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Murcko scaffold

Ring system with 4 rings and 22 atoms

11 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
11
With full pages
4
Scaffold SMILES

c1ccc(Cc2c(-c3ccccc3)cc3ccccn23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Cc2c(-c3ccccc3)cc3ccccn23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

3-(2-Nitro-1-phenylethyl)-2-phenylindolizine chemical structure, C22H18N2O2, CAS 3672-35-3
3-(2-Nitro-1-phenylethyl)-2-phenylindolizine
CAS 3672-35-3C22H18N2O2
3-[2-Nitro-1-(3,4,5-trimethoxyphenyl)ethyl]-2-phenylindolizine chemical structure, C25H24N2O5, CAS 716375-05-2
3-[2-Nitro-1-(3,4,5-trimethoxyphenyl)ethyl]-2-phenylindolizine
CAS 716375-05-2C25H24N2O5
3-[1-(4-Chlorophenyl)-2-nitroethyl]-2-phenylindolizine chemical structure, C22H17ClN2O2, CAS 717127-45-2
3-[1-(4-Chlorophenyl)-2-nitroethyl]-2-phenylindolizine
CAS 717127-45-2C22H17ClN2O2
3-[1-(4-Fluorophenyl)-2-nitroethyl]-2-phenylindolizine chemical structure, C22H17FN2O2, CAS 717119-26-1
3-[1-(4-Fluorophenyl)-2-nitroethyl]-2-phenylindolizine
CAS 717119-26-1C22H17FN2O2
3-[1-(2,4-Dimethoxyphenyl)-2-nitroethyl]-2-phenylindolizine chemical structure, C24H22N2O4, CAS 717125-49-0
3-[1-(2,4-Dimethoxyphenyl)-2-nitroethyl]-2-phenylindolizine
CAS 717125-49-0C24H22N2O4
3-[1-(2,4-Dichlorophenyl)-2-nitroethyl]-2-phenylindolizine chemical structure, C22H16Cl2N2O2, CAS 717119-14-7
3-[1-(2,4-Dichlorophenyl)-2-nitroethyl]-2-phenylindolizine
CAS 717119-14-7C22H16Cl2N2O2
3-{2-Nitro-1-[4-(trifluoromethyl)phenyl]ethyl}-2-phenylindolizine chemical structure, C23H17F3N2O2, CAS 716375-37-0
3-{2-Nitro-1-[4-(trifluoromethyl)phenyl]ethyl}-2-phenylindolizine
CAS 716375-37-0C23H17F3N2O2
3-[1-(4-Methoxyphenyl)-2-nitroethyl]-2-phenylindolizine chemical structure, C23H20N2O3, CAS 716375-07-4
3-[1-(4-Methoxyphenyl)-2-nitroethyl]-2-phenylindolizine
CAS 716375-07-4C23H20N2O3
3-[1-(2-Chloro-6-fluorophenyl)-2-nitroethyl]-2-phenylindolizine chemical structure, C22H16ClFN2O2, CAS 716375-35-8
3-[1-(2-Chloro-6-fluorophenyl)-2-nitroethyl]-2-phenylindolizine
CAS 716375-35-8C22H16ClFN2O2
3-[1-(3,4-Dimethoxyphenyl)-2-nitroethyl]-2-phenylindolizine chemical structure, C24H22N2O4, CAS 716375-06-3
3-[1-(3,4-Dimethoxyphenyl)-2-nitroethyl]-2-phenylindolizine
CAS 716375-06-3C24H22N2O4
3-{1-[4-(Difluoromethoxy)phenyl]-2-nitroethyl}-2-phenylindolizine chemical structure, C23H18F2N2O3, CAS 716375-36-9
3-{1-[4-(Difluoromethoxy)phenyl]-2-nitroethyl}-2-phenylindolizine
CAS 716375-36-9C23H18F2N2O3