CompoundList
Sign in
Screening compounds

Ruserontinib

Also known as SKLB-1028, 9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine, Sklb1028

CAS 1350544-93-2Formula C24H29N9Molar mass 443.56 g/mol
Get quotes Safety data
Ruserontinib chemical structure, C24H29N9, CAS 1350544-93-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1350544-93-2
Formula
C24H29N9
Molar mass
443.56 g/mol
HS code
293359
Category
Screening compounds

What is Ruserontinib?

Plain description, key identifiers and synonyms

Ruserontinib is an orally available inhibitor of epidermal growth factor receptor (EGFR), FMS-related tyrosine kinase 3 (FLT3, STK1, CD135 or FLK2), and the non-receptor tyrosine kinase ABL (Abl), with potential antineoplastic activity. Upon administration, ruserontinib specifically binds to and inhibits EGFR, FLT3 and Abl, which interferes with the activation of EGFR-, FLT3- and Abl-mediated signal transduction pathways and reduces cell proliferation in cancer cells that overexpress EGFR, FLT3 and/or Abl. EGFR, EGFR and Abl are all overexpressed in a variety of cancers and play key roles in tumor cell proliferation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-N-[4-(4-methylpiperazin-1-yl)phenyl]-9-propan-2-yl-8-N-pyridin-3-ylpurine-2,8-diamine
CAS number
1350544-93-2
Molecular formula
C24H29N9
UNII
AQ3TTU8UM7
MDL number
MFCD30471083
InChIKey
WSOHOUHPUOAXIN-UHFFFAOYSA-N
InChI
InChI=1S/C24H29N9/c1-17(2)33-22-21(29-24(33)28-19-5-4-10-25-15-19)16-26-23(30-22)27-18-6-8-20(9-7-18)32-13-11-31(3)12-14-32/h4-10,15-17H,11-14H2,1-3H3,(H,28,29)(H,26,27,30)
SMILES (canonical and isomeric)
CC(C)N1C2=NC(=NC=C2N=C1NC3=CN=CC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C

Synonyms

  • SKLB-1028
  • 9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine
  • Sklb1028
  • SKLB 1028
  • 2-N-[4-(4-methylpiperazin-1-yl)phenyl]-9-propan-2-yl-8-N-pyridin-3-ylpurine-2,8-diamine
  • 9H-Purine-2,8-diamine, 9-(1-methylethyl)-N2-(4-(4-methyl-1-piperazinyl)phenyl)-N8-3-pyridinyl-
  • 2-N-(4-(4-methylpiperazin-1-yl)phenyl)-9-propan-2-yl-8-N-pyridin-3-ylpurine-2,8-diamine
  • 9H-Purine-2,8-diamine, 9-(1-methylethyl)-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-3-pyridinyl-
  • Multikinase Inhibitor SKLB1028
  • EGFR/FLT3/Abl Inhibitor SKLB1028
  • N2-[4-(4-methylpiperazin-1-yl)phenyl]-9-(propan-2-yl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine
  • SKLB-?1028
  • 9-(1-Methylethyl)-N2-(4-(4-methyl-1-piperazinyl)phenyl)-N8-3-pyridinyl-9H-purine-2,8-diamine
  • 9-(1-Methylethyl)-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-3-pyridinyl-9H-purine-2,8-diamine
  • N2-(4-(4-Methylpiperazin-1-yl)phenyl)-9-(propan-2-yl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine
  • US9096601, 8-29
  • 9-isopropyl-N2-[4-(4-methylpiperazin-1-yl)phenyl]-N8-(3-pyridyl)purine-2,8-diamine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
443.56 g/molcalc.
Exact mass
443.2546 Dacalc.
LogP (octanol/water)
4.04calc.
Topological polar surface area
87.03 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
6calc.
Heavy atoms
33calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cncc(Nc2nc3cnc(Nc4ccc(N5CCNCC5)cc4)nc3[nH]2)c1

c1cncc(Nc2nc3cnc(Nc4ccc(N5CCNCC5)cc4)nc3[nH]2)c1

5 rings, 29 atoms.

No other chemical in our database has this scaffold.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Ruserontinib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

No supplier listings yet

Post one free request and suppliers who make or trade Ruserontinib can send you quotes. Your contact details stay private until you accept a quote.

Request quotesSell this chemical

Ruserontinib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ruserontinib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ruserontinib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ruserontinib, based on the data on this page

What is Ruserontinib?

Ruserontinib is an orally available inhibitor of epidermal growth factor receptor (EGFR), FMS-related tyrosine kinase 3 (FLT3, STK1, CD135 or FLK2), and the non-receptor tyrosine kinase ABL (Abl), with potential antineoplastic activity.

What is the CAS number of Ruserontinib?

The CAS registry number of Ruserontinib is 1350544-93-2.

What is the molecular formula and weight of Ruserontinib?

The molecular formula of Ruserontinib is C24H29N9 and its molar mass is 443.56 g/mol.

What is Ruserontinib used for?

Known uses and roles of Ruserontinib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Ruserontinib hazardous?

No GHS hazard classification for Ruserontinib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Ruserontinib?

Ruserontinib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ruserontinib?

Post a free request on CompoundList and suppliers of Ruserontinib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Ruserontinib?

Suppliers quote Ruserontinib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ruserontinib

Get quotes for Ruserontinib

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Ruserontinib
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Ruserontinib with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/ruserontinib-1350544-93-2" title="Ruserontinib structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Screening compounds or HS code 293359

Price on request
Free quotes, contact stays private
Get quotes