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Murcko scaffold

Ring system with 2 rings and 14 atoms

36 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
36
With full pages
12
Scaffold SMILES

S=C(c1ccccc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=C(c1ccccc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

(4-Ethylpiperazin-1-yl)(4-methoxyphenyl)methanethione chemical structure, C14H20N2OS, CAS 524037-29-4
(4-Ethylpiperazin-1-yl)(4-methoxyphenyl)methanethione
CAS 524037-29-4C14H20N2OS
N,N-Dimethyl-4-(piperazin-1-ylcarbonothioyl)aniline chemical structure, C13H19N3S, CAS 431884-69-4
N,N-Dimethyl-4-(piperazin-1-ylcarbonothioyl)aniline
CAS 431884-69-4C13H19N3S
1-[4-(3-Nitrobenzenecarbothioyl)piperazin-1-yl]ethan-1-one chemical structure, C13H15N3O3S, CAS 433262-03-4
1-[4-(3-Nitrobenzenecarbothioyl)piperazin-1-yl]ethan-1-one
CAS 433262-03-4C13H15N3O3S
1-Acetyl-4-[(4-nitrophenyl)carbonothioyl]piperazine chemical structure, C13H15N3O3S, CAS 433322-46-4
1-Acetyl-4-[(4-nitrophenyl)carbonothioyl]piperazine
CAS 433322-46-4C13H15N3O3S
(4-Methoxyphenyl)-(4-methyl-1-piperazinyl)methanethione chemical structure, C13H18N2OS, CAS 676588-07-1
(4-Methoxyphenyl)-(4-methyl-1-piperazinyl)methanethione
CAS 676588-07-1C13H18N2OS
2-[4-(4-Chlorobenzothioyl)-1-piperazinyl]ethanol chemical structure, C13H17ClN2OS, CAS 500106-30-9
2-[4-(4-Chlorobenzothioyl)-1-piperazinyl]ethanol
CAS 500106-30-9C13H17ClN2OS
(4-Bromophenyl)(4-methylpiperazin-1-yl)methanethione chemical structure, C12H15BrN2S, CAS 675190-35-9
(4-Bromophenyl)(4-methylpiperazin-1-yl)methanethione
CAS 675190-35-9C12H15BrN2S
4-[(4-Methyl-1-piperazinyl)carbothioyl]phenol chemical structure, C12H16N2OS, CAS 500269-91-0
4-[(4-Methyl-1-piperazinyl)carbothioyl]phenol
CAS 500269-91-0C12H16N2OS
(4-Ethoxyphenyl)(4-ethylpiperazin-1-yl)methanethione chemical structure, C15H22N2OS, CAS 678548-02-2
(4-Ethoxyphenyl)(4-ethylpiperazin-1-yl)methanethione
CAS 678548-02-2C15H22N2OS
1-(3,4-Dichlorobenzothioyl)-4-ethylpiperazine chemical structure, C13H16Cl2N2S, CAS 677016-02-3
1-(3,4-Dichlorobenzothioyl)-4-ethylpiperazine
CAS 677016-02-3C13H16Cl2N2S
(4-Bromophenyl)-[4-(2-hydroxyethyl)piperazin-1-yl]methanethione chemical structure, C13H17BrN2OS, CAS 497865-46-0
(4-Bromophenyl)-[4-(2-hydroxyethyl)piperazin-1-yl]methanethione
CAS 497865-46-0C13H17BrN2OS
(4-Methylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanethione chemical structure, C15H22N2O3S, CAS 68209-01-8
(4-Methylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanethione
CAS 68209-01-8C15H22N2O3S
4-[(4-Ethyl-1-piperazinyl)carbonothioyl]phenol chemical structure, C13H18N2OS, CAS 488811-90-1
4-[(4-Ethyl-1-piperazinyl)carbonothioyl]phenol
CAS 488811-90-1C13H18N2OS
1-(4-Fluorobenzenecarbothioyl)-4-methylpiperazine chemical structure, C12H15FN2S, CAS 706777-62-0
1-(4-Fluorobenzenecarbothioyl)-4-methylpiperazine
CAS 706777-62-0C12H15FN2S
(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanethione chemical structure, C12H15N3O2S, CAS 708250-06-0
(4-Methylpiperazin-1-yl)(4-nitrophenyl)methanethione
CAS 708250-06-0C12H15N3O2S
(4-Methylpiperazin-1-yl)-(4-methylsulfanylphenyl)methanethione chemical structure, C13H18N2S2, CAS 712344-75-7
(4-Methylpiperazin-1-yl)-(4-methylsulfanylphenyl)methanethione
CAS 712344-75-7C13H18N2S2
(4-(Dipropylamino)phenyl)(piperazin-1-yl)methanethione chemical structure, C17H27N3S, CAS 867136-03-6
(4-(Dipropylamino)phenyl)(piperazin-1-yl)methanethione
CAS 867136-03-6C17H27N3S
4-[4-(Dimethylamino)benzenecarbothioyl]piperazine-1-carbothioamide chemical structure, C14H20N4S2, CAS 867136-05-8
4-[4-(Dimethylamino)benzenecarbothioyl]piperazine-1-carbothioamide
CAS 867136-05-8C14H20N4S2
2,2,2-Trichloro-1-[4-(4-methoxybenzenecarbothioyl)piperazin-1-yl]ethanone chemical structure, C14H15Cl3N2O2S, CAS 867136-06-9
2,2,2-Trichloro-1-[4-(4-methoxybenzenecarbothioyl)piperazin-1-yl]ethanone
CAS 867136-06-9C14H15Cl3N2O2S
2,2,2-Trichloro-1-[4-[4-(dimethylamino)benzenecarbothioyl]piperazin-1-yl]ethanone chemical structure, C15H18Cl3N3OS, CAS 867136-08-1
2,2,2-Trichloro-1-[4-[4-(dimethylamino)benzenecarbothioyl]piperazin-1-yl]ethanone
CAS 867136-08-1C15H18Cl3N3OS
(4-(Butylsulfonyl)piperazin-1-yl)(4-(dimethylamino)phenyl)methanethione chemical structure, C17H27N3O2S2, CAS 868153-19-9
(4-(Butylsulfonyl)piperazin-1-yl)(4-(dimethylamino)phenyl)methanethione
CAS 868153-19-9C17H27N3O2S2
1-(4-(4-Chlorophenylcarbonothioyl)piperazin-1-yl)ethanone chemical structure, C13H15ClN2OS, CAS 459198-24-4
1-(4-(4-Chlorophenylcarbonothioyl)piperazin-1-yl)ethanone
CAS 459198-24-4C13H15ClN2OS
Piperazine, 1-(3,4,5-trimethoxythiobenzoyl)-, hydrochloride chemical structure, C14H21ClN2O3S, CAS 70733-78-7
Piperazine, 1-(3,4,5-trimethoxythiobenzoyl)-, hydrochloride
CAS 70733-78-7C14H21ClN2O3S
Piperazine, 1-[thioxo(3,4,5-trimethoxyphenyl)methyl]- chemical structure, C14H20N2O3S, CAS 119049-32-0
Piperazine, 1-[thioxo(3,4,5-trimethoxyphenyl)methyl]-
CAS 119049-32-0C14H20N2O3S