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Murcko scaffold

Ring system with 3 rings and 24 atoms

184 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 24
Chemicals: 184
With full pages: 75

Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)[nH]1)NN=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)NN=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 184 chemicals

2-((4-Ethyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-fluorobenzylidene)acetohydrazide chemical structure, C19H18FN5OS, CAS 361165-48-2

2-((4-Ethyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-fluorobenzylidene)acetohydrazide

CAS 361165-48-2C₁₉H₁₈FN₅OS

2-[[5-(4-Chlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]thio]acetic acid 2-[(2,5-dimethoxyphenyl)methylene]hydrazide chemical structure, C21H22ClN5O3S, CAS 488122-77-6

2-[[5-(4-Chlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl]thio]acetic acid 2-[(2,5-dimethoxyphenyl)methylene]hydrazide

CAS 488122-77-6C₂₁H₂₂ClN₅O₃S

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3,4-dimethoxybenzylidene)acetohydrazide chemical structure, C25H31N5O3S, CAS 497170-19-1

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3,4-dimethoxybenzylidene)acetohydrazide

CAS 497170-19-1C₂₅H₃₁N₅O₃S

N'-Benzylidene-2-((5-(3,4-dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide chemical structure, C21H23N5O3S, CAS 488839-89-0

N'-Benzylidene-2-((5-(3,4-dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

CAS 488839-89-0C₂₁H₂₃N₅O₃S

2-((5-(3,4-Dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-hydroxybenzylidene)acetohydrazide chemical structure, C21H23N5O4S, CAS 488134-07-2

2-((5-(3,4-Dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-hydroxybenzylidene)acetohydrazide

CAS 488134-07-2C₂₁H₂₃N₅O₄S

2-((5-(3,4-Dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide chemical structure, C22H25N5O4S, CAS 488858-68-0

2-((5-(3,4-Dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide

CAS 488858-68-0C₂₂H₂₅N₅O₄S

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide chemical structure, C24H29N5O2S, CAS 497170-01-1

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide

CAS 497170-01-1C₂₄H₂₉N₅O₂S

2-((5-(4-Chlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3,4-dichlorobenzylidene)acetohydrazide chemical structure, C19H16Cl3N5OS, CAS 487032-82-6

2-((5-(4-Chlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3,4-dichlorobenzylidene)acetohydrazide

CAS 487032-82-6C₁₉H₁₆Cl₃N₅OS

2-((5-(3,4-Dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-nitrobenzylidene)acetohydrazide chemical structure, C21H22N6O5S, CAS 488132-30-5

2-((5-(3,4-Dimethoxyphenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-nitrobenzylidene)acetohydrazide

CAS 488132-30-5C₂₁H₂₂N₆O₅S

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-ethoxybenzylidene)acetohydrazide chemical structure, C25H31N5O2S, CAS 489442-79-7

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-ethoxybenzylidene)acetohydrazide

CAS 489442-79-7C₂₅H₃₁N₅O₂S

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-(methylthio)benzylidene)acetohydrazide chemical structure, C24H29N5OS2, CAS 487029-93-6

2-((5-(4-(tert-Butyl)phenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-(methylthio)benzylidene)acetohydrazide

CAS 487029-93-6C₂₄H₂₉N₅OS₂

2-[[5-(3-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio]acetic acid 2-[(4-fluorophenyl)methylene]hydrazide chemical structure, C18H15ClFN5OS, CAS 347910-20-7

2-[[5-(3-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio]acetic acid 2-[(4-fluorophenyl)methylene]hydrazide

CAS 347910-20-7C₁₈H₁₅ClFN₅OS

2-((4-Ethyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-fluorobenzylidene)acetohydrazide chemical structure, C19H18FN5OS, CAS 361165-00-6

2-((4-Ethyl-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-fluorobenzylidene)acetohydrazide

CAS 361165-00-6C₁₉H₁₈FN₅OS

2-((5-(3-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4-dichlorobenzylidene)acetohydrazide chemical structure, C18H14Cl3N5OS, CAS 348592-03-0

2-((5-(3-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2,4-dichlorobenzylidene)acetohydrazide

CAS 348592-03-0C₁₈H₁₄Cl₃N₅OS

2-((5-(4-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-hydroxy-3-methoxybenzylidene)acetohydrazide chemical structure, C19H18BrN5O3S, CAS 347906-44-9

2-((5-(4-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-hydroxy-3-methoxybenzylidene)acetohydrazide

CAS 347906-44-9C₁₉H₁₈BrN₅O₃S

2-((5-(4-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-(dimethylamino)benzylidene)acetohydrazide chemical structure, C20H21ClN6OS, CAS 347912-35-0

2-((5-(4-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-(dimethylamino)benzylidene)acetohydrazide

CAS 347912-35-0C₂₀H₂₁ClN₆OS

2-[[5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio]acetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide chemical structure, C21H20BrN5O2S, CAS 347907-35-1

2-[[5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio]acetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

CAS 347907-35-1C₂₁H₂₀BrN₅O₂S

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-isopropylbenzylidene)acetohydrazide chemical structure, C21H22BrN5OS, CAS 347912-28-1

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-isopropylbenzylidene)acetohydrazide

CAS 347912-28-1C₂₁H₂₂BrN₅OS

N'-(4-Bromobenzylidene)-2-((5-(3-bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide chemical structure, C18H15Br2N5OS, CAS 348100-02-7

N'-(4-Bromobenzylidene)-2-((5-(3-bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

CAS 348100-02-7C₁₈H₁₅Br₂N₅OS

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-methoxybenzylidene)acetohydrazide chemical structure, C19H18BrN5O2S, CAS 348100-48-1

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(4-methoxybenzylidene)acetohydrazide

CAS 348100-48-1C₁₉H₁₈BrN₅O₂S

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide chemical structure, C19H18BrN5O2S, CAS 348100-81-2

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide

CAS 348100-81-2C₁₉H₁₈BrN₅O₂S

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-chlorobenzylidene)acetohydrazide chemical structure, C18H15BrClN5OS, CAS 348593-08-8

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-chlorobenzylidene)acetohydrazide

CAS 348593-08-8C₁₈H₁₅BrClN₅OS

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-hydroxy-3-methoxybenzylidene)acetohydrazide chemical structure, C19H18BrN5O3S, CAS 348587-22-4

2-((5-(3-Bromophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)-N'-(2-hydroxy-3-methoxybenzylidene)acetohydrazide

CAS 348587-22-4C₁₉H₁₈BrN₅O₃S

2-((5-(4-Chlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide chemical structure, C20H20ClN5O2S, CAS 488086-70-0

2-((5-(4-Chlorophenyl)-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N'-(3-methoxybenzylidene)acetohydrazide

CAS 488086-70-0C₂₀H₂₀ClN₅O₂S