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Heterocyclic building blocks

Trofosfamide

Also known as Ixoten, Trophosphamide, Trofosfamid

CAS 22089-22-1Formula C9H18Cl3N2O2PMolar mass 323.59 g/molEC 244-770-8
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard 2 suppliers listed
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Trofosfamide chemical structure, C9H18Cl3N2O2P, CAS 22089-22-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
22089-22-1
Formula
C9H18Cl3N2O2P
Molar mass
323.59 g/mol
EC number
244-770-8
HS code
293499
Category
Heterocyclic building blocks

What is Trofosfamide?

Plain description, key identifiers and synonyms

Trofosfamide is a member of ifosfamides.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2ฮป5-oxazaphosphinan-2-amine
CAS number
22089-22-1 CAS number cross-checkedOther or deprecated CAS: 72282-84-9, 72282-85-0
EC number
244-770-8
Molecular formula
C9H18Cl3N2O2P
UNII
H64JRU6GJ0
MDL number
MFCD00866435
InChIKey
UMKFEPPTGMDVMI-UHFFFAOYSA-N
InChI
InChI=1S/C9H18Cl3N2O2P/c10-2-6-13-5-1-9-16-17(13,15)14(7-3-11)8-4-12/h1-9H2
SMILES (canonical and isomeric)
C1CN(P(=O)(OC1)N(CCCl)CCCl)CCCl

Synonyms

  • Ixoten
  • Trophosphamide
  • Trofosfamid
  • Trilophosphamide
  • Trofosfamida
  • Trofosfamidum
  • N,N,3-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
  • N,N-3'-Tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine, 2-oxide
  • N,N,N'-Tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide
  • Genoxal Trofosfamida
  • N,N,N'-tris(2-chloroethyl)-N'-O-propylene phosphoric acid ester diamide
  • 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)-1,3,2lambda5-oxazaphosphinan-2-one
  • 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide
  • Trifosfamide
  • ASTA Z 4828
  • N,N,3-tris(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine
  • 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide
  • Trofosfamide (INN)
  • 3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide
  • Trilofosfamida
  • Triphosphamide
  • Trisfosfamide
  • Trophosphamid
  • TFF
  • Trofosfamido
Show all 30 synonyms
  • C9H18Cl3N2O2P
  • N,N,N'-Tris(2-chloraethyl)-N',O-propylen-phosphorsaureester-diamid
  • 2-(Bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
  • 2H-1,3,2-Oxazaphosphorin-2-amine, N,N,3-tris(2-chloroethyl)tetrahydro-, 2-oxide
  • 3-(2-Chloroethyl)-2-(bis(2-chloroethyl)amino)perhydro-2H-1,3,2-oxazaphosphorine 2-oxide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
323.59 g/molcalc.
Exact mass
322.0171 Dacalc.
LogP (octanol/water)
2.84calc.
Topological polar surface area
32.78 ร…ยฒcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
7calc.
Heavy atoms
17calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=[PH]1NCCCO1

O=[PH]1NCCCO1

1 ring, 7 atoms.

197 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H340May cause genetic defects.
  • H350May cause cancer.
  • H360May damage fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (13)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Trofosfamide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers
  • AChemBlock
    United States, HaywardUnclaimed profile
    TrofosfamideGrade, purity and minimum order on request
    Price on request
    View
  • EvitaChem
    China, BeijingUnclaimed profile
    TrofosfamideGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Trofosfamide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents, Alkylating
  • Immunosuppressive Agents
  • Mutagens

Roles

  • antineoplastic agent
  • pharmaceutical

Pharmacology

Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Trofosfamide is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Trofosfamide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Trofosfamide, based on the data on this page

What is Trofosfamide?

Trofosfamide is a member of ifosfamides.

What is the CAS number of Trofosfamide?

The CAS registry number of Trofosfamide is 22089-22-1. Other or deprecated CAS numbers: 72282-84-9, 72282-85-0.

What is the molecular formula and weight of Trofosfamide?

The molecular formula of Trofosfamide is C9H18Cl3N2O2P and its molar mass is 323.59 g/mol.

What is Trofosfamide used for?

Known uses and roles of Trofosfamide include building blocks in research and laboratory, antineoplastic agent, pharmaceutical, antineoplastic agents, alkylating, immunosuppressive agents and 1 more.

Is Trofosfamide hazardous?

Trofosfamide carries the GHS signal word "Danger". Main hazards: toxic if swallowed, may cause genetic defects, may cause cancer. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Trofosfamide?

Trofosfamide is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclicโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Trofosfamide?

CompoundList lists 2 suppliers of Trofosfamide in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Trofosfamide?

Suppliers quote Trofosfamide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Trofosfamide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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