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Synthesis reagents

Rebastinib

Also known as DCC 2036, DCC-2036 FREE BASE, 4-[4-({[3-Tert-Butyl-1-(Quinolin-6-Yl)-1h-Pyrazol-5-Yl]carbamoyl}amino)-3-Fluorophenoxy]-N-Methylpyridine-2-Carboxamide

CAS 1020172-07-9Formula C30H28FN7O3Molar mass 553.60 g/mol
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Rebastinib chemical structure, C30H28FN7O3, CAS 1020172-07-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1020172-07-9
Formula
C30H28FN7O3
Molar mass
553.60 g/mol
HS code
293349
Category
Synthesis reagents

What is Rebastinib?

Plain description, key identifiers and synonyms

DCC-2036 is a member of the class of ureas that is urea in which one of the nitrogens bears a 3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl substituent, while the other bears a 2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl substituent. It has a role as a tyrosine kinase inhibitor. It is a member of phenylureas, a pyridinecarboxamide, a member of pyrazoles, a member of quinolines and an organofluorine compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[4-[(3-tert-butyl-1-quinolin-6-ylpyrazol-5-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
CAS number
1020172-07-9 CAS number cross-checked
Molecular formula
C30H28FN7O3
UNII
75017Q6I97
MDL number
MFCD19443646
InChIKey
WVXNSAVVKYZVOE-UHFFFAOYSA-N
InChI
InChI=1S/C30H28FN7O3/c1-30(2,3)26-17-27(38(37-26)19-7-9-23-18(14-19)6-5-12-33-23)36-29(40)35-24-10-8-20(15-22(24)31)41-21-11-13-34-25(16-21)28(39)32-4/h5-17H,1-4H3,(H,32,39)(H2,35,36,40)
SMILES (canonical and isomeric)
CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5

Synonyms

  • DCC 2036
  • DCC-2036 FREE BASE
  • 4-[4-({[3-Tert-Butyl-1-(Quinolin-6-Yl)-1h-Pyrazol-5-Yl]carbamoyl}amino)-3-Fluorophenoxy]-N-Methylpyridine-2-Carboxamide
  • 4-(3-fluoro-4-(((3-(2-methyl-2-propanyl)-1-(6-quinolinyl)-1H-pyrazol-5-yl)carbamoyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
  • rebastinibum
  • 4-(4-(((3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)carbamoyl)amino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
  • DCC-2036 (Rebastinib)
  • 4-(4-(3-(3-(tert-butyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
  • N-[3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-N'-[2-fluoro-4-[(2-(methylcarbamoyl)pyridin-4-yl)oxy]phenyl]urea
  • DP 1919
  • 2-Pyridinecarboxamide, 4-[4-[[[[3-(1,1-dimethylethyl)-1-(6-quinolinyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
  • 4-[4-[(5-tert-butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • Rebastinib (USAN)
  • 1-[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]-3-{2-fluoro-4-[2-(methylcarbamoyl)pyridin-4-yloxy]phenyl}urea
  • 3qri
  • 3qrj
  • 2-Pyridinecarboxamide, 4-(4-((((3-(1,1-dimethylethyl)-1-(6-quinolinyl)-1H-pyrazol-5-yl)amino)carbonyl)amino)-3-fluorophenoxy)-N-methyl-
  • DCC-2036, DP 1919, 4-[4-[(5-tert-Butyl-2-quinolin-6-ylpyrazol-3-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • DCC-2036, Rebastinib
  • Rebastinib(DCC-2036)
  • Rebastinib (DCC-2036)
  • DCC-2036 (Rebastinib)?
  • Sdccgsbi-0654390.p001
  • 4-(4-(3-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
  • 4-(4-(((3-tert-Butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)carbamoyl(amino)-3-fluorophenoxy)-N-methylpyridin-2-carboxamide
Show all 29 synonyms
  • 4-[4-[(3-tert-butyl-1-quinolin-6-ylpyrazol-5-yl)carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
  • 4-[4-[[5-tert-butyl-2-(6-quinolyl)pyrazol-3-yl]carbamoylamino]-3-fluoro-phenoxy]-N-methyl-pyridine-2-carboxamide
  • 4-[4-[3-[3-(tert-Butyl)-1-(6-quinolyl)-5-pyrazolyl]ureido]-3-fluorophenoxy]-N-methylpicolinamide
  • N-(3-(1,1-Dimethylethyl)-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-N'-(2-fluoro-4-((2- (methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
553.60 g/molcalc.
Exact mass
553.2238 Dacalc.
LogP (octanol/water)
6.05calc.
Topological polar surface area
123.1 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
6calc.
Heavy atoms
41calc.
Rings
5calc.
Aromatic rings
5calc.
Fraction sp3 carbons
0.17calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccc(Oc2ccncc2)cc1)Nc1ccnn1-c1ccc2ncccc2c1

O=C(Nc1ccc(Oc2ccncc2)cc1)Nc1ccnn1-c1ccc2ncccc2c1

5 rings, 32 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Rebastinib suppliers

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All 6 suppliers
6 of 6 offers

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Where suppliers are based

6 suppliers in 2 countries

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Rebastinib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Protein Kinase Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical
  • protein kinase inhibitor
  • tyrosine kinase inhibitor

Pharmacology

Rebastinib is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Upon oral administration, rebastinib binds to and inhibits the Bcr-Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation, in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine kinases TIE-2 and VEGFR-2. Rebastinib may exhibit more potent activity against T315I Bcr-Abl gatekeeper mutant kinases than other Bcr-Abl kinase inhibitors.

Read more

The TIE-2 and VEGFR-2 receptor tyrosine kinases regulate angiogenesis, respectively, while the Src family kinases Abl, LYN, and HCK Src regulate a variety of cellular responses including differentiation, division, adhesion, and the stress response.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Rebastinib is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Rebastinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Rebastinib, based on the data on this page

What is Rebastinib?

DCC-2036 is a member of the class of ureas that is urea in which one of the nitrogens bears a 3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl substituent, while the other bears a 2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl substituent. It has a role as a tyrosine kinase inhibitor.

What is the CAS number of Rebastinib?

The CAS registry number of Rebastinib is 1020172-07-9.

What is the molecular formula and weight of Rebastinib?

The molecular formula of Rebastinib is C30H28FN7O3 and its molar mass is 553.60 g/mol.

What is Rebastinib used for?

Known uses and roles of Rebastinib include synthesis reagents in research and laboratory, biochemical and pharmacological tools in research and laboratory, antineoplastic agent, enzyme inhibitor, pharmaceutical and 4 more.

Is Rebastinib hazardous?

No GHS hazard classification for Rebastinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Rebastinib?

Rebastinib is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Rebastinib?

CompoundList lists 6 suppliers of Rebastinib in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Rebastinib?

Suppliers quote Rebastinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Rebastinib

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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