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Heterocyclic building blocks

Voxtalisib

Also known as 2-amino-8-ethyl-4-methyl-6-(1h-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8h)-one, Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-, Pyrido(2,3-d)pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-

CAS 934493-76-2Formula C13H14N6OMolar mass 270.30 g/mol
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Voxtalisib chemical structure, C13H14N6O, CAS 934493-76-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
934493-76-2
Formula
C13H14N6O
Molar mass
270.30 g/mol
HS code
293359
Category
Heterocyclic building blocks

What is Voxtalisib?

Plain description, key identifiers and synonyms

2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone is a pyrazolopyridine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7-one
CAS number
934493-76-2 CAS number cross-checked
Molecular formula
C13H14N6O
UNII
CVL1685GPH
MDL number
MFCD28716102
InChIKey
RGHYDLZMTYDBDT-UHFFFAOYSA-N
InChI
InChI=1S/C13H14N6O/c1-3-19-11-8(7(2)16-13(14)17-11)6-9(12(19)20)10-4-5-15-18-10/h4-6H,3H2,1-2H3,(H,15,18)(H2,14,16,17)
SMILES (canonical and isomeric)
CCN1C2=NC(=NC(=C2C=C(C1=O)C3=CC=NN3)C)N

Synonyms

  • 2-amino-8-ethyl-4-methyl-6-(1h-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8h)-one
  • Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-
  • Pyrido(2,3-d)pyrimidin-7(8H)-one, 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)-
  • voxtalisibum
  • 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido(2,3-d)pyrimidin-7(8H)-one
  • 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7H,8H-pyrido(2,3-d)pyrimidin-7-one
  • N-(4-((3-((3,5-dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide
  • N-(4-((3-(3,5-dimethoxyanilino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylbenzamide
  • XL 765
  • Xl-765
  • 2-amino-8-ethyl-4-methyl-6-(1h-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8h)-one
  • Voxtalisib (XL765)
  • 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7-one
  • 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido(2,3-d)pyrimidin-7(8H)-one
  • Voxtalisib (USAN/INN)
  • Voxtalisib (XL-765)
  • Voxtalisib (XL765, SAR245409)?
  • 2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-3-yl)pyrido(2,3-d)pyrimidin-
  • 2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
270.30 g/molcalc.
Exact mass
270.1229 Dacalc.
LogP (octanol/water)
1.09calc.
Topological polar surface area
102.5 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1[nH]c2ncncc2cc1-c1ccn[nH]1

O=c1[nH]c2ncncc2cc1-c1ccn[nH]1

3 rings, 16 atoms.

4 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Voxtalisib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

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  • Axon Medchem
    United States, RestonUnclaimed profile
    VoxtalisibGrade, purity and minimum order on request
    Price on request
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Where suppliers are based

1 supplier in 1 country

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Voxtalisib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • lipid kinase inhibitor
  • mTOR inhibitor
  • pharmaceutical
  • protein kinase inhibitor

Pharmacology

Voxtalisib is an orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Voxtalisib inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy, mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion in response to nutrient and energy deprivation. Accordingly, this agent maybe more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Voxtalisib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Voxtalisib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Voxtalisib, based on the data on this page

What is Voxtalisib?

2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone is a pyrazolopyridine.

What is the CAS number of Voxtalisib?

The CAS registry number of Voxtalisib is 934493-76-2.

What is the molecular formula and weight of Voxtalisib?

The molecular formula of Voxtalisib is C13H14N6O and its molar mass is 270.30 g/mol.

What is Voxtalisib used for?

Known uses and roles of Voxtalisib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, enzyme inhibitor, lipid kinase inhibitor and 3 more.

Is Voxtalisib hazardous?

No GHS hazard classification for Voxtalisib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Voxtalisib?

Voxtalisib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Voxtalisib?

CompoundList lists 1 supplier of Voxtalisib in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Voxtalisib?

Suppliers quote Voxtalisib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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