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Central nervous system drugs

Promazine

Also known as Promazin, Ampazine, Promazina

CAS 58-40-2Formula C17H20N2SMolar mass 284.43 g/molEC 200-382-0
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 18 suppliers listed
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Promazine chemical structure, C17H20N2S, CAS 58-40-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Oily liq
Boiling point
203 to 210
Solubility
In water, 14.2 mg/l @ 24 °C
HS code
293430
Category
Central nervous system drugs
Illustrative photo, 200 litre blue HDPE drums of liquid in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Promazine?

Plain description, key identifiers and synonyms

Promazine is a phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position. It has a role as a phenothiazine antipsychotic drug, a H1-receptor antagonist, a serotonergic antagonist, a dopaminergic antagonist, a muscarinic antagonist, an antiemetic and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. It is a tertiary amine and a member of phenothiazines.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine
CAS number
58-40-2 CAS number cross-checked
EC number
200-382-0
Molecular formula
C17H20N2S
UNII
O9M39HTM5W
InChIKey
ZGUGWUXLJSTTMA-UHFFFAOYSA-N
InChI
InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
SMILES (canonical and isomeric)
CN(C)CCCN1C2=CC=CC=C2SC3=CC=CC=C31

Synonyms

  • Promazin
  • Ampazine
  • Promazina
  • Promwill
  • Romtiazin
  • Sinophenin
  • Prazin
  • Prazine
  • Neo-Hibernex
  • Protactyl
  • Berophen
  • Esparin
  • Verophen
  • Tomil
  • Promazinum
  • N-(3-Dimethylaminopropyl)phenothiazine
  • N-Dimethylamino-1-methylethyl thiodiphenylamine
  • Combelen
  • RP 3276
  • WY 1094
  • 10-(3-(Dimethylamino)propyl)phenothiazine
  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-
  • dimethyl[3-(10H-phenothiazin-10-yl)propyl]amine
  • 10-[3-(Dimethylamino)propyl]phenothiazine
  • Phenothiazine, 10-(3-(dimethylamino)propyl)-
Show all 35 synonyms
  • Phenothiazine, 10-[3-(dimethylamino)propyl]-
  • N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine
  • dimethyl(3-(10H-phenothiazin-10-yl)propyl)amine
  • propazinum (for the hydrochloride)
  • Liranol
  • Promazine (INN)
  • N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
  • N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine
  • 3276 R. P.
  • Propazinum

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oily liqexp.
Odour
Amine odorexp.
Boiling point
203 to 210exp.
Solubility
In water, 14.2 mg/l @ 24 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
284.43 g/molcalc.
Exact mass
284.1347 Dacalc.
LogP (octanol/water)
4.24calc.
Topological polar surface area
6.48 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Nc1ccccc1S2

c1ccc2c(c1)Nc1ccccc1S2

3 rings, 14 atoms, the Phenothiazine ring system.

1,001 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (14)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Promazine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 18 suppliers
18 of 18 offers
  • 001Chemical
    China, HangzhouUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
    View
  • 10X Chem
    United States, San DiegoUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
    View
  • Angene Chemical
    China, NanjingUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
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  • BLD Pharm
    China, ShanghaiUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
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  • Capot
    China, HangzhouUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
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  • Cooke Chemical Co., Ltd.
    China, FuxinUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
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  • Enamine Ltd
    Ukraine, KyivUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
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  • Hairui Chemical
    China, HangzhouUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
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  • InvivoChem LLC
    China, GuangZhouUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
    View
  • J&H Chemical Co.,ltd
    China, HangzhouUnclaimed profile
    PromazineGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

18 suppliers in 5 countries

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Promazine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antiemetics
  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • H1-receptor antagonist
  • antagonist
  • antiemetic
  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • dopaminergic agent
  • dopaminergic antagonist
  • enzyme inhibitor
  • first generation antipsychotic
  • histamine antagonist
  • histaminergic drug
  • muscarinic antagonist
  • neurotransmitter agent
  • pharmaceutical
  • phenothiazine antipsychotic drug
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

How it is made

Prepd by heating xylene soln of phenothiazine & 3-dimethyl-amino-1-chloropropane in presence of sodamide: Charpentier, US patent 2,519,886 (1950 to Rhone-Poulenc).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Promazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Promazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Promazine, based on the data on this page

What is Promazine?

Promazine is a phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.

What is the CAS number of Promazine?

The CAS registry number of Promazine is 58-40-2.

What is the molecular formula and weight of Promazine?

The molecular formula of Promazine is C17H20N2S and its molar mass is 284.43 g/mol.

What is Promazine used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is Promazine hazardous?

Promazine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause an allergic skin reaction, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Promazine?

Promazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Promazine?

CompoundList lists 18 suppliers of Promazine in China, United States, Czech Republic, Netherlands and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Promazine?

Suppliers quote Promazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Promazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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