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Hardeners and crosslinkers

Triethylenephosphoramide

Also known as TEPA, Aphoxide, Tris(1-aziridinyl)phosphine oxide

CAS 545-55-1Formula C6H12N3OPMolar mass 173.16 g/molEC 208-892-5
1 supplier listed
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Triethylenephosphoramide chemical structure, C6H12N3OP, CAS 545-55-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless crystals
Melting point
41 °C
Boiling point
90 to 91 °C
Density
Greater than 1 at 68 °F (est) (USCG, 1999)
Solubility
EXTREMELY SOL IN WATER, VERY SOL IN ALCOHOL, ETHER, ACETONE
HS code
293399
Category
Hardeners and crosslinkers
UN number
UN 2501
Illustrative photo, colourless crystals in small glass vials on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Triethylenephosphoramide?

Plain description, key identifiers and synonyms

Tris(1-aziridinyl)phosphine oxide is a phosphoramide.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[bis(aziridin-1-yl)phosphoryl]aziridine
CAS number
545-55-1 CAS number cross-checkedOther or deprecated CAS: 27030-72-4
EC number
208-892-5
Molecular formula
C6H12N3OP
UNII
GL19M2KE52
InChIKey
FYAMXEPQQLNQDM-UHFFFAOYSA-N
InChI
InChI=1S/C6H12N3OP/c10-11(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
SMILES (canonical and isomeric)
C1CN1P(=O)(N2CC2)N3CC3

Synonyms

  • TEPA
  • Aphoxide
  • Tris(1-aziridinyl)phosphine oxide
  • TAPO
  • Imperon fixer T
  • Triaziridinylphosphine oxide
  • Triaziridinophosphine oxide
  • Triethylenephosphorotriamide
  • Triethylene phophoramide
  • Triethylene phosphoramide
  • Phosphoric acid triethylene imide
  • Tris(1-aziridine)phosphine oxide
  • Tri(aziridin-1-yl)phosphine oxide
  • Triethylenephosphoric triamide
  • ENT 24915
  • Tris(aziridinyl)phosphine oxide
  • Tri-1-aziridinylphosphine oxide
  • Triethylenfosforamid
  • 1,1',1''-Phosphinylidynetrisaziridine
  • Triethylenepyrophosphoramide
  • Triaethylenphosphorsaeureamid
  • Tris(N-ethylene)phosphorotriamidate
  • Aziridine, 1,1',1''-phosphinylidynetris-
  • Phosphine oxide, tris(1-aziridinyl)-
  • CBC 906288
Show all 36 synonyms
  • N,N',N''-Triethylenephosphoric triamide
  • N,N',N''-Triethylenephosphoramide
  • Phosphoric triamide, N,N',N''-tri-1,2-ethanediyl-
  • 1-[bis(aziridin-1-yl)phosphoryl]aziridine
  • APO
  • Tri(1-aziridinyl)phosphine oxide
  • Tepa (possesses cytotoxic activity)
  • TEF
  • Hexamethylphosphoric triamide tris(1-aziridinyl)phosphine oxide
  • TEPA (VAN)
  • Tris-(1-aziridinyl)-phosphineoxide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless crystalsexp.
Melting point
41 °Cexp.
Boiling point
90 to 91 °Cexp.
Density
Greater than 1 at 68 °F (est) (USCG, 1999)exp.
Solubility
EXTREMELY SOL IN WATER, VERY SOL IN ALCOHOL, ETHER, ACETONEexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
173.16 g/molcalc.
Exact mass
173.0718 Dacalc.
LogP (octanol/water)
0.04calc.
Topological polar surface area
26.1 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
3calc.
Heavy atoms
11calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=P(N1CC1)(N1CC1)N1CC1

O=P(N1CC1)(N1CC1)N1CC1

3 rings, 11 atoms. This chemical is the scaffold itself.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms
UN number
UN 2501
Transport hazard class
6.1

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Triethylenephosphoramide suppliers

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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

1 supplier in 1 country

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Triethylenephosphoramide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Flame retardant for cotton, chemosterilant for insects, pesticide for mites & ticks, photographic emulsion hardener, agent in the permanent press treatment of cotton, agent in textile dyeing, & agent for polymer stabilization are former uses.

Not used commercially in us.

Veterinary medication:.

Use classes: Chemosterilants.

Pharmacological actions

  • Antineoplastic Agents, Alkylating

How it is made

Addition of ethyleneimine to phosphorus oxychloride in the presence of a base (former process)

Bestian, ann 566, 231 (1950).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Triethylenephosphoramide is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Triethylenephosphoramide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Triethylenephosphoramide, based on the data on this page

What is Triethylenephosphoramide?

Tris(1-aziridinyl)phosphine oxide is a phosphoramide.

What is the CAS number of Triethylenephosphoramide?

The CAS registry number of Triethylenephosphoramide is 545-55-1. Other or deprecated CAS numbers: 27030-72-4.

What is the molecular formula and weight of Triethylenephosphoramide?

The molecular formula of Triethylenephosphoramide is C6H12N3OP and its molar mass is 173.16 g/mol.

What is Triethylenephosphoramide used for?

Flame retardant for cotton, chemosterilant for insects, pesticide for mites & ticks, photographic emulsion hardener, agent in the permanent press treatment of cotton, agent in textile dyeing, & agent for polymer stabilization are former uses. Not used commercially in us. Veterinary medication:.

Is Triethylenephosphoramide hazardous?

No GHS hazard classification for Triethylenephosphoramide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Triethylenephosphoramide?

Triethylenephosphoramide is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Triethylenephosphoramide?

CompoundList lists 1 supplier of Triethylenephosphoramide in China. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Triethylenephosphoramide?

Suppliers quote Triethylenephosphoramide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Triethylenephosphoramide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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