Zinostatin stimalamer
Also known as Smancs, YM 881, Poly(maleic acid-styrene)neocarzinostatin
Key facts
What buyers check first
- CAS number
- 123760-07-6
- Formula
- C36H35NO11
- Molar mass
- 657.67 g/mol
- HS code
- 293299
- Category
- Polymers and thermoplastics
What is Zinostatin stimalamer?
Plain description, key identifiers and synonyms
Zinostatin Stimalamer is a highly lipophilic conjugate protein comprised of the lipophilic antitumor protein, neocarzinostatin (NCS), conjugated with a water-soluble copolymer of styrene-maleic acid (SMA) with potential antineoplastic activity. Upon intra-hepatic arterial administration, zinostatin stimalamer is deposited within tumor tissues, where the NCS moiety induces sequence-specific single and double-stranded breaks via free-radical based mechanisms, resulting in tumor cell death.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- [(4S,6R,9E,12R)-11-[(2R,3R,4R,5R,6R)-4,5-dihydroxy-6-methyl-3-(methylamino)oxan-2-yl]oxy-4-[(4S)-2-oxo-1,3-dioxolan-4-yl]-5-oxatricyclo[8.3.0.04,6]trideca-1(13),9-dien-2,7-diyn-12-yl] 7-methoxy-2,5-dimethylnaphthalene-1-carboxylate
- CAS number
- 123760-07-6
- Molecular formula
- C36H35NO11
- InChIKey
- FYQZGCBXYVWXSP-STTFAQHVSA-N
- InChI
- InChI=1S/C36H35NO11/c1-17-9-10-22-18(2)13-21(42-5)15-24(22)28(17)33(40)45-25-14-20-11-12-36(27-16-43-35(41)46-27)26(48-36)8-6-7-23(20)32(25)47-34-29(37-4)31(39)30(38)19(3)44-34/h7,9-10,13-15,19,25-27,29-32,34,37-39H,16H2,1-5H3/b23-7+/t19-,25-,26-,27+,29-,30+,31-,32?,34-,36+/m1/s1
- Canonical SMILES
- CNC1C(OC2C3=CC#CC4OC4(C4COC(=O)O4)C#CC3=CC2OC(=O)c2c(C)ccc3c(C)cc(OC)cc23)OC(C)C(O)C1O
- Isomeric SMILES
- C[C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)OC\2[C@@H](C=C3/C2=C\C#C[C@@H]4[C@@](O4)(C#C3)[C@@H]5COC(=O)O5)OC(=O)C6=C(C=CC7=C6C=C(C=C7C)OC)C)NC)O)O
Synonyms
- Smancs
- YM 881
- Poly(maleic acid-styrene)neocarzinostatin
- copoly(styrene-maleic acid)neocarzinostatin
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 657.67 g/molcalc.Computed value |
|---|---|
| Exact mass | 657.221 Dacalc.Computed value |
| LogP (octanol/water) | 1.99calc.Computed value |
| Topological polar surface area | 154.5 Ųcalc.Computed value |
| Hydrogen bond donors | 3calc.Computed value |
| Hydrogen bond acceptors | 12calc.Computed value |
| Rotatable bonds | 7calc.Computed value |
| Heavy atoms | 48calc.Computed value |
| Rings | 7calc.Computed value |
| Aromatic rings | 2calc.Computed value |
| Fraction sp3 carbons | 0.44calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 10calc.Computed value |
| Lipinski rule of five | Fails (2 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C1OCC(C23C#CC4=CC(OC(=O)c5cccc6ccccc56)C(OC5CCCCO5)C4=CC#CC2O3)O1
7 rings, 39 atoms.
1 other chemical share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Zinostatin stimalamer suppliers
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Zinostatin stimalamer price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Pharmacological actions
- Antineoplastic Agents
Regulatory status
Inventories, regulations and trade controls that list this substance
No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Zinostatin stimalamer is traded under.
Heterocyclic compounds with oxygen hetero-atom(s) only, other
- China28.9%
- Switzerland * partner reported12.7%
- Germany7.8%
- United States49.7%
- China11.9%
- India * partner reported3.3%
* Partner reported figures, a lower bound.
The HS code shown for Zinostatin stimalamer is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
Frequently asked questions
Quick answers about Zinostatin stimalamer, based on the data on this page
What is Zinostatin stimalamer?
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What is Zinostatin stimalamer used for?
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What is the HS code of Zinostatin stimalamer?
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Guides for buyers
Practical guides that help when you source, ship or handle Zinostatin stimalamer
- Article, QualityWhat a certificate of analysis should containThe parts of a complete COA, how to read it against your specification, the warning signs of a weak or copied certificate and how to verify results.Read
- Article, SourcingHow to write an RFQ that gets fast and accurate quotesWhat suppliers need to quote quickly and comparably: exact product identity, quantity and packing, delivery terms, documents, samples and payment, with a ready to use template.Read
- Guide, Trade and logisticsHS codes for chemicals and why they matterHow the Harmonized System classifies chemicals, the chapters that matter, the rules for chemically defined compounds and mixtures, and practical steps to find the right code.Read
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