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Screening compounds

Nintedanib

Also known as Vargatef, Intedanib, BIBF-1120

CAS 656247-17-5Formula C31H33N5O4Molar mass 539.64 g/mol
48 suppliers listed
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Nintedanib chemical structure, C31H33N5O4, CAS 656247-17-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
656247-17-5
Formula
C31H33N5O4
Molar mass
539.64 g/mol
HS code
293359
Category
Screening compounds

What is Nintedanib?

Plain description, key identifiers and synonyms

Nintedanib is a member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer. It has a role as an antifibrotic agent, an antineoplastic agent, a tyrosine kinase inhibitor, an angiogenesis inhibitor, a fibroblast growth factor receptor antagonist and a vascular endothelial growth factor receptor antagonist. It is a methyl ester, an aromatic amine, a member of oxindoles, a N-alkylpiperazine, an enamine, an aromatic ester and an aromatic amide. It is a conjugate base of a nintedanib(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate
CAS number
656247-17-5Other or deprecated CAS: 1160294-26-7, 928326-83-4
Molecular formula
C31H33N5O4
UNII
G6HRD2P839
MDL number
MFCD11974012
InChIKey
CPMDPSXJELVGJG-UHFFFAOYSA-N
InChI
InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,33,38H,15-18,20H2,1-3H3
SMILES (canonical and isomeric)
CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O

Synonyms

  • Vargatef
  • Intedanib
  • BIBF-1120
  • BIBF 1120
  • BIBF1120
  • Nintedanib (BIBF 1120)
  • (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
  • (Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
  • Methyl (Z)-3-[[[4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl]amino](phenyl)methylene]-2-oxoindoline-6-carboxylate
  • methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate
  • Nintedanib D3
  • 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester
  • methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
  • Methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate
  • Ofev (TN)
  • (Z)-Methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)-phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
  • methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
  • Methyl (3Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1h-indole-6-carboxylate
  • methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
  • Nintedanib E-isomer
  • (E)-Nintedanib
  • Nintedanib (Standard)
  • BIBF1120,Vargatef
  • Nintedanib (free base)
  • Nintedanib (USAN/INN)
Show all 30 synonyms
  • BIBF1120 (Vargatef)
  • BIBF 1120 (Nintedanib)
  • Nintedanib (BIBF 1120)?
  • US10669235, Nintedanib
  • Nintedanib - Bio-X trade mark

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
539.64 g/molcalc.
Exact mass
539.2533 Dacalc.
LogP (octanol/water)
4.04calc.
Topological polar surface area
101.5 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
7calc.
Heavy atoms
40calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.26calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CN1CCNCC1)Nc1ccc(N=C(c2ccccc2)c2c[nH]c3ccccc23)cc1

O=C(CN1CCNCC1)Nc1ccc(N=C(c2ccccc2)c2c[nH]c3ccccc23)cc1

5 rings, 33 atoms.

17 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Nintedanib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 48 suppliers
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Where suppliers are based

48 suppliers in 10 countries

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Nintedanib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • angiogenesis inhibitor
  • antagonist
  • antifibrotic agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • enzyme inhibitor
  • fibroblast growth factor receptor antagonist
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor
  • vascular endothelial growth factor receptor antagonist

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nintedanib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nintedanib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nintedanib, based on the data on this page

What is Nintedanib?

Nintedanib is a member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.

What is the CAS number of Nintedanib?

The CAS registry number of Nintedanib is 656247-17-5. Other or deprecated CAS numbers: 1160294-26-7, 928326-83-4.

What is the molecular formula and weight of Nintedanib?

The molecular formula of Nintedanib is C31H33N5O4 and its molar mass is 539.64 g/mol.

What is Nintedanib used for?

Known uses and roles of Nintedanib include building blocks in research and laboratory, screening compounds in research and laboratory, angiogenesis inhibitor, antagonist, antifibrotic agent and 9 more.

Is Nintedanib hazardous?

No GHS hazard classification for Nintedanib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Nintedanib?

Nintedanib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nintedanib?

CompoundList lists 48 suppliers of Nintedanib in China, United States, India, Italy and 6 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nintedanib in India?

2 suppliers in India list Nintedanib on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nintedanib?

Suppliers quote Nintedanib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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