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Heterocyclic building blocks

Tipiracil

Also known as TPI (freebase), Tipiracilo, 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione

CAS 183204-74-2Formula C9H11ClN4O2Molar mass 242.67 g/mol
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Tipiracil chemical structure, C9H11ClN4O2, CAS 183204-74-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
183204-74-2
Formula
C9H11ClN4O2
Molar mass
242.67 g/mol
HS code
293359
Category
Heterocyclic building blocks

What is Tipiracil?

Plain description, key identifiers and synonyms

Tipiracil is a member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer. It has a role as an antineoplastic agent and an EC 2.4.2.4 (thymidine phosphorylase) inhibitor. It is a carboxamidine, an organochlorine compound, a member of pyrrolidines and a pyrimidone. It is functionally related to a uracil. It is a conjugate base of a tipiracil(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione
CAS number
183204-74-2 CAS number cross-checked
Molecular formula
C9H11ClN4O2
UNII
NGO10K751P
MDL number
MFCD17215839
InChIKey
QQHMKNYGKVVGCZ-UHFFFAOYSA-N
InChI
InChI=1S/C9H11ClN4O2/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11/h11H,1-4H2,(H2,12,13,15,16)
SMILES (canonical and isomeric)
C1CC(=N)N(C1)CC2=C(C(=O)NC(=O)N2)Cl

Synonyms

  • TPI (freebase)
  • Tipiracilo
  • 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione
  • 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4-(1H,3H)-dione
  • 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1h,3h)-pyrimidinedione
  • tipiracilum
  • 5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)-1H-pyrimidine-2,4-dione
  • 5-Chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione
  • 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione
  • 5-Chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4(1H,3H)-dione
  • 5-Chloro-6-(1-(2-iminopyrrolidinyl) methyl) uracil
  • 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • TPI
  • 5-CIMU
  • 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-di
  • 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]pyrimidine-2,4(1H,3H)-dione
  • 5-Chloro-6-{[(2E)-2-imino-1-pyrrolidinyl]methyl}-2,4(1H,3H)-pyrimidinedione
  • 5-chloro-6-{[(2Z)-2-iminopyrrolidin-1-yl]methyl}pyrimidine-2,4(1H,3H)-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
242.67 g/molcalc.
Exact mass
242.0571 Dacalc.
LogP (octanol/water)
0.29calc.
Topological polar surface area
92.81 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
16calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, N=C1CCCN1Cc1cc(=O)[nH]c(=O)[nH]1

N=C1CCCN1Cc1cc(=O)[nH]c(=O)[nH]1

2 rings, 15 atoms, the 6-((2-Iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione (Tipiracil Impurity) ring system.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Tipiracil suppliers

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All 4 suppliers
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Where suppliers are based

4 suppliers in 1 country

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Tipiracil price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Tipiracil is a Thymidine Phosphorylase Inhibitor. The mechanism of action of tipiracil is as a Thymidine Phosphorylase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Tipiracil is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Tipiracil is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Tipiracil, based on the data on this page

What is Tipiracil?

Tipiracil is a member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively.

What is the CAS number of Tipiracil?

The CAS registry number of Tipiracil is 183204-74-2.

What is the molecular formula and weight of Tipiracil?

The molecular formula of Tipiracil is C9H11ClN4O2 and its molar mass is 242.67 g/mol.

What is Tipiracil used for?

Known uses and roles of Tipiracil include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, enzyme inhibitor and pharmaceutical.

Is Tipiracil hazardous?

No GHS hazard classification for Tipiracil is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Tipiracil?

Tipiracil is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Tipiracil?

CompoundList lists 4 suppliers of Tipiracil in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Tipiracil?

Suppliers quote Tipiracil on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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