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Murcko scaffold

1-(Naphthalene-2-carbonyl)piperazine scaffold

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
26
With full pages
3
Scaffold SMILES

O=C(c1ccc2ccccc2c1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Naphthalene-2-carbonyl)piperazine page
Murcko scaffold O=C(c1ccc2ccccc2c1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

(3-Methoxynaphthalen-2-yl)(4-methylpiperazin-1-yl)methanone chemical structure, C17H20N2O2, CAS 425649-65-6
(3-Methoxynaphthalen-2-yl)(4-methylpiperazin-1-yl)methanone
CAS 425649-65-6C17H20N2O2
3-[(4-Methylpiperazin-1-yl)carbonyl]-2-naphthol chemical structure, C16H18N2O2, CAS 16236-13-8
3-[(4-Methylpiperazin-1-yl)carbonyl]-2-naphthol
CAS 16236-13-8C16H18N2O2
4-(Naphthalen-2-ylcarbonyl)piperazine-1-carbaldehyde chemical structure, C16H16N2O2, CAS 429626-25-5
4-(Naphthalen-2-ylcarbonyl)piperazine-1-carbaldehyde
CAS 429626-25-5C16H16N2O2
4-(Naphthalene-2-carbonyl)-piperazine-1-carboxylic acid ethyl ester chemical structure, C18H20N2O3, CAS 429629-04-9
4-(Naphthalene-2-carbonyl)-piperazine-1-carboxylic acid ethyl ester
CAS 429629-04-9C18H20N2O3
1-(Naphthalene-2-carbonyl)piperazine chemical structure, C15H16N2O, CAS 610802-12-5
1-(Naphthalene-2-carbonyl)piperazine
CAS 610802-12-5C15H16N2O
1-[4-(3-Methoxynaphthalene-2-carbonyl)piperazin-1-yl]ethan-1-one chemical structure, C18H20N2O3, CAS 1017339-63-7
1-[4-(3-Methoxynaphthalene-2-carbonyl)piperazin-1-yl]ethan-1-one
CAS 1017339-63-7C18H20N2O3
[4-(2-Aminoethyl)-1-piperazinyl]-2-naphthalenylmethanone chemical structure, C17H21N3O, CAS 1094880-42-8
[4-(2-Aminoethyl)-1-piperazinyl]-2-naphthalenylmethanone
CAS 1094880-42-8C17H21N3O
1-(Naphthalene-2-carbonyl)piperazine hydrochloride chemical structure, C15H17ClN2O, CAS 1093630-38-6
1-(Naphthalene-2-carbonyl)piperazine hydrochloride
CAS 1093630-38-6C15H17ClN2O
1-((7-Bromo-3-hydroxy-2-naphthyl)carbonyl)-4-methylpiperazinium chloride chemical structure, C16H18BrClN2O2, CAS 94333-53-6
1-((7-Bromo-3-hydroxy-2-naphthyl)carbonyl)-4-methylpiperazinium chloride
CAS 94333-53-6C16H18BrClN2O2
1-(Naphthalene-2-carbonyl)-4-(2,2,2-trifluoroethyl)piperazine chemical structure, C17H17F3N2O, CAS 1331352-26-1
1-(Naphthalene-2-carbonyl)-4-(2,2,2-trifluoroethyl)piperazine
CAS 1331352-26-1C17H17F3N2O
3-Methyl-1-(naphthalene-2-carbonyl)piperazine chemical structure, C16H18N2O, CAS 1240581-48-9
3-Methyl-1-(naphthalene-2-carbonyl)piperazine
CAS 1240581-48-9C16H18N2O
6-(Piperazin-1-ylcarbonyl)-2-naphthol chemical structure, C15H16N2O2, CAS 1287217-64-4
6-(Piperazin-1-ylcarbonyl)-2-naphthol
CAS 1287217-64-4C15H16N2O2
(6-Bromonaphthalen-2-yl)-(4-methylpiperazin-1-yl)methanone chemical structure, C16H17BrN2O, CAS 1007213-43-5
(6-Bromonaphthalen-2-yl)-(4-methylpiperazin-1-yl)methanone
CAS 1007213-43-5C16H17BrN2O
2-Methyl-1-(naphthalene-2-carbonyl)piperazine chemical structure, C16H18N2O, CAS 1240566-58-8
2-Methyl-1-(naphthalene-2-carbonyl)piperazine
CAS 1240566-58-8C16H18N2O
2-Chloro-1-[4-(naphthalene-2-carbonyl)piperazin-1-yl]propan-1-one chemical structure, C18H19ClN2O2, CAS 2411255-61-1
2-Chloro-1-[4-(naphthalene-2-carbonyl)piperazin-1-yl]propan-1-one
CAS 2411255-61-1C18H19ClN2O2
(5-Bromonaphthalen-2-yl)(4-methylpiperazin-1-yl)methanone chemical structure, C16H17BrN2O, CAS 3078452-36-2
(5-Bromonaphthalen-2-yl)(4-methylpiperazin-1-yl)methanone
CAS 3078452-36-2C16H17BrN2O
(5-Bromonaphthalen-2-yl)(4-ethylpiperazin-1-yl)methanone chemical structure, C17H19BrN2O, CAS 3078520-67-6
(5-Bromonaphthalen-2-yl)(4-ethylpiperazin-1-yl)methanone
CAS 3078520-67-6C17H19BrN2O
(5-Bromonaphthalen-2-yl)(4-isopropylpiperazin-1-yl)methanone chemical structure, C18H21BrN2O, CAS 3078566-96-5
(5-Bromonaphthalen-2-yl)(4-isopropylpiperazin-1-yl)methanone
CAS 3078566-96-5C18H21BrN2O
(5-Bromonaphthalen-2-yl)(4-(2,2,2-trifluoroethyl)piperazin-1-yl)methanone chemical structure, C17H16BrF3N2O, CAS 3078558-75-2
(5-Bromonaphthalen-2-yl)(4-(2,2,2-trifluoroethyl)piperazin-1-yl)methanone
CAS 3078558-75-2C17H16BrF3N2O
(5-Bromonaphthalen-2-yl)(piperazin-1-yl)methanone chemical structure, C15H15BrN2O, CAS 3078474-17-3
(5-Bromonaphthalen-2-yl)(piperazin-1-yl)methanone
CAS 3078474-17-3C15H15BrN2O
tert-Butyl 4-(5-bromo-2-naphthoyl)piperazine-1-carboxylate chemical structure, C20H23BrN2O3, CAS 3078560-57-0
tert-Butyl 4-(5-bromo-2-naphthoyl)piperazine-1-carboxylate
CAS 3078560-57-0C20H23BrN2O3
tert-Butyl 4-(5-bromo-2-naphthoyl)-2-methylpiperazine-1-carboxylate chemical structure, C21H25BrN2O3, CAS 3078567-04-8
tert-Butyl 4-(5-bromo-2-naphthoyl)-2-methylpiperazine-1-carboxylate
CAS 3078567-04-8C21H25BrN2O3
tert-Butyl 4-(5-bromo-2-naphthoyl)-3-methylpiperazine-1-carboxylate chemical structure, C21H25BrN2O3, CAS 3078557-72-6
tert-Butyl 4-(5-bromo-2-naphthoyl)-3-methylpiperazine-1-carboxylate
CAS 3078557-72-6C21H25BrN2O3
tert-Butyl 4-(5-vinyl-2-naphthoyl)piperazine-1-carboxylate chemical structure, C22H26N2O3, CAS 3078580-13-6
tert-Butyl 4-(5-vinyl-2-naphthoyl)piperazine-1-carboxylate
CAS 3078580-13-6C22H26N2O3