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Screening compounds

Thiofentanyl

Also known as Thienylfentanyl, thienylfentanil, N-(1-(beta-(2-Thienyl)ethyl)-4-piperidyl)propioanilide

CAS 1165-22-6Formula C20H26N2OSMolar mass 342.51 g/mol
Prohibited, not for trade
Why it is not for trade
Thiofentanyl chemical structure, C20H26N2OS, CAS 1165-22-6
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1165-22-6
Formula
C20H26N2OS
Molar mass
342.51 g/mol
HS code
293499
Category
Screening compounds

What is Thiofentanyl?

Plain description, key identifiers and synonyms

Thienylfentanyl is an anilide resulting from the formal condensation of the aryl amino group of N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It is an anilide, a member of piperidines, a member of thiophenes and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-phenyl-N-[1-(2-thiophen-2-ylethyl)piperidin-4-yl]propanamide
CAS number
1165-22-6 CAS number cross-checked
Molecular formula
C20H26N2OS
UNII
954535Y32Y
InChIKey
YMRFZDHYDKZXPA-UHFFFAOYSA-N
InChI
InChI=1S/C20H26N2OS/c1-2-20(23)22(17-7-4-3-5-8-17)18-10-13-21(14-11-18)15-12-19-9-6-16-24-19/h3-9,16,18H,2,10-15H2,1H3
SMILES (canonical and isomeric)
CCC(=O)N(C1CCN(CC1)CCC2=CC=CS2)C3=CC=CC=C3

Synonyms

  • Thienylfentanyl
  • thienylfentanil
  • N-(1-(beta-(2-Thienyl)ethyl)-4-piperidyl)propioanilide
  • N-Phenyl-N-(1-((2-thienyl)ethyl)-4-piperidinyl)propanamide
  • Propionanilide, N-(1-(2-(2-thienyl)ethyl)-4-piperidyl)-
  • IDS-NT-005(SECT.3)
  • 5-22-08-00089 (Beilstein Handbook Reference)
  • N-phenyl-N-{1-[2-(2-thienyl)ethyl]piperidin-4-yl}propanamide
  • N-(1-(2-(Thienyl)ethyl)-4-piperidyl)propionanilide
  • N-Phenyl-N-(1-(2-(2-thienyl)ethyl)piperidin-4-yl)propanamide
  • Propanamide, N-phenyl-N-(1-(2-(2-thienyl)ethyl)-4-piperidinyl)-
  • N-Phenyl-N-(1-(2-(2-thienyl)ethyl)-4-piperidinyl)propanamide
  • N-phenyl-N-[1-[2-(2-thienyl)ethyl]-4-piperidinyl]propanamide
  • DEA No. 9835
  • N-Phenyl-N-{1-[2-(thiophen-2-yl)ethyl]piperidin-4-yl}propanamide
  • N-{1-[2-(2-Thienyl)ethyl]-4-piperidyl}propionanilide
  • N-phenyl-N-[1-[2-(2-thienyl)ethyl]-4-piperidyl]propanamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
342.51 g/molcalc.
Exact mass
342.1766 Dacalc.
LogP (octanol/water)
4.2calc.
Topological polar surface area
23.55 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.45calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(NC2CCN(CCc3cccs3)CC2)cc1

c1ccc(NC2CCN(CCc3cccs3)CC2)cc1

3 rings, 20 atoms.

35 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Thiofentanyl suppliers

Trading restrictions apply to this substance

Narcotic drug

Thiofentanyl is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Thiofentanyl price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Roles

  • agonist
  • analgesic
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Thiofentanyl is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled narcotic drug

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thiofentanyl is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Thiofentanyl is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thiofentanyl, based on the data on this page

What is Thiofentanyl?

Thienylfentanyl is an anilide resulting from the formal condensation of the aryl amino group of N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid. It has a role as an opioid analgesic and a mu-opioid receptor agonist.

What is the CAS number of Thiofentanyl?

The CAS registry number of Thiofentanyl is 1165-22-6.

What is the molecular formula and weight of Thiofentanyl?

The molecular formula of Thiofentanyl is C20H26N2OS and its molar mass is 342.51 g/mol.

What is Thiofentanyl used for?

Known uses and roles of Thiofentanyl include building blocks in research and laboratory, screening compounds in research and laboratory, agonist, analgesic, mu-opioid agent and 6 more.

Is Thiofentanyl hazardous?

No GHS hazard classification for Thiofentanyl is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Thiofentanyl?

Thiofentanyl is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Thiofentanyl on CompoundList?

No. Thiofentanyl is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Thiofentanyl

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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