepafenac with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/nepafenac-78281-72-8" title="Nepafenac structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Analgesics and anti-inflammatories or HS code 292429

79 suppliers
Free quotes, contact stays private
Get quotes