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Murcko scaffold

Ring system with 2 rings and 12 atoms

57 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
57
With full pages
14
Scaffold SMILES

c1ccc(-c2nccnn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2nccnn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 57 chemicals

1-Methyl-3-phenyl-1,2,4-triazin-5-one chemical structure, C10H9N3O, CAS 113342-81-7
1-Methyl-3-phenyl-1,2,4-triazin-5-one
CAS 113342-81-7C10H9N3O
1,2,4-Triazine-6-carboxylic acid, 5-chloro-3-phenyl-, ethyl ester chemical structure, C12H10ClN3O2, CAS 37539-91-6
1,2,4-Triazine-6-carboxylic acid, 5-chloro-3-phenyl-, ethyl ester
CAS 37539-91-6C12H10ClN3O2
Diethyl 3-phenyl-1,2,4-triazine-5,6-dicarboxylate chemical structure, C15H15N3O4, CAS 24108-45-0
Diethyl 3-phenyl-1,2,4-triazine-5,6-dicarboxylate
CAS 24108-45-0C15H15N3O4
Ethyl 2-{[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]sulfanyl}acetate chemical structure, C14H12F3N3O2S, CAS 383148-42-3
Ethyl 2-{[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]sulfanyl}acetate
CAS 383148-42-3C14H12F3N3O2S
N-Methyl-3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-amine chemical structure, C11H9F3N4, CAS 383148-46-7
N-Methyl-3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-amine
CAS 383148-46-7C11H9F3N4
N,N-Dimethyl-3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-amine chemical structure, C12H11F3N4, CAS 478048-15-6
N,N-Dimethyl-3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-amine
CAS 478048-15-6C12H11F3N4
Methyl 5-methoxy-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C12H11N3O3, CAS 338956-86-8
Methyl 5-methoxy-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338956-86-8C12H11N3O3
Isopropyl 5-isopropoxy-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C16H19N3O3, CAS 338956-98-2
Isopropyl 5-isopropoxy-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 338956-98-2C16H19N3O3
5-Methoxy-3-phenyl-1,2,4-triazine-6-carboxylic acid chemical structure, C11H9N3O3, CAS 439111-01-0
5-Methoxy-3-phenyl-1,2,4-triazine-6-carboxylic acid
CAS 439111-01-0C11H9N3O3
5-Chloro-6-methyl-3-phenyl-1,2,4-triazine chemical structure, C10H8ClN3, CAS 94398-25-1
5-Chloro-6-methyl-3-phenyl-1,2,4-triazine
CAS 94398-25-1C10H8ClN3
N,N,6-trimethyl-3-phenyl-1,2,4-triazin-5-amine chemical structure, C12H14N4, CAS 339013-26-2
N,N,6-trimethyl-3-phenyl-1,2,4-triazin-5-amine
CAS 339013-26-2C12H14N4
Ethyl 5-(methylamino)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C13H14N4O2, CAS 866051-60-7
Ethyl 5-(methylamino)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 866051-60-7C13H14N4O2
Ethyl 5-(methoxyamino)-3-phenyl-1,2,4-triazine-6-carboxylate chemical structure, C13H14N4O3, CAS 866051-61-8
Ethyl 5-(methoxyamino)-3-phenyl-1,2,4-triazine-6-carboxylate
CAS 866051-61-8C13H14N4O3
N~1~-[3-(4-chlorophenyl)-6-methyl-1,2,4-triazin-5-yl]-N~2~,N~2~-dimethyl-1,2-ethanediamine chemical structure, C14H18ClN5, CAS 866039-25-0
N~1~-[3-(4-chlorophenyl)-6-methyl-1,2,4-triazin-5-yl]-N~2~,N~2~-dimethyl-1,2-ethanediamine
CAS 866039-25-0C14H18ClN5
2-Chloro-N'-methyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]acetohydrazide chemical structure, C13H11ClF3N5O, CAS 672951-02-9
2-Chloro-N'-methyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]acetohydrazide
CAS 672951-02-9C13H11ClF3N5O
Methyl 5-methoxy-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate chemical structure, C13H13N3O3, CAS 126542-67-4
Methyl 5-methoxy-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylate
CAS 126542-67-4C13H13N3O3
N~1~,N~1~-diethyl-N~2~-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]-1,2-ethanediamine chemical structure, C16H20F3N5, CAS 383148-74-1
N~1~,N~1~-diethyl-N~2~-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]-1,2-ethanediamine
CAS 383148-74-1C16H20F3N5
N~1~,N~1~-dimethyl-N~2~-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]-1,2-ethanediamine chemical structure, C14H16F3N5, CAS 672950-90-2
N~1~,N~1~-dimethyl-N~2~-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]-1,2-ethanediamine
CAS 672950-90-2C14H16F3N5
N',3-dimethyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]butanohydrazide chemical structure, C16H18F3N5O, CAS 672951-03-0
N',3-dimethyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]butanohydrazide
CAS 672951-03-0C16H18F3N5O
N-tert-Butyl-6-methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-amine chemical structure, C15H17F3N4, CAS 339103-65-0
N-tert-Butyl-6-methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-amine
CAS 339103-65-0C15H17F3N4
N',2,2-trimethyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]propanohydrazide chemical structure, C16H18F3N5O, CAS 672951-04-1
N',2,2-trimethyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]propanohydrazide
CAS 672951-04-1C16H18F3N5O
N'-Methyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]pentanohydrazide chemical structure, C16H18F3N5O, CAS 672951-07-4
N'-Methyl-N'-[3-phenyl-6-(trifluoromethyl)-1,2,4-triazin-5-yl]pentanohydrazide
CAS 672951-07-4C16H18F3N5O
3-(4-Chlorophenyl)-5-methoxy-6-methyl-1,2,4-triazine chemical structure, C11H10ClN3O, CAS 866039-26-1
3-(4-Chlorophenyl)-5-methoxy-6-methyl-1,2,4-triazine
CAS 866039-26-1C11H10ClN3O
N-Allyl-6-methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-amine chemical structure, C14H13F3N4, CAS 339103-63-8
N-Allyl-6-methyl-3-[3-(trifluoromethyl)phenyl]-1,2,4-triazin-5-amine
CAS 339103-63-8C14H13F3N4