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Murcko scaffold

Ring system with 3 rings and 25 atoms

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
14
With full pages
3
Scaffold SMILES

O=C(CSCC(=O)N1CCNCC1)Nc1nc(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSCC(=O)N1CCNCC1)Nc1nc(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

Ethyl 4-(2-((2-((4-(4-methoxyphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C21H26N4O5S2, CAS 681223-63-2
Ethyl 4-(2-((2-((4-(4-methoxyphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681223-63-2C21H26N4O5S2
Ethyl 4-(2-((2-oxo-2-((4-phenylthiazol-2-yl)amino)ethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C20H24N4O4S2, CAS 681222-21-9
Ethyl 4-(2-((2-oxo-2-((4-phenylthiazol-2-yl)amino)ethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681222-21-9C20H24N4O4S2
Ethyl 4-(2-((2-((4-(4-ethylphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C22H28N4O4S2, CAS 681222-50-4
Ethyl 4-(2-((2-((4-(4-ethylphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681222-50-4C22H28N4O4S2
Ethyl 4-(2-((2-((4-(4-bromophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C20H23BrN4O4S2, CAS 681223-30-3
Ethyl 4-(2-((2-((4-(4-bromophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681223-30-3C20H23BrN4O4S2
Ethyl 4-{2-[({[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]carbamoyl}methyl)sulfanyl]acetyl}piperazine-1-carboxylate chemical structure, C22H28N4O4S2, CAS 681222-78-6
Ethyl 4-{2-[({[4-(2,4-dimethylphenyl)-1,3-thiazol-2-yl]carbamoyl}methyl)sulfanyl]acetyl}piperazine-1-carboxylate
CAS 681222-78-6C22H28N4O4S2
Ethyl 4-(2-((2-((4-(4-fluorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C20H23FN4O4S2, CAS 681222-95-7
Ethyl 4-(2-((2-((4-(4-fluorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681222-95-7C20H23FN4O4S2
Ethyl 4-(2-((2-((4-(4-chlorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C20H23ClN4O4S2, CAS 681223-16-5
Ethyl 4-(2-((2-((4-(4-chlorophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681223-16-5C20H23ClN4O4S2
Ethyl 4-(2-((2-((5-methyl-4-phenylthiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C21H26N4O4S2, CAS 681225-18-3
Ethyl 4-(2-((2-((5-methyl-4-phenylthiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681225-18-3C21H26N4O4S2
Ethyl 4-{2-[({[4-(4-ethoxyphenyl)-5-methyl-1,3-thiazol-2-yl]carbamoyl}methyl)sulfanyl]acetyl}piperazine-1-carboxylate chemical structure, C23H30N4O5S2, CAS 681225-49-0
Ethyl 4-{2-[({[4-(4-ethoxyphenyl)-5-methyl-1,3-thiazol-2-yl]carbamoyl}methyl)sulfanyl]acetyl}piperazine-1-carboxylate
CAS 681225-49-0C23H30N4O5S2
Ethyl 4-(2-((2-oxo-2-((4-(p-tolyl)thiazol-2-yl)amino)ethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C21H26N4O4S2, CAS 681222-35-5
Ethyl 4-(2-((2-oxo-2-((4-(p-tolyl)thiazol-2-yl)amino)ethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681222-35-5C21H26N4O4S2
Ethyl 4-(2-((2-((4-(4-methoxyphenyl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C22H28N4O5S2, CAS 681225-33-2
Ethyl 4-(2-((2-((4-(4-methoxyphenyl)-5-methylthiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681225-33-2C22H28N4O5S2
Ethyl 4-(2-((2-((4-(4-isopropylphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C23H30N4O4S2, CAS 681223-93-8
Ethyl 4-(2-((2-((4-(4-isopropylphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681223-93-8C23H30N4O4S2
Ethyl 4-(2-((2-((4-(3,4-dimethylphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C22H28N4O4S2, CAS 681222-64-0
Ethyl 4-(2-((2-((4-(3,4-dimethylphenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681222-64-0C22H28N4O4S2
Ethyl 4-(2-((2-((4-(4-iodophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate chemical structure, C20H23IN4O4S2, CAS 681223-48-3
Ethyl 4-(2-((2-((4-(4-iodophenyl)thiazol-2-yl)amino)-2-oxoethyl)thio)acetyl)piperazine-1-carboxylate
CAS 681223-48-3C20H23IN4O4S2