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Respiratory, allergy and digestive drugs

Promethazine

Also known as Proazamine, Diphergan, Protazine

CAS 60-87-7Formula C17H20N2SMolar mass 284.43 g/molEC 200-489-2
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant, Hazardous to the environment 57 suppliers listed Drug substance
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Promethazine chemical structure, C17H20N2S, CAS 60-87-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
60 °C
Boiling point
190 to 192
Solubility
In water, 1.56 × 10⁻² g/L (15.6 mg/L) at 24 °C
HS code
293430
Category
Respiratory, allergy and digestive drugs
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Promethazine?

Plain description, key identifiers and synonyms

Promethazine is a tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety. It has a role as an anticoronaviral agent, a sedative, a local anaesthetic, a H1-receptor antagonist, an anti-allergic agent, an antiemetic and an antipruritic drug. It is a tertiary amine and a member of phenothiazines. It is a conjugate base of a promethazine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
CAS number
60-87-7 CAS number cross-checkedOther or deprecated CAS: 38878-40-9
EC number
200-489-2
Molecular formula
C17H20N2S
UNII
FF28EJQ494
InChIKey
PWWVAXIEGOYWEE-UHFFFAOYSA-N
InChI
InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
SMILES (canonical and isomeric)
CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C

Synonyms

  • Proazamine
  • Diphergan
  • Protazine
  • Vallergine
  • Dimapp
  • Promethazin
  • Fargan
  • Procit
  • Promazinamide
  • Promezathine
  • Prometazin
  • Prothazin
  • Hiberna
  • Histargan
  • Phenargan
  • Phensedyl
  • Fenazil
  • Provigan
  • Tanidil
  • Thiergan
  • Prometazina
  • Fenetazine
  • Promethazinum
  • Promethiazine
  • Prometh
Show all 39 synonyms
  • Lilly 01516
  • N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine
  • SKF 1498
  • (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
  • WY 509
  • RP 3277
  • 10-(2-Dimethylaminopropyl)phenothiazine
  • 10-[2-(Dimethylamino)propyl]phenothiazine
  • N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine
  • N-Dimethylamino-2-methylethyl thiodiphenylamine
  • 10-(2-(Dimethylamino)-2-methylethyl)phenothiazine
  • Phenothiazine, 10-(2-dimethylaminopropyl)-
  • 10-(2-(Dimethylamino)propyl)phenothiazine
  • 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
60 °Cexp.
Boiling point
190 to 192exp.
Solubility
In water, 1.56 × 10⁻² g/L (15.6 mg/L) at 24 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
284.43 g/molcalc.
Exact mass
284.1347 Dacalc.
LogP (octanol/water)
4.24calc.
Topological polar surface area
6.48 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.29calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Nc1ccccc1S2

c1ccc2c(c1)Nc1ccccc1S2

3 rings, 14 atoms, the Phenothiazine ring system.

1,001 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H318Causes serious eye damage.
  • H319Causes serious eye irritation.
  • H410Very toxic to aquatic life with long lasting effects.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Promethazine suppliers

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All 57 suppliers
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Where suppliers are based

57 suppliers in 15 countries

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Promethazine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

An antiallergic, in pruritus, for motion sickness and sedation, and also in animals.

Widely used as a hypnotic agent.

Therapeutic category: Antihistaminic.

Therapeutic category (veterinary): Antihistaminic, antiemetic, CNS depressant.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Allergic Agents
  • Antipruritics
  • Histamine H1 Antagonists

Roles

  • H1-receptor antagonist
  • anaesthetic
  • analgesic
  • antagonist
  • anti-allergic agent
  • anticoronaviral agent
  • antidepressant
  • antiemetic
  • antimicrobial agent
  • antipruritic drug
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dermatologic drug
  • gastrointestinal drug
  • histamine antagonist
  • histaminergic drug
  • local anaesthetic
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • sedative
  • tranquilizing drug

Pharmacology

Promethazine is a Phenothiazine.

How it is made

Promethazine is synthesized from 10-phenothiazine-2-propyl chloride and dimethylamine in the presence of Cu.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Promethazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Promethazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Promethazine, based on the data on this page

What is Promethazine?

Promethazine is a tertiary amine that is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropan-2-amine moiety.

What is the CAS number of Promethazine?

The CAS registry number of Promethazine is 60-87-7. Other or deprecated CAS numbers: 38878-40-9.

What is the molecular formula and weight of Promethazine?

The molecular formula of Promethazine is C17H20N2S and its molar mass is 284.43 g/mol.

What is Promethazine used for?

An antiallergic, in pruritus, for motion sickness and sedation, and also in animals. Widely used as a hypnotic agent. Therapeutic category: Antihistaminic. Therapeutic category (veterinary): Antihistaminic, antiemetic, CNS depressant. Use classes: Pharmaceuticals.

Is Promethazine hazardous?

Promethazine carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Promethazine?

Promethazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Promethazine?

CompoundList lists 57 suppliers of Promethazine in United States, China, India, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Promethazine in India?

6 suppliers in India list Promethazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Promethazine?

Suppliers quote Promethazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Promethazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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