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Aromatic building blocks

Nylidrin

Also known as Buphenine, Buphenin, Nilidrine

CAS 447-41-6Formula C19H25NO2Molar mass 299.41 g/molEC 207-182-2
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 6 suppliers listed
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Nylidrin chemical structure, C19H25NO2, CAS 447-41-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from methanol
Melting point
111 °C
Solubility
Mol wt 335.88. Crystals. Sparingly sol in water, slightly sol in alcohol. Practically in…
HS code
292250
Category
Aromatic building blocks
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Nylidrin?

Plain description, key identifiers and synonyms

4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol is an alkylbenzene.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol
CAS number
447-41-6 CAS number cross-checked
EC number
207-182-2
Molecular formula
C19H25NO2
UNII
695DKH33EI
MDL number
MFCD00599550
InChIKey
PTGXAUBQBSGPKF-UHFFFAOYSA-N
InChI
InChI=1S/C19H25NO2/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17/h3-7,10-15,19-22H,8-9H2,1-2H3
SMILES (canonical and isomeric)
CC(CCC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O

Synonyms

  • Buphenine
  • Buphenin
  • Nilidrine
  • Suprifen-psb
  • Bufenina
  • Bupheninum
  • Phenyl-sec-butyl norsuprifen
  • 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol
  • p-Hydroxy-N-(1-methyl-3-phenylpropyl)norephedrine
  • Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-
  • 1-(p-Hydroxyphenyl)-2-(1'-methyl-3'-phenylpropylamino)-1-propanol
  • 4-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzenemethanol
  • p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzyl alcohol
  • Benzyl alcohol, p-hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-
  • Bufenine
  • 4-(1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl)phenol
  • 4-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]propyl}phenol
  • Buphenine (INN)
  • 4-(1-Hydroxy-2-((4-phenylbutan-2-yl)amino)propyl)phenol
  • Nylidrinum
  • 4-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]propyl}phenol
  • Benzenemethanol, 4-hydroxy-alpha-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-
  • SKF 1700-A
  • DivK1c_000109
  • Sdccgsbi-0050886.p005

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from methanolexp.
Odour
ODORLESSexp.
Taste
TASTELESSexp.
Melting point
111 °Cexp.
Solubility
Mol wt 335.88. Crystals. Sparingly sol in water, slightly sol in alcohol. Practically insol in ether, chloroform, benzene /Hydrochloride/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
299.41 g/molcalc.
Exact mass
299.1885 Dacalc.
LogP (octanol/water)
3.43calc.
Topological polar surface area
52.49 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
7calc.
Heavy atoms
22calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.37calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCCNCCc2ccccc2)cc1

c1ccc(CCCNCCc2ccccc2)cc1

2 rings, 18 atoms.

117 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H400Very toxic to aquatic life.
Precautionary statements (18)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Nylidrin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers
  • Allchem Lifescience Limited
    India ManufacturerUnclaimed profile
    BuphenineGrade, purity and minimum order on request
    Price on request
    View
  • AChemBlock
    United States, HaywardUnclaimed profile
    NylidrinGrade, purity and minimum order on request
    Price on request
    View
  • AgroIntelBioScan.com
    Singapore, SingaporeUnclaimed profile
    NylidrinGrade, purity and minimum order on request
    Price on request
    View
  • Chemenu. Inc.
    China, ShanghaiUnclaimed profile
    NylidrinGrade, purity and minimum order on request
    Price on request
    View
  • ChemShuttle
    United States, BurlingameUnclaimed profile
    NylidrinGrade, purity and minimum order on request
    Price on request
    View
  • Specs
    Netherlands, ZoetermeerUnclaimed profile
    NylidrinGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 5 countries

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Nylidrin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Mesh Heading: adrenergic beta-Agonists, sympathomimetics, tocolytic Agents, vasodilator Agents.

Veterinary medication:.

/SRP67: Former use:/ MEDICATION.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic beta-Agonists
  • Sympathomimetics
  • Tocolytic Agents
  • Vasodilator Agents

How it is made

By dissolving p-hydroxynorephedrine & benzylacetone in alcohol &... Hydrogenating in presence of raney nickel or...suitable catalyst. .../Carbonyl group is added/ to form aminoalcohol deriv, followed by reduction of... Carbinol group. .../Base/ dissolved in ethanol...& pptd as hydrochloride by...stream of hcl.

French patent 968,273 (1950 to Troponwerke Dinklage), British patents 669,574, 669,575 (1952), Kulz, Schopf, US patents 2,661,372, 2,661,373 (1953).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Nylidrin is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Nylidrin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Nylidrin, based on the data on this page

What is Nylidrin?

4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol is an alkylbenzene.

What is the CAS number of Nylidrin?

The CAS registry number of Nylidrin is 447-41-6.

What is the molecular formula and weight of Nylidrin?

The molecular formula of Nylidrin is C19H25NO2 and its molar mass is 299.41 g/mol.

What is Nylidrin used for?

Mesh Heading: adrenergic beta-Agonists, sympathomimetics, tocolytic Agents, vasodilator Agents. Veterinary medication:. /SRP67: Former use:/ MEDICATION. Use classes: Pharmaceuticals.

Is Nylidrin hazardous?

Nylidrin carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Nylidrin?

Nylidrin is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Nylidrin?

CompoundList lists 6 suppliers of Nylidrin in United States, China, India, Netherlands and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Nylidrin in India?

1 supplier in India list Nylidrin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Nylidrin?

Suppliers quote Nylidrin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Nylidrin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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