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Murcko scaffold

Ring system with 4 rings and 24 atoms

18 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 18
With full pages: 15

Scaffold SMILES

O=C1Nc2ccccc2C1=C1SC(=S)N(Cc2ccccc2)C1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1Nc2ccccc2C1=C1SC(=S)N(Cc2ccccc2)C1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

(5Z)-5-(1-Acetyl-2-oxoindol-3-ylidene)-3-benzyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H14N2O3S2, CAS 303798-55-2

(5Z)-5-(1-Acetyl-2-oxoindol-3-ylidene)-3-benzyl-2-sulfanylidene-1,3-thiazolidin-4-one

CAS 303798-55-2C₂₀H₁₄N₂O₃S₂

(3Z)-1-Allyl-3-(3-benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C21H16N2O2S2, CAS 324565-26-6

(3Z)-1-Allyl-3-(3-benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one

CAS 324565-26-6C₂₁H₁₆N₂O₂S₂

2-[(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetamide chemical structure, C20H15N3O3S2, CAS 373374-34-6

2-[(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-2-oxo-2,3-dihydro-1H-indol-1-yl]acetamide

CAS 373374-34-6C₂₀H₁₅N₃O₃S₂

(3Z)-5-Bromo-1-ethyl-3-[3-(4-methoxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C21H17BrN2O3S2, CAS 865593-07-3

(3Z)-5-Bromo-1-ethyl-3-[3-(4-methoxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one

CAS 865593-07-3C₂₁H₁₇BrN₂O₃S₂

(3Z)-5-Bromo-1-butyl-3-(3-(4-methoxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C23H21BrN2O3S2, CAS 618077-65-9

(3Z)-5-Bromo-1-butyl-3-(3-(4-methoxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one

CAS 618077-65-9C₂₃H₂₁BrN₂O₃S₂

(3Z)-5-Bromo-1-butyl-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C22H18BrFN2O2S2, CAS 618081-37-1

(3Z)-5-Bromo-1-butyl-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one

CAS 618081-37-1C₂₂H₁₈BrFN₂O₂S₂

(3Z)-5-Bromo-1-butyl-3-[3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C23H21BrN2O2S2, CAS 618075-24-4

(3Z)-5-Bromo-1-butyl-3-[3-(4-methylbenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one

CAS 618075-24-4C₂₃H₂₁BrN₂O₂S₂

(3Z)-5-Bromo-3-(3-(2-chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-ethyl-1,3-dihydro-2H-indol-2-one chemical structure, C20H14BrClN2O2S2, CAS 617697-89-9

(3Z)-5-Bromo-3-(3-(2-chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-ethyl-1,3-dihydro-2H-indol-2-one

CAS 617697-89-9C₂₀H₁₄BrClN₂O₂S₂

(3Z)-5-Bromo-1-ethyl-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C21H17BrN2O2S2, CAS 617698-18-7

(3Z)-5-Bromo-1-ethyl-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one

CAS 617698-18-7C₂₁H₁₇BrN₂O₂S₂

(3Z)-5-Bromo-1-ethyl-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C20H14BrFN2O2S2, CAS 617697-76-4

(3Z)-5-Bromo-1-ethyl-3-(3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one

CAS 617697-76-4C₂₀H₁₄BrFN₂O₂S₂

(3Z)-5-Bromo-3-(3-(2-chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C21H16BrClN2O2S2, CAS 617696-86-3

(3Z)-5-Bromo-3-(3-(2-chlorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-propyl-1,3-dihydro-2H-indol-2-one

CAS 617696-86-3C₂₁H₁₆BrClN₂O₂S₂

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C21H17BrN2O2S2, CAS 617698-16-5

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1-propyl-1,3-dihydro-2H-indol-2-one

CAS 617698-16-5C₂₁H₁₇BrN₂O₂S₂

(3Z)-5-Bromo-3-[3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C21H16BrFN2O2S2, CAS 617696-26-1

(3Z)-5-Bromo-3-[3-(4-fluorobenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene]-1-propyl-1,3-dihydro-2H-indol-2-one

CAS 617696-26-1C₂₁H₁₆BrFN₂O₂S₂

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1-ethyl-1,3-dihydro-2H-indol-2-one chemical structure, C20H15BrN2O2S2, CAS 617697-80-0

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1-ethyl-1,3-dihydro-2H-indol-2-one

CAS 617697-80-0C₂₀H₁₅BrN₂O₂S₂

(3Z)-5-Bromo-1-butyl-3-[4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one chemical structure, C23H21BrN2O2S2, CAS 618077-70-6

(3Z)-5-Bromo-1-butyl-3-[4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene]-1,3-dihydro-2H-indol-2-one

CAS 618077-70-6C₂₃H₂₁BrN₂O₂S₂

(3Z)-5-Bromo-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H19BrN2O2S2, CAS 617696-16-9

(3Z)-5-Bromo-3-(4-oxo-3-(1-phenylethyl)-2-thioxo-1,3-thiazolidin-5-ylidene)-1-propyl-1,3-dihydro-2H-indol-2-one

CAS 617696-16-9C₂₂H₁₉BrN₂O₂S₂

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1-butyl-1,3-dihydro-2H-indol-2-one chemical structure, C22H19BrN2O2S2, CAS 618077-67-1

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1-butyl-1,3-dihydro-2H-indol-2-one

CAS 618077-67-1C₂₂H₁₉BrN₂O₂S₂

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-propyl-1,3-dihydro-2H-indol-2-one chemical structure, C21H18N2O2S2, CAS 331852-12-1

(3Z)-3-(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1-propyl-1,3-dihydro-2H-indol-2-one

CAS 331852-12-1C₂₁H₁₈N₂O₂S₂