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Heterocyclic building blocks

Nitroxoline

Also known as 5-nitroquinolin-8-ol, 8-Hydroxy-5-nitroquinoline, 5-Nitro-8-quinolinol

CAS 4008-48-4Formula C9H6N2O3Molar mass 190.16 g/molEC 223-662-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 31 suppliers listed
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Nitroxoline chemical structure, C9H6N2O3, CAS 4008-48-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
4008-48-4
Formula
C9H6N2O3
Molar mass
190.16 g/mol
EC number
223-662-4
HS code
293349
Category
Heterocyclic building blocks

What is Nitroxoline?

Plain description, key identifiers and synonyms

Nitroxoline is a monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. It has a role as an antimicrobial agent, an antiinfective agent, an antifungal agent and a renal agent. It is a C-nitro compound and a monohydroxyquinoline.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-nitroquinolin-8-ol
CAS number
4008-48-4 CAS number cross-checked
EC number
223-662-4
Molecular formula
C9H6N2O3
UNII
A8M33244M6
MDL number
MFCD00006791
InChIKey
RJIWZDNTCBHXAL-UHFFFAOYSA-N
InChI
InChI=1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H
SMILES (canonical and isomeric)
C1=CC2=C(C=CC(=C2N=C1)O)[N+](=O)[O-]

Synonyms

  • 5-nitroquinolin-8-ol
  • 8-Hydroxy-5-nitroquinoline
  • 5-Nitro-8-quinolinol
  • 5-Nitro-8-hydroxyquinoline
  • 5-Nitrox
  • 5-Nitro-8-oxyquinoline
  • Nitroxolina
  • Nitroxolinum
  • Nicene
  • Nitroxolin
  • Noxibiol
  • Nibiol
  • Noxin
  • 8-Quinolinol, 5-nitro-
  • 5-Nitroxine
  • 5-Nitroks
  • 5-Nitro-8-oxychinoline
  • BAS 58
  • Galinok
  • Isinok
  • Nicene Forte
  • Nitroxoline (INN)
  • Uro-Coli
  • Nitroxlina
  • Nitroxoline (TN)
Show all 32 synonyms
  • HNQ
  • Nitroxoline (Standard)
  • 3ai8
  • 5-Nitro-quinolin-8-ol
  • 5-Nitro-8hydroxyquinoline
  • Quinolin-8-ol, 5-nitro-
  • 8-Hydroxy-5-nitro-chinoline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
190.16 g/molcalc.
Exact mass
190.0378 Dacalc.
LogP (octanol/water)
1.85calc.
Topological polar surface area
76.26 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
14calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2ncccc2c1

c1ccc2ncccc2c1

2 rings, 10 atoms, the Quinoline ring system.

21,766 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H301Toxic if swallowed.
  • H302Harmful if swallowed.
  • H311Toxic in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H331Toxic if inhaled.
  • H335May cause respiratory irritation.
Precautionary statements (23)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P316Get emergency medical help immediately.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nitroxoline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 31 suppliers
30 of 30 offers

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Where suppliers are based

31 suppliers in 9 countries

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Nitroxoline price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Infective Agents, Urinary
  • Antifungal Agents

Roles

  • antibacterial agent
  • antifungal agent
  • antiinfective agent
  • antimicrobial agent
  • pharmaceutical
  • renal agent

Pharmacology

Nitroxoline is an orally bioavailable quinoline antibiotic, with potential antineoplastic activity. Upon oral administration, nitroxoline may induce apoptosis and inhibit tumor cell proliferation in NF1-null Schwann cells in neurofibromatosis type I through as of yet undisclosed mechanism of actions, other than inhibiting the RAS/mitogen-activated protein kinase (MAPK) pathway, and possibly through modulating mitochondrial function. NF1 encodes neurofibromin which inactivates Ras. Loss of neurofibromin in neurofibromatosis type I results in increased Ras activity, which promotes the transcription of genes that drives tumor cell growth and proliferation. As an antibiotic, nitroxoline inhibits bacterial RNA polymerase.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Nitroxoline (INN) and its salts, Ref no: 209, Annex ref: II/209

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nitroxoline is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nitroxoline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nitroxoline, based on the data on this page

What is Nitroxoline?

Nitroxoline is a monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5. It has a role as an antimicrobial agent, an antiinfective agent, an antifungal agent and a renal agent. It is a C-nitro compound and a monohydroxyquinoline.

What is the CAS number of Nitroxoline?

The CAS registry number of Nitroxoline is 4008-48-4.

What is the molecular formula and weight of Nitroxoline?

The molecular formula of Nitroxoline is C9H6N2O3 and its molar mass is 190.16 g/mol.

What is Nitroxoline used for?

Known uses and roles of Nitroxoline include building blocks in research and laboratory, screening compounds in research and laboratory, antibacterial agent, antifungal agent, antiinfective agent and 5 more.

Is Nitroxoline hazardous?

Nitroxoline carries the GHS signal word "Danger". Main hazards: toxic if swallowed, harmful if swallowed, toxic in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nitroxoline?

Nitroxoline is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nitroxoline?

CompoundList lists 31 suppliers of Nitroxoline in China, United States, India, Germany and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nitroxoline in India?

6 suppliers in India list Nitroxoline on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nitroxoline?

Suppliers quote Nitroxoline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nitroxoline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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