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Murcko scaffold

Ring system with 2 rings and 13 atoms

47 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
47
With full pages
6
Scaffold SMILES

O=C1N=CSC1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N=CSC1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 47 of 47 chemicals

N-[(5E)-5-[(2-Methylphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C13H12N2O2S, CAS 5961-39-7
N-[(5E)-5-[(2-Methylphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 5961-39-7C13H12N2O2S
5-(3-Fluoro-benzylidene)-2-imino-thiazolidin-4-one chemical structure, C10H7FN2OS, CAS 332897-44-6
5-(3-Fluoro-benzylidene)-2-imino-thiazolidin-4-one
CAS 332897-44-6C10H7FN2OS
Mirin chemical structure, C10H8N2O2S, CAS 299953-00-7
Mirin
CAS 299953-00-7C10H8N2O2S
(5Z)-5-(2-Chloro-6-fluorobenzylidene)-2-imino-2,5-dihydro-1,3-thiazol-4-ol chemical structure, C10H6ClFN2OS, CAS 302551-38-8
(5Z)-5-(2-Chloro-6-fluorobenzylidene)-2-imino-2,5-dihydro-1,3-thiazol-4-ol
CAS 302551-38-8C10H6ClFN2OS
(5Z)-2-Amino-5-[(4-bromo-3-nitrophenyl)methylidene]-1,3-thiazol-4-one chemical structure, C10H6BrN3O3S, CAS 331660-12-9
(5Z)-2-Amino-5-[(4-bromo-3-nitrophenyl)methylidene]-1,3-thiazol-4-one
CAS 331660-12-9C10H6BrN3O3S
N-[5-(2-Ethoxybenzylidene)-4-oxo-1,3-thiazolidin-2-ylidene]acetamide chemical structure, C14H14N2O3S, CAS 5963-69-9
N-[5-(2-Ethoxybenzylidene)-4-oxo-1,3-thiazolidin-2-ylidene]acetamide
CAS 5963-69-9C14H14N2O3S
(5Z)-2-Amino-5-[(3-chloro-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one chemical structure, C10H7ClN2O2S, CAS 354777-48-3
(5Z)-2-Amino-5-[(3-chloro-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one
CAS 354777-48-3C10H7ClN2O2S
N-[(5Z)-5-[(4-Ethoxy-3-iodo-5-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C15H15IN2O4S, CAS 359421-21-9
N-[(5Z)-5-[(4-Ethoxy-3-iodo-5-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 359421-21-9C15H15IN2O4S
N-[(5Z)-5-[(3-Chloro-4-ethoxy-5-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C15H15ClN2O4S, CAS 449774-01-0
N-[(5Z)-5-[(3-Chloro-4-ethoxy-5-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 449774-01-0C15H15ClN2O4S
RefChem:382173 chemical structure, C12H12N2O3S, CAS 5573-59-1
RefChem:382173
CAS 5573-59-1C12H12N2O3S
(Z)-2-Amino-5-(4-chlorobenzylidene)thiazol-4(5H)-one chemical structure, C10H7ClN2OS, CAS 76988-00-6
(Z)-2-Amino-5-(4-chlorobenzylidene)thiazol-4(5H)-one
CAS 76988-00-6C10H7ClN2OS
RefChem:382256 chemical structure, C12H11ClN2O3S, CAS 6378-08-1
RefChem:382256
CAS 6378-08-1C12H11ClN2O3S
(5Z)-2-Amino-5-[(3-bromo-4-fluorophenyl)methylidene]-1,3-thiazol-4-one chemical structure, C10H6BrFN2OS, CAS 354557-99-6
(5Z)-2-Amino-5-[(3-bromo-4-fluorophenyl)methylidene]-1,3-thiazol-4-one
CAS 354557-99-6C10H6BrFN2OS
Benzoicacid,4-[(2-amino-4-oxo-5(4H)-thiazolylidene)methyl]- chemical structure, C11H8N2O3S
Benzoicacid,4-[(2-amino-4-oxo-5(4H)-thiazolylidene)methyl]-
C11H8N2O3S
4-[(Z)-(2-Amino-4-oxo-1,3-thiazol-5(4H)-ylidene)methyl]benzoic acid chemical structure, C11H8N2O3S, CAS 1972664-01-9
4-[(Z)-(2-Amino-4-oxo-1,3-thiazol-5(4H)-ylidene)methyl]benzoic acid
CAS 1972664-01-9C11H8N2O3S
N-[(5Z)-5-[(3-Ethoxy-4-prop-2-enoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C17H18N2O4S, CAS 446038-49-9
N-[(5Z)-5-[(3-Ethoxy-4-prop-2-enoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 446038-49-9C17H18N2O4S
N-[(5Z)-5-[(5-Chloro-2-prop-2-enoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C15H13ClN2O3S, CAS 529500-93-4
N-[(5Z)-5-[(5-Chloro-2-prop-2-enoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 529500-93-4C15H13ClN2O3S
N-[(5Z)-5-[(3-Bromo-4-hydroxy-5-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C13H11BrN2O4S, CAS 358988-47-3
N-[(5Z)-5-[(3-Bromo-4-hydroxy-5-methoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 358988-47-3C13H11BrN2O4S
N-[(5Z)-5-[(5-Bromo-2-ethoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C14H13BrN2O3S, CAS 358387-59-4
N-[(5Z)-5-[(5-Bromo-2-ethoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 358387-59-4C14H13BrN2O3S
N-[(5Z)-5-[(3-Chloro-5-ethoxy-4-prop-2-ynoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C17H15ClN2O4S, CAS 471889-95-9
N-[(5Z)-5-[(3-Chloro-5-ethoxy-4-prop-2-ynoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 471889-95-9C17H15ClN2O4S
N-[(5Z)-5-[(3-Iodo-5-methoxy-4-prop-2-ynoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C16H13IN2O4S, CAS 471889-92-6
N-[(5Z)-5-[(3-Iodo-5-methoxy-4-prop-2-ynoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 471889-92-6C16H13IN2O4S
N-[(5Z)-5-[(3-Bromo-5-methoxy-4-prop-2-ynoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C16H13BrN2O4S, CAS 535976-27-3
N-[(5Z)-5-[(3-Bromo-5-methoxy-4-prop-2-ynoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 535976-27-3C16H13BrN2O4S
N-[(5Z)-5-[(5-Chloro-2-propoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C15H15ClN2O3S, CAS 532949-56-7
N-[(5Z)-5-[(5-Chloro-2-propoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 532949-56-7C15H15ClN2O3S
N-[(5Z)-5-[(3-Bromo-5-ethoxy-4-prop-2-enoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide chemical structure, C17H17BrN2O4S, CAS 530140-18-2
N-[(5Z)-5-[(3-Bromo-5-ethoxy-4-prop-2-enoxyphenyl)methylidene]-4-oxo-1,3-thiazol-2-yl]acetamide
CAS 530140-18-2C17H17BrN2O4S