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Cardiovascular and metabolic drugs

Sumatriptan

Also known as Imitrex, Sumatran, Sumax

CAS 103628-46-2Formula C14H21N3O2SMolar mass 295.41 g/molEC 600-462-9
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 92 suppliers listed Drug substance
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Sumatriptan chemical structure, C14H21N3O2S, CAS 103628-46-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
103628-46-2
Formula
C14H21N3O2S
Molar mass
295.41 g/mol
Melting point
169 to 171
HS code
293590
Category
Cardiovascular and metabolic drugs

What is Sumatriptan?

Plain description, key identifiers and synonyms

Sumatriptan is a sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults. It has a role as a serotonergic agonist and a vasoconstrictor agent. It is a member of tryptamines and a sulfonamide. It is functionally related to a N,N-dimethyltryptamine. It is a conjugate base of a sumatriptan(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide
CAS number
103628-46-2 CAS number cross-checked
EC number
600-462-9
Molecular formula
C14H21N3O2S
UNII
8R78F6L9VO
MDL number
MFCD00866222
InChIKey
KQKPFRSPSRPDEB-UHFFFAOYSA-N
InChI
InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
SMILES (canonical and isomeric)
CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C

Synonyms

  • Imitrex
  • Sumatran
  • Sumax
  • Imigran
  • Sumatriptanum
  • Imigran Recovery
  • 1-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide
  • 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide
  • 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide
  • 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide
  • Tosymra
  • 3-[2-(Dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide
  • 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methylmethanesulfonamide
  • 1H-Indole-5-methanesulfonamide, 3-[2-(dimethylamino)ethyl]-N-methyl-
  • 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide
  • Dfn-11 (sumatriptan injection)
  • 1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide
  • (3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide
  • 1H-Indole-5-methanesulfonamide, 3-(2-(dimethylamino)ethyl)-N-methyl-
  • 3-(2-(Dimethylamino)ethyl)-N-methylindole-5-methanesulfonamide
  • Imigran Radis
  • (3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide
  • {3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide
  • 1-(3-(2-dimethylaminoethyl)-1H-indol-5-yl)-N-methyl-methanesulfonamide
  • 1-(3-(2-dimethylaminoethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide
Show all 34 synonyms
  • Succinate, Sumatriptan
  • AVP 825
  • Imitrex (TN)
  • GR 43175
  • GR 43175X
  • Imigran (TN)
  • Sumatriptan (JAN/USP/INN)
  • Tosymra (nasal spray)
  • Sumatriptan Impurity 16

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Melting point
169 to 171exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
295.41 g/molcalc.
Exact mass
295.1354 Dacalc.
LogP (octanol/water)
1.32calc.
Topological polar surface area
65.2 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2[nH]ccc2c1

c1ccc2[nH]ccc2c1

2 rings, 9 atoms, the Indole ring system.

25,097 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H319Causes serious eye irritation.
  • H361Suspected of damaging fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (9)
  • P203Obtain, read and follow all safety instructions before use.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P337 + P317If eye irritation persists: Get medical help.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Sumatriptan suppliers

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All 92 suppliers
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Where suppliers are based

92 suppliers in 21 countries

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Sumatriptan price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Antimigraine.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Serotonin 5-HT1 Receptor Agonists
  • Vasoconstrictor Agents

Roles

  • analgesic
  • anti-obesity agent
  • cardiovascular drug
  • neurotransmitter agent
  • pharmaceutical
  • serotonergic agonist
  • serotonergic drug
  • vasoconstrictor agent

Pharmacology

Sumatriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist. The mechanism of action of sumatriptan is as a Serotonin 1b Receptor Agonist and Serotonin 1d Receptor Agonist.

How it is made

Preparation: M. D. Dowle, I. H. Coates, DE 3320521, eidem, US 4816470, A. W. Oxford, GB 2162522 (1983, 1989, 1986 all to Glaxo).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Sumatriptan is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Sumatriptan is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Sumatriptan, based on the data on this page

What is Sumatriptan?

Sumatriptan is a sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family).

What is the CAS number of Sumatriptan?

The CAS registry number of Sumatriptan is 103628-46-2.

What is the molecular formula and weight of Sumatriptan?

The molecular formula of Sumatriptan is C14H21N3O2S and its molar mass is 295.41 g/mol.

What is Sumatriptan used for?

Therapeutic category: Antimigraine. Use classes: Pharmaceuticals.

Is Sumatriptan hazardous?

Sumatriptan carries the GHS signal word "Warning". Main hazards: causes serious eye irritation, suspected of damaging fertility or the unborn child, suspected of damaging the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Sumatriptan?

Sumatriptan is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Sumatriptan?

CompoundList lists 92 suppliers of Sumatriptan in United States, China, India, Spain and 17 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Sumatriptan in India?

13 suppliers in India list Sumatriptan on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Sumatriptan?

Suppliers quote Sumatriptan on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Sumatriptan

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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