CompoundList
Sign in
Central nervous system drugs

Thioridazine

Also known as Mellaril, Thioridazin, Mellerette

CAS 50-52-2Formula C21H26N2S2Molar mass 370.59 g/molEC 200-044-2
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 60 suppliers listed Drug substance
Get quotes Compare 60 suppliers
Thioridazine chemical structure, C21H26N2S2, CAS 50-52-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from acetone
Melting point
72 to 74
Boiling point
230 °C
Solubility
Soluble in alcohol (1 in 6), chloroform (1 in 0.81), ether (1 in 3), freely soluble in d…
HS code
293430
Category
Central nervous system drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Thioridazine?

Plain description, key identifiers and synonyms

Thioridazine is a phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position. It has a role as an alpha-adrenergic antagonist, a H1-receptor antagonist, a serotonergic antagonist, a dopaminergic antagonist, a first generation antipsychotic, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor. It is a member of piperidines and a member of phenothiazines. It contains a methylsulfanyl group.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine
CAS number
50-52-2 CAS number cross-checkedOther or deprecated CAS: 107388-89-6
EC number
200-044-2
Molecular formula
C21H26N2S2
UNII
N3D6TG58NI
InChIKey
KLBQZWRITKRQQV-UHFFFAOYSA-N
InChI
InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
SMILES (canonical and isomeric)
CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC

Synonyms

  • Mellaril
  • Thioridazin
  • Mellerette
  • Sonapax
  • Malloryl
  • Meleril
  • Melleril
  • Mellaril-S
  • Mallorol
  • Mellerets
  • dl-Thioridazine
  • Melleretten
  • Tioridazina
  • Novoridazine
  • Thioridazine prolongatum
  • Thioridazinum
  • Melleryl
  • Orsanil
  • Thioril
  • 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine
  • 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine
  • 3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine
  • 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
  • 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine
  • 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine
Show all 38 synonyms
  • Phenothiazine, 10-((1-methyl-2-piperidyl)ethyl)-2-(methylthio)-
  • ApoThioridazine
  • 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylsulfanyl-phenothiazine
  • 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-methylsulfanylphenothiazine
  • 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine
  • Apo Thioridazine
  • 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylsulfanyl)-10H-phenothiazine
  • Thioridazineneurazpharm
  • Thioridazine neurazpharm
  • 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine
  • Melleril (liquid)
  • 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-
  • (+-)-Thioridazine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from acetoneexp.
Odour
Faintexp.
Taste
Very bitterexp.
Melting point
72 to 74exp.
Boiling point
230 °Cexp.
Solubility
Soluble in alcohol (1 in 6), chloroform (1 in 0.81), ether (1 in 3), freely soluble in dehydrated alcohol. Insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
370.59 g/molcalc.
Exact mass
370.1537 Dacalc.
LogP (octanol/water)
5.89calc.
Topological polar surface area
6.48 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
25calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)Sc1ccccc1N2CCC1CCCCN1

c1ccc2c(c1)Sc1ccccc1N2CCC1CCCCN1

4 rings, 22 atoms.

26 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H400Very toxic to aquatic life.
  • H410Very toxic to aquatic life with long lasting effects.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Thioridazine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 60 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

60 suppliers in 12 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Thioridazine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Indicated for the management of schizophrenic patients who fail to respond adequately to treatment with antipsychotic drugs.

Used in the management of psychoses ... and in the control of severely distured or agitated behavior.

Therapeutic category: Antipsychotic.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Antipsychotic Agents
  • Dopamine Antagonists

Roles

  • H1-receptor antagonist
  • adrenergic agent
  • adrenergic antagonist
  • alpha-adrenergic antagonist
  • alpha-adrenergic drug
  • antagonist
  • antidepressant
  • antineoplastic agent
  • antipsychotic agent
  • anxiolytic drug
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • enzyme inhibitor
  • first generation antipsychotic
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic antagonist
  • serotonergic drug
  • tranquilizing drug

Pharmacology

Thioridazine is a Phenothiazine.

How it is made

2-(Methylthio)phenothiazine, which may be prepared by reacting 2-chlorophenothiazine with (methylthio)sodium, is condensed with 2-(1-methyl-1-piperidyl)ethyl chloride with the aid of a dehydrochlorinating agent such as sodamide.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Thioridazine is traded under.

HS 2934.30Indicative HS code

Compounds containing in the structure a phenothiazine ring-system (whether or not…

World exports in 2024
$89.3M
−7.1% vs 2023, imports $97M
2019 to 2024
Top exporters
  1. Germany21.6%
  2. France * partner reported14.6%
  3. China13.0%
Top importers
  1. United States14.2%
  2. Brazil12.7%
  3. India * partner reported10.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Thioridazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Thioridazine, based on the data on this page

What is Thioridazine?

Thioridazine is a phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.

What is the CAS number of Thioridazine?

The CAS registry number of Thioridazine is 50-52-2. Other or deprecated CAS numbers: 107388-89-6.

What is the molecular formula and weight of Thioridazine?

The molecular formula of Thioridazine is C21H26N2S2 and its molar mass is 370.59 g/mol.

What is Thioridazine used for?

Indicated for the management of schizophrenic patients who fail to respond adequately to treatment with antipsychotic drugs. Used in the management of psychoses ... and in the control of severely distured or agitated behavior. Therapeutic category: Antipsychotic. Use classes: Pharmaceuticals.

Is Thioridazine hazardous?

Thioridazine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, very toxic to aquatic life, very toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Thioridazine?

Thioridazine is usually classified under HS code 293430 (Compounds containing in the structure a phenothiazine ring-system (whether or not…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Thioridazine?

CompoundList lists 60 suppliers of Thioridazine in United States, China, Spain, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Thioridazine in India?

1 supplier in India list Thioridazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Thioridazine?

Suppliers quote Thioridazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Thioridazine

Get quotes for Thioridazine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Thioridazine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Thioridazine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/thioridazine-50-52-2" title="Thioridazine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Central nervous system drugs or HS code 293430

60 suppliers
Free quotes, contact stays private
Get quotes