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Murcko scaffold

Ring system with 4 rings and 21 atoms

8 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
21
Chemicals
8
With full pages
2
Scaffold SMILES

c1ccc(CC2CCC(n3ccc4cncnc43)O2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CC2CCC(n3ccc4cncnc43)O2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

7-[(5R)-5-C-(4-Chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C17H17ClN4O4, CAS 1989620-03-2
7-[(5R)-5-C-(4-Chlorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1989620-03-2C17H17ClN4O4
Prmt5-IN-2 chemical structure, C17H16ClFN4O4, CAS 1989620-04-3
Prmt5-IN-2
CAS 1989620-04-3C17H16ClFN4O4
Lly-283 chemical structure, C17H18N4O4, CAS 2040291-27-6
Lly-283
CAS 2040291-27-6C17H18N4O4
Prmt5-IN-28 chemical structure, C18H19ClN4O5, CAS 2242753-66-6
Prmt5-IN-28
CAS 2242753-66-6C18H19ClN4O5
(2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol chemical structure, C17H18N4O4, CAS 2226515-75-7
(2R,3R,4S,5R)-2-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-((S)-hydroxy(phenyl)methyl)tetrahydrofuran-3,4-diol
CAS 2226515-75-7C17H18N4O4
(2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((S)-(3,4-dichlorophenyl)(hydroxy)methyl)-3-methyltetrahydrofuran-3,4-diol chemical structure, C18H18Cl2N4O4, CAS 2278357-03-0
(2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-((S)-(3,4-dichlorophenyl)(hydroxy)methyl)-3-methyltetrahydrofuran-3,4-diol
CAS 2278357-03-0C18H18Cl2N4O4
Prmt5-IN-14 chemical structure, C18H18Cl2N4O4, CAS 2278356-90-2
Prmt5-IN-14
CAS 2278356-90-2C18H18Cl2N4O4
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-(4-chloro-3-fluorophenyl)-hydroxymethyl]oxolane-3,4-diol, hydrate chemical structure, C17H18ClFN4O5, CAS 3096651-03-2
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-(4-chloro-3-fluorophenyl)-hydroxymethyl]oxolane-3,4-diol, hydrate
CAS 3096651-03-2C17H18ClFN4O5