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Heterocyclic building blocks

Patulin

Also known as Clavacin, Clavatin, Patuline

CAS 149-29-1Formula C7H6O4Molar mass 154.12 g/molEC 205-735-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant 20 suppliers listed
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Patulin chemical structure, C7H6O4, CAS 149-29-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Compact prisms or thick plates from ether or chloroform
Melting point
111 °C
Solubility
Soluble in water
HS code
293220
Category
Heterocyclic building blocks
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Patulin?

Plain description, key identifiers and synonyms

Patulin is a furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic. It has a role as a mutagen, a mycotoxin, an antimicrobial agent, a carcinogenic agent, an Aspergillus metabolite and a Penicillium metabolite. It is a gamma-lactone, a lactol and a furopyran.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one
CAS number
149-29-1 CAS number cross-checkedOther or deprecated CAS: 247172-18-5, 748133-69-9
EC number
205-735-2
Molecular formula
C7H6O4
UNII
95X2BV4W8R
MDL number
MFCD00005858
InChIKey
ZRWPUFFVAOMMNM-UHFFFAOYSA-N
InChI
InChI=1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
SMILES (canonical and isomeric)
C1C=C2C(=CC(=O)O2)C(O1)O

Synonyms

  • Clavacin
  • Clavatin
  • Patuline
  • Expansine
  • Expansin
  • Claviformin
  • Clairformin
  • Claviform
  • Leucopin
  • Terinin
  • Mycoin C3
  • Gigantin
  • Penicidin
  • Mycoin
  • Tercinin
  • Mycoine C3
  • Mycosin
  • Penatin
  • Mycoin C
  • 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
  • 4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one
  • 4H-Furo[3,2-c]pyran-2(6H)-one, 4-hydroxy-
  • 4-Hydroxy-4H-furo(3,2-C)pyran-2(6H)-one
  • 4H-Furo(3,2-c)pyran-2(6H)-one, 4-hydroxy-
  • 4,6-Dihydro-4-hydroxy-2H-furo(3,2-c)pyran-2-one
Show all 37 synonyms
  • (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid, 3,4-lactone
  • (2,4-Dihydroxy-2H-pyran-3(6H)-ylidene)acetic acid-3,4-lactone
  • Acetic acid, (2,4-dihydroxy-2H-pyran-3(6H)-ylidene)-, 3,4-lactone
  • 4H-Furo(3,3-c)pyran-2(6H)-one, 4-hydroxy-
  • 4-hydroxy-2H,4H,6H-furo[3,2-c]pyran-2-one
  • 2,4-Dihydroxy-2H-pyran-delta-3(6H),alpha-acetic acid-3,4-lactone
  • 2H-Pyran-delta(sup 3(6H),alpha)-acetic acid, 2,4-dihydroxy-, 3,4-lactone
  • 4-hydroxy-2H,4H,6H-furo(3,2-c)pyran-2-one
  • 4-hydroxy-4,6-dihydrofuro(3,2-c)pyran-2-one
  • Flavicin
  • SCH 351633
  • Patulin-13C3

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Compact prisms or thick plates from ether or chloroformexp.
Odour
Odorlessexp.
Melting point
111 °Cexp.
Solubility
Soluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
154.12 g/molcalc.
Exact mass
154.0266 Dacalc.
LogP (octanol/water)
-0.3calc.
Topological polar surface area
55.76 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
0calc.
Heavy atoms
11calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=C2COCC=C2O1

O=C1C=C2COCC=C2O1

2 rings, 10 atoms, the 4H-Furo[3,2-c]pyran-2(6H)-one ring system.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H300Fatal if swallowed.
  • H315Causes skin irritation.
Precautionary statements (11)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Patulin suppliers

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All 20 suppliers
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Where suppliers are based

20 suppliers in 7 countries

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Patulin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Purified patulin (is included) in an analytical reagent kit for use as a standard for mycotoxins.

Medication: Patulin was also used at one time as an antibiotic cream for topical application, but was found to cause dermal irritation. (Former).

Pharmacological actions

  • Mutagens
  • Poisons

Roles

  • Aspergillus metabolite
  • Penicillium metabolite
  • aetiopathogenetic role
  • antimicrobial agent
  • carcinogenic agent
  • eukaryotic metabolite
  • fungal metabolite
  • genotoxin
  • metabolite
  • mutagen
  • mycotoxin
  • poison
  • toxin

How it is made

An antibiotic derived from the metabolism of a number of fungi... Birkinshaw et al Lancet 245, 625 (1943), Birkinshaw, Michael, US Pat 2,417,584 (1947 To Therap Res Corp Of Great Britain)...Norstadt, McCalla, Appl Microbiol 17, 193 (1969).

Patulin is not produced commercially, but it is available from one company in the US for experimental purposes only and is also available in Israel. This chemical is not authorized for use as a drug by the US Food and Drug Administration.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Patulin is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Patulin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Patulin, based on the data on this page

What is Patulin?

Patulin is a furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone.

What is the CAS number of Patulin?

The CAS registry number of Patulin is 149-29-1. Other or deprecated CAS numbers: 247172-18-5, 748133-69-9.

What is the molecular formula and weight of Patulin?

The molecular formula of Patulin is C7H6O4 and its molar mass is 154.12 g/mol.

What is Patulin used for?

Purified patulin (is included) in an analytical reagent kit for use as a standard for mycotoxins. Medication: Patulin was also used at one time as an antibiotic cream for topical application, but was found to cause dermal irritation. (Former).

Is Patulin hazardous?

Patulin carries the GHS signal word "Danger". Main hazards: fatal if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Patulin?

Patulin is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Patulin?

CompoundList lists 20 suppliers of Patulin in China, United States, Germany, United Kingdom and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Patulin?

Suppliers quote Patulin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Patulin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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