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Murcko scaffold

Ring system with 4 rings and 23 atoms

20 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
20
With full pages
5
Scaffold SMILES

O=c1ccc(-c2nc3ccccc3n2Cc2ccccc2)c[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccc(-c2nc3ccccc3n2Cc2ccccc2)c[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

5-(1-Benzyl-5,6-dichloro-1H-1,3-benzimidazol-2-yl)-2(1H)-pyridinone chemical structure, C19H13Cl2N3O, CAS 338774-00-8
5-(1-Benzyl-5,6-dichloro-1H-1,3-benzimidazol-2-yl)-2(1H)-pyridinone
CAS 338774-00-8C19H13Cl2N3O
5-{5,6-Dichloro-1-[3-(trifluoromethyl)benzyl]-1H-1,3-benzimidazol-2-yl}-2(1H)-pyridinone chemical structure, C20H12Cl2F3N3O, CAS 338774-01-9
5-{5,6-Dichloro-1-[3-(trifluoromethyl)benzyl]-1H-1,3-benzimidazol-2-yl}-2(1H)-pyridinone
CAS 338774-01-9C20H12Cl2F3N3O
5-[5,6-Dichloro-1-(2-methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C20H15Cl2N3O, CAS 338774-03-1
5-[5,6-Dichloro-1-(2-methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 338774-03-1C20H15Cl2N3O
5-[5,6-Dichloro-1-(2-chlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C19H12Cl3N3O, CAS 338774-04-2
5-[5,6-Dichloro-1-(2-chlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 338774-04-2C19H12Cl3N3O
5-(1-Benzyl-5,6-dimethyl-1H-1,3-benzimidazol-2-yl)-2(1H)-pyridinone chemical structure, C21H19N3O, CAS 860787-82-2
5-(1-Benzyl-5,6-dimethyl-1H-1,3-benzimidazol-2-yl)-2(1H)-pyridinone
CAS 860787-82-2C21H19N3O
5-{5,6-Dimethyl-1-[4-(trifluoromethyl)benzyl]-1H-1,3-benzimidazol-2-yl}-2(1H)-pyridinone chemical structure, C22H18F3N3O, CAS 860787-83-3
5-{5,6-Dimethyl-1-[4-(trifluoromethyl)benzyl]-1H-1,3-benzimidazol-2-yl}-2(1H)-pyridinone
CAS 860787-83-3C22H18F3N3O
5-(1-Benzyl-5-chloro-1H-1,3-benzimidazol-2-yl)-2(1H)-pyridinone chemical structure, C19H14ClN3O, CAS 400075-96-9
5-(1-Benzyl-5-chloro-1H-1,3-benzimidazol-2-yl)-2(1H)-pyridinone
CAS 400075-96-9C19H14ClN3O
5-[1-(2-Chlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C19H14ClN3O, CAS 400077-24-9
5-[1-(2-Chlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 400077-24-9C19H14ClN3O
5-[1-(4-Chlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C19H14ClN3O, CAS 400077-26-1
5-[1-(4-Chlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 400077-26-1C19H14ClN3O
5-[1-(2,4-Dichlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C19H13Cl2N3O, CAS 400077-27-2
5-[1-(2,4-Dichlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 400077-27-2C19H13Cl2N3O
5-[1-(4-Methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C20H17N3O, CAS 400077-28-3
5-[1-(4-Methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 400077-28-3C20H17N3O
5-[1-(2-Methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C20H17N3O, CAS 860784-66-3
5-[1-(2-Methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 860784-66-3C20H17N3O
5-[1-(4-Chlorobenzyl)-5,6-dimethyl-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C21H18ClN3O, CAS 400077-29-4
5-[1-(4-Chlorobenzyl)-5,6-dimethyl-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 400077-29-4C21H18ClN3O
5-[1-(3,4-Dichlorobenzyl)-5,6-dimethyl-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C21H17Cl2N3O, CAS 400077-30-7
5-[1-(3,4-Dichlorobenzyl)-5,6-dimethyl-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 400077-30-7C21H17Cl2N3O
5-[5,6-Dimethyl-1-(4-methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C22H21N3O, CAS 400077-31-8
5-[5,6-Dimethyl-1-(4-methylbenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 400077-31-8C22H21N3O
5-{1-[3-(Trifluoromethyl)benzyl]-1H-1,3-benzimidazol-2-yl}-2(1H)-pyridinone chemical structure, C20H14F3N3O, CAS 400077-32-9
5-{1-[3-(Trifluoromethyl)benzyl]-1H-1,3-benzimidazol-2-yl}-2(1H)-pyridinone
CAS 400077-32-9C20H14F3N3O
5-[5,6-Dichloro-1-(3,4-dichlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C19H11Cl4N3O, CAS 338773-96-9
5-[5,6-Dichloro-1-(3,4-dichlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 338773-96-9C19H11Cl4N3O
5-[5,6-Dichloro-1-(2,4-dichlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C19H11Cl4N3O, CAS 338773-97-0
5-[5,6-Dichloro-1-(2,4-dichlorobenzyl)-1H-1,3-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 338773-97-0C19H11Cl4N3O
1-Methyl-5-[1-(phenylmethyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone chemical structure, C20H17N3O, CAS 1660116-13-1
1-Methyl-5-[1-(phenylmethyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone
CAS 1660116-13-1C20H17N3O
1-Benzyl-2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-benzimidazole-6-carbonitrile chemical structure, C22H18N4O, CAS 1660116-56-2
1-Benzyl-2-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-benzimidazole-6-carbonitrile
CAS 1660116-56-2C22H18N4O