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Aromatic building blocks

Tacedinaline

Also known as ci-994, 4-acetamido-N-(2-aminophenyl)benzamide, CI 994

CAS 112522-64-2Formula C15H15N3O2Molar mass 269.30 g/molEC 631-226-3
GHS signal word: Warning. Pictograms: Harmful or irritant 18 suppliers listed
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Tacedinaline chemical structure, C15H15N3O2, CAS 112522-64-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
112522-64-2
Formula
C15H15N3O2
Molar mass
269.30 g/mol
EC number
631-226-3
HS code
292429
Category
Aromatic building blocks

What is Tacedinaline?

Plain description, key identifiers and synonyms

Tacedinaline is a benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers. It has a role as an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of acetamides, a member of benzamides and a substituted aniline. It is functionally related to a 1,2-phenylenediamine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-acetamido-N-(2-aminophenyl)benzamide
CAS number
112522-64-2 CAS number cross-checkedOther or deprecated CAS: 58338-59-3
EC number
631-226-3
Molecular formula
C15H15N3O2
UNII
UMF554N5FG
MDL number
MFCD00866266
InChIKey
VAZAPHZUAVEOMC-UHFFFAOYSA-N
InChI
InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
SMILES (canonical and isomeric)
CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

Synonyms

  • ci-994
  • 4-acetamido-N-(2-aminophenyl)benzamide
  • CI 994
  • Tacedinalina
  • 4-(Acetylamino)-N-(2-aminophenyl)benzamide
  • N-acetyldinaline
  • Goe 5549
  • Goe-5549
  • PD 123654
  • C.I. 994
  • N-(2-aminophenyl)-4-acetamidobenzamide
  • tacedinalinum
  • N-acetyl Dinaline
  • Acetyldinaline
  • 4-acetylamino-N-(2'-aminophenyl)benzamide
  • CI994 (Tacedinaline)
  • Tacedinaline (CI-994)
  • Tacedinaline (CI994)
  • Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-
  • 4-(Acetylamino)-N-(2-aminophenyl)be nzamide
  • Tacedinaline (USAN/INN)
  • CI-994, Free Base
  • CI994 (Tacedinaline)?
  • CI-994, >=98% (HPLC), powder
  • 4-Acetamino-N-(2'-aminophenyl)-benzamide
Show all 26 synonyms
  • CI994, CI-994, CI 994, PD123654, PD-123654, PD 123654, Tacedinaline, acetyldinaline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
269.30 g/molcalc.
Exact mass
269.1164 Dacalc.
LogP (octanol/water)
2.48calc.
Topological polar surface area
84.22 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.07calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccc1)c1ccccc1

O=C(Nc1ccccc1)c1ccccc1

2 rings, 15 atoms, the Benzanilide ring system.

13,118 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H319Causes serious eye irritation.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P317If eye irritation persists: Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Tacedinaline suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 18 suppliers
18 of 18 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

18 suppliers in 3 countries

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Tacedinaline price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Histone Deacetylase Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Tacedinaline is an orally bioavailable substituted benzamide derivative with potential antineoplastic activity. Tacedinaline inhibits histone deacetylation, which may result in histone hyperacetylation, followed by the induction of differentiation, the inhibition of cell proliferation, and apoptosis in susceptible tumor cell populations.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tacedinaline is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tacedinaline is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tacedinaline, based on the data on this page

What is Tacedinaline?

Tacedinaline is a benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells.

What is the CAS number of Tacedinaline?

The CAS registry number of Tacedinaline is 112522-64-2. Other or deprecated CAS numbers: 58338-59-3.

What is the molecular formula and weight of Tacedinaline?

The molecular formula of Tacedinaline is C15H15N3O2 and its molar mass is 269.30 g/mol.

What is Tacedinaline used for?

Known uses and roles of Tacedinaline include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, enzyme inhibitor, pharmaceutical and 2 more.

Is Tacedinaline hazardous?

Tacedinaline carries the GHS signal word "Warning". Main hazards: causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Tacedinaline?

Tacedinaline is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tacedinaline?

CompoundList lists 18 suppliers of Tacedinaline in China, United States and United Kingdom. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tacedinaline?

Suppliers quote Tacedinaline on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Tacedinaline

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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