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Murcko scaffold

2,5-Piperazinedione, 3-(phenylmethylene)-, (Z)- scaffold

21 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
15
Chemicals
21
With full pages
5
Scaffold SMILES

O=C1CNC(=O)C(=Cc2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,5-Piperazinedione, 3-(phenylmethylene)-, (Z)- page
Murcko scaffold O=C1CNC(=O)C(=Cc2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 21 of 21 chemicals

2,5-Piperazinedione, 3-(phenylmethylene)-, (Z)- chemical structure, C11H10N2O2, CAS 19459-03-1
2,5-Piperazinedione, 3-(phenylmethylene)-, (Z)-
CAS 19459-03-1C11H10N2O2
1-Acetyl-3-benzylidene-2,5-piperazinedione chemical structure, C13H12N2O3, CAS 30166-30-4
1-Acetyl-3-benzylidene-2,5-piperazinedione
CAS 30166-30-4C13H12N2O3
(3E)-1-Acetyl-3-[(4-methoxyphenyl)methylidene]piperazine-2,5-dione chemical structure, C14H14N2O4, CAS 74720-30-2
(3E)-1-Acetyl-3-[(4-methoxyphenyl)methylidene]piperazine-2,5-dione
CAS 74720-30-2C14H14N2O4
(3E)-1-Acetyl-3-[(4-methoxyphenyl)methylidene]-4-methylpiperazine-2,5-dione chemical structure, C15H16N2O4, CAS 338416-26-5
(3E)-1-Acetyl-3-[(4-methoxyphenyl)methylidene]-4-methylpiperazine-2,5-dione
CAS 338416-26-5C15H16N2O4
(6E)-6-[(4-Methoxyphenyl)methylidene]-1-methylpiperazine-2,5-dione chemical structure, C13H14N2O3, CAS 338416-40-3
(6E)-6-[(4-Methoxyphenyl)methylidene]-1-methylpiperazine-2,5-dione
CAS 338416-40-3C13H14N2O3
(Z)-1-Acetyl-3-benzylidenepiperazine-2,5-dione chemical structure, C13H12N2O3, CAS 30166-29-1
(Z)-1-Acetyl-3-benzylidenepiperazine-2,5-dione
CAS 30166-29-1C13H12N2O3
(3E)-1-Acetyl-4-ethyl-3-[(4-methoxyphenyl)methylidene]piperazine-2,5-dione chemical structure, C16H18N2O4, CAS 338402-35-0
(3E)-1-Acetyl-4-ethyl-3-[(4-methoxyphenyl)methylidene]piperazine-2,5-dione
CAS 338402-35-0C16H18N2O4
(3E)-3-[(4-Methoxyphenyl)methylidene]piperazine-2,5-dione chemical structure, C12H12N2O3, CAS 74720-31-3
(3E)-3-[(4-Methoxyphenyl)methylidene]piperazine-2,5-dione
CAS 74720-31-3C12H12N2O3
1-Acetyl-3-(phenylmethylidene)piperazine-2,5-dione chemical structure, C13H12N2O3
1-Acetyl-3-(phenylmethylidene)piperazine-2,5-dione
C13H12N2O3
3-{[4-(Dimethylamino)phenyl]methylene}tetrahydro-2,5-pyrazinedione chemical structure, C13H15N3O2, CAS 313951-83-6
3-{[4-(Dimethylamino)phenyl]methylene}tetrahydro-2,5-pyrazinedione
CAS 313951-83-6C13H15N3O2
1-Acetyl-3-{[4-(dimethylamino)phenyl]methylene}tetrahydro-2,5-pyrazinedione chemical structure, C15H17N3O3, CAS 117563-26-5
1-Acetyl-3-{[4-(dimethylamino)phenyl]methylene}tetrahydro-2,5-pyrazinedione
CAS 117563-26-5C15H17N3O3
(3E)-3-[(4-Fluorophenyl)methylidene]piperazine-2,5-dione chemical structure, C11H9FN2O2, CAS 155527-35-8
(3E)-3-[(4-Fluorophenyl)methylidene]piperazine-2,5-dione
CAS 155527-35-8C11H9FN2O2
(3E)-1-Acetyl-3-[(4-fluorophenyl)methylidene]piperazine-2,5-dione chemical structure, C13H11FN2O3, CAS 155527-25-6
(3E)-1-Acetyl-3-[(4-fluorophenyl)methylidene]piperazine-2,5-dione
CAS 155527-25-6C13H11FN2O3
Mycelianamide chemical structure, C22H28N2O5, CAS 22775-52-6
Mycelianamide
CAS 22775-52-6C22H28N2O5
4-Methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione chemical structure, C16H20N2O5, CAS 120040-29-1
4-Methyl-3-(2,4,5-trimethoxy-3-methylphenylmethyl)-2,5-piperazinedione
CAS 120040-29-1C16H20N2O5
3-(Phenylmethylene)tetrahydro-2,5-pyrazinedione chemical structure, C11H10N2O2, CAS 63822-72-0
3-(Phenylmethylene)tetrahydro-2,5-pyrazinedione
CAS 63822-72-0C11H10N2O2
3-[(3-Chlorophenyl)methylidene]piperazine-2,5-dione chemical structure, C11H9ClN2O2, CAS 142226-55-9
3-[(3-Chlorophenyl)methylidene]piperazine-2,5-dione
CAS 142226-55-9C11H9ClN2O2
1-Acetyl-3-benzylidene-4-methylpiperazine-2,5-dione chemical structure, C14H14N2O3, CAS 80687-66-7
1-Acetyl-3-benzylidene-4-methylpiperazine-2,5-dione
CAS 80687-66-7C14H14N2O3
1-Acetyl-3-[(2,5-dimethoxyphenyl)methylidene]piperazine-2,5-dione chemical structure, C15H16N2O5, CAS 114912-57-1
1-Acetyl-3-[(2,5-dimethoxyphenyl)methylidene]piperazine-2,5-dione
CAS 114912-57-1C15H16N2O5
(6R)-3-Benzylidene-6-methylpiperazine-2,5-dione chemical structure, C12H12N2O2, CAS 88547-16-4
(6R)-3-Benzylidene-6-methylpiperazine-2,5-dione
CAS 88547-16-4C12H12N2O2
Hdac8-IN-12 chemical structure, C16H17N3O5, CAS 3028095-13-5
Hdac8-IN-12
CAS 3028095-13-5C16H17N3O5