CompoundList
Sign in
Insecticides and acaricides

Prothoate

Also known as Fostion, Prothoat, Trimethoate

CAS 2275-18-5Formula C9H20NO3PS2Molar mass 285.37 g/molEC 218-893-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe)
Get quotes Safety data
Prothoate chemical structure, C9H20NO3PS2, CAS 2275-18-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless yellow crystals (tech is an amber to yellow semi-solid)
Melting point
28.5 °C
Boiling point
330 °C
Density
1.151 at 32 °C
Solubility
In water, 2.5 × 10⁺³ mg/L at 20 °C
HS code
293090
Category
Insecticides and acaricides
Illustrative photo, colourless crystals beside a jumbo bulk bag in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Prothoate?

Plain description, key identifiers and synonyms

Prothoate is an organic thiophosphate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-diethoxyphosphinothioylsulfanyl-N-propan-2-ylacetamide
CAS number
2275-18-5 CAS number cross-checked
EC number
218-893-2
Molecular formula
C9H20NO3PS2
UNII
4V035A5L4B
InChIKey
QTXHFDHVLBDJIO-UHFFFAOYSA-N
InChI
InChI=1S/C9H20NO3PS2/c1-5-12-14(15,13-6-2)16-7-9(11)10-8(3)4/h8H,5-7H2,1-4H3,(H,10,11)
SMILES (canonical and isomeric)
CCOP(=S)(OCC)SCC(=O)NC(C)C

Synonyms

  • Fostion
  • Prothoat
  • Trimethoate
  • FAC (pesticide)
  • Oleofac
  • Telefos
  • American cyanamid 18682
  • FAC 20
  • FAK 40
  • Isopropyl diethyldithiophosphorylacetamide
  • Fak-40
  • 2-diethoxyphosphinothioylsulfanyl-N-propan-2-ylacetamide
  • ENT 24,652
  • 2-Diethoxyphosphinothioylthio-N-isopropylacetamide
  • AC 18682
  • EI 18682
  • O,O-Diethyl S-(N-isopropylcarbamoylmethyl) phosphorodithioate
  • O,O-Diethyl S-isopropylcarbamoylmethyl phosphorodithioate
  • Phosphorodithioic acid, O,O-diethyl ester, S-ester with N-isopropyl-2-mercaptoacetamide
  • O,O-Diethyl S-(N-isopropylcarbamoylmethyl) dithiophosphate
  • O,O-Diethyldithiophosphorylacetic acid, N-monoisopropylamide
  • N-Monoisopropylamide of O,O-diethyldithiophosphorylacetic acid
  • Acetamide, N-isopropyl-2-mercapto-, S-ester with O,O-diethyl phosphorodithioate
  • Phosphorodithioic acid, O,O-diethyl S-(2-((1-methylethyl)amino)-2-oxoethyl) ester
  • O,O-Diethyl S-(2-((1-methylethyl)amino)-2-oxoethyl) phosphorodithioate
Show all 36 synonyms
  • Protoat (Hungarian)
  • Phosphorodithioic acid, O,O-diethyl S-[2-[(1-methylethyl)amino]-2-oxoethyl] ester
  • Protoat
  • O,O-Diethyl phosphorodithioate S-ester with N-2-isopropyl-2-mercaptoacetamide
  • American Cyanamid 18,682
  • American cyanamid-18,682
  • Prothoate 10 microg/mL in Methanol
  • Prothoate 10 microg/mL in Isooctane
  • O,O-Diethyl phosphorodithioate S-ester with N-isopropyl-2-mercaptoacetamide
  • Prothoate 100 microg/mL in Isooctane
  • O,O-Diethyl S-[2-(isopropylamino)-2-oxoethyl] dithiophosphate #

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless yellow crystals (tech is an amber to yellow semi-solid)exp.
Odour
Camphor-like odorexp.
Melting point
28.5 °Cexp.
Boiling point
330 °Cexp.
Density
1.151 at 32 °Cexp.
Solubility
In water, 2.5 × 10⁺³ mg/L at 20 °Cexp.
Vapour pressure
9.75 × 10⁻⁵ mm Hg at 40 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
285.37 g/molcalc.
Exact mass
285.0622 Dacalc.
LogP (octanol/water)
2.54calc.
Topological polar surface area
47.56 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
8calc.
Heavy atoms
16calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.89calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (13)
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P316Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Prothoate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

No supplier listings yet

Post one free request and suppliers who make or trade Prothoate can send you quotes. Your contact details stay private until you accept a quote.

Request quotesSell this chemical

Prothoate price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Systemic acaricide and insecticide (former).

How it is made

By interaction of sodium O,O-diethyl phosphorodithioate with 2-chloro-n-isopropylacetamide or by treating...the reaction product of sodium O,O-diethyl phosphorodithioate & phenyl chloroacetate (with isopropylamine). US PATENT 2494283 (AMERICAN CYANAMID CO), BRITISH PATENT 791824 (MONTEDISON SPA).

Chloroacetic acid + isopropylamine + O,O-diethyldithiophosphoric acid (amide formation/dehydrochlorination)

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 015-032-00-0

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Prothoate is traded under.

HS 2930.90Indicative HS code

Organo-sulphur compounds, other

World exports in 2024
$5.83B
+0.1% vs 2023, imports $5.93B
2019 to 2024
Top exporters
  1. China40.7%
  2. United States10.9%
  3. Japan9.3%
Top importers
  1. United States13.3%
  2. Brazil12.6%
  3. China6.6%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Prothoate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Prothoate, based on the data on this page

What is Prothoate?

Prothoate is an organic thiophosphate.

What is the CAS number of Prothoate?

The CAS registry number of Prothoate is 2275-18-5.

What is the molecular formula and weight of Prothoate?

The molecular formula of Prothoate is C9H20NO3PS2 and its molar mass is 285.37 g/mol.

What is Prothoate used for?

Systemic acaricide and insecticide (former).

Is Prothoate hazardous?

Prothoate carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, harmful to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Prothoate?

Prothoate is usually classified under HS code 293090 (Organo-sulphur compounds, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Prothoate?

Post a free request on CompoundList and suppliers of Prothoate will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Prothoate?

Suppliers quote Prothoate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Prothoate

Get quotes for Prothoate

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Prothoate
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Prothoate with a 3D view, its CAS number and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/prothoate-2275-18-5" title="Prothoate structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Insecticides and acaricides or HS code 293090

Price on request
Free quotes, contact stays private
Get quotes