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Murcko scaffold

2-Phenylpyrrolidin-3-one scaffold

18 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
18
With full pages
4
Scaffold SMILES

O=C1CCNC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenylpyrrolidin-3-one page
Murcko scaffold O=C1CCNC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

Methyl 2-(4-methoxyphenyl)-3-oxo-1-pyrrolidinecarboxylate chemical structure, C13H15NO4, CAS 801282-29-1
Methyl 2-(4-methoxyphenyl)-3-oxo-1-pyrrolidinecarboxylate
CAS 801282-29-1C13H15NO4
tert-Butyl 3-oxo-2-phenylpyrrolidine-1-carboxylate chemical structure, C15H19NO3, CAS 801282-28-0
tert-Butyl 3-oxo-2-phenylpyrrolidine-1-carboxylate
CAS 801282-28-0C15H19NO3
3-Pyrrolidinone, 1-methyl-2-phenyl- chemical structure, C11H13NO, CAS 105906-98-7
3-Pyrrolidinone, 1-methyl-2-phenyl-
CAS 105906-98-7C11H13NO
2-Phenylpyrrolidin-3-one chemical structure, C10H11NO, CAS 1369106-27-3
2-Phenylpyrrolidin-3-one
CAS 1369106-27-3C10H11NO
2-Methyl-2-phenylpyrrolidin-3-one chemical structure, C11H13NO, CAS 1505297-13-1
2-Methyl-2-phenylpyrrolidin-3-one
CAS 1505297-13-1C11H13NO
2-(3-Methylphenyl)pyrrolidin-3-one chemical structure, C11H13NO, CAS 1555895-35-6
2-(3-Methylphenyl)pyrrolidin-3-one
CAS 1555895-35-6C11H13NO
2-(2-Methylphenyl)pyrrolidin-3-one chemical structure, C11H13NO, CAS 1553957-69-9
2-(2-Methylphenyl)pyrrolidin-3-one
CAS 1553957-69-9C11H13NO
2-(4-Methylphenyl)pyrrolidin-3-one chemical structure, C11H13NO, CAS 1545135-61-2
2-(4-Methylphenyl)pyrrolidin-3-one
CAS 1545135-61-2C11H13NO
2-(3,5-Dimethylphenyl)pyrrolidin-3-one chemical structure, C12H15NO, CAS 1547058-16-1
2-(3,5-Dimethylphenyl)pyrrolidin-3-one
CAS 1547058-16-1C12H15NO
2-(2-Methoxyphenyl)pyrrolidin-3-one chemical structure, C11H13NO2, CAS 1552534-51-6
2-(2-Methoxyphenyl)pyrrolidin-3-one
CAS 1552534-51-6C11H13NO2
2-(2,5-Difluorophenyl)pyrrolidin-3-one chemical structure, C10H9F2NO, CAS 1547059-63-1
2-(2,5-Difluorophenyl)pyrrolidin-3-one
CAS 1547059-63-1C10H9F2NO
2-(3-Bromophenyl)pyrrolidin-3-one chemical structure, C10H10BrNO, CAS 1781859-86-6
2-(3-Bromophenyl)pyrrolidin-3-one
CAS 1781859-86-6C10H10BrNO
2-(4-Bromophenyl)pyrrolidin-3-one chemical structure, C10H10BrNO, CAS 1782762-55-3
2-(4-Bromophenyl)pyrrolidin-3-one
CAS 1782762-55-3C10H10BrNO
2-Phenylpyrrolidin-3-one hydrochloride chemical structure, C10H12ClNO, CAS 1783972-17-7
2-Phenylpyrrolidin-3-one hydrochloride
CAS 1783972-17-7C10H12ClNO
3-Pyrrolidinone, 2-methyl-2-(4-methylphenyl)-, hydrochloride (1:1) chemical structure, C12H16ClNO, CAS 1892592-57-2
3-Pyrrolidinone, 2-methyl-2-(4-methylphenyl)-, hydrochloride (1:1)
CAS 1892592-57-2C12H16ClNO
tert-Butyl 2-(3-bromophenyl)-3-oxopyrrolidine-1-carboxylate chemical structure, C15H18BrNO3, CAS 2358049-59-7
tert-Butyl 2-(3-bromophenyl)-3-oxopyrrolidine-1-carboxylate
CAS 2358049-59-7C15H18BrNO3
2-[4-(Trifluoromethyl)phenyl]pyrrolidin-3-one chemical structure, C11H10F3NO, CAS 2138209-28-4
2-[4-(Trifluoromethyl)phenyl]pyrrolidin-3-one
CAS 2138209-28-4C11H10F3NO
2-Phenyl-1-(prop-2-enoyl)pyrrolidin-3-one chemical structure, C13H13NO2, CAS 2694734-53-5
2-Phenyl-1-(prop-2-enoyl)pyrrolidin-3-one
CAS 2694734-53-5C13H13NO2