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Murcko scaffold

Ring system with 3 rings and 20 atoms

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
11
With full pages
4
Scaffold SMILES

O=C(Nc1ccccc1N1CCNCC1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1N1CCNCC1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

N-{2-[4-(Methylsulfonyl)piperazino]phenyl}-2-thiophenecarboxamide chemical structure, C16H19N3O3S2, CAS 478260-33-2
N-{2-[4-(Methylsulfonyl)piperazino]phenyl}-2-thiophenecarboxamide
CAS 478260-33-2C16H19N3O3S2
N-[2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide chemical structure, C17H18F3N3OS, CAS 514199-68-9
N-[2-(4-Methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]thiophene-2-carboxamide
CAS 514199-68-9C17H18F3N3OS
N-[2-(4-Methylpiperazin-1-yl)phenyl]thiophene-2-carboxamide chemical structure, C16H19N3OS, CAS 824980-33-8
N-[2-(4-Methylpiperazin-1-yl)phenyl]thiophene-2-carboxamide
CAS 824980-33-8C16H19N3OS
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]thiophene-2-carboxamide chemical structure, C18H20ClN3O2S, CAS 717864-07-8
N-[5-Chloro-2-(4-propanoylpiperazin-1-yl)phenyl]thiophene-2-carboxamide
CAS 717864-07-8C18H20ClN3O2S
N-[2-[4-(2-Methylpropanoyl)piperazin-1-yl]phenyl]thiophene-2-carboxamide chemical structure, C19H23N3O2S, CAS 761418-34-2
N-[2-[4-(2-Methylpropanoyl)piperazin-1-yl]phenyl]thiophene-2-carboxamide
CAS 761418-34-2C19H23N3O2S
N-[2-(4-Acetylpiperazin-1-yl)phenyl]thiophene-2-carboxamide chemical structure, C17H19N3O2S, CAS 839689-48-4
N-[2-(4-Acetylpiperazin-1-yl)phenyl]thiophene-2-carboxamide
CAS 839689-48-4C17H19N3O2S
Methyl 4-(4-methylpiperazin-1-yl)-3-(thiophene-2-carbonylamino)benzoate chemical structure, C18H21N3O3S, CAS 876889-47-3
Methyl 4-(4-methylpiperazin-1-yl)-3-(thiophene-2-carbonylamino)benzoate
CAS 876889-47-3C18H21N3O3S
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-2-thiophenecarboxamide chemical structure, C19H22ClN3O2S, CAS 895344-91-9
N-[5-Chloro-2-(4-isobutyryl-1-piperazinyl)phenyl]-2-thiophenecarboxamide
CAS 895344-91-9C19H22ClN3O2S
N-[2-(4-Butanoylpiperazin-1-yl)-5-chlorophenyl]thiophene-2-carboxamide chemical structure, C19H22ClN3O2S, CAS 899125-36-1
N-[2-(4-Butanoylpiperazin-1-yl)-5-chlorophenyl]thiophene-2-carboxamide
CAS 899125-36-1C19H22ClN3O2S
N-[3-Chloro-2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]thiophene-2-carboxamide chemical structure, C19H22ClN3O2S, CAS 916035-52-4
N-[3-Chloro-2-[4-(2-methylpropanoyl)piperazin-1-yl]phenyl]thiophene-2-carboxamide
CAS 916035-52-4C19H22ClN3O2S
N-[3-Chloro-2-(4-methylpiperazin-1-yl)phenyl]thiophene-2-carboxamide chemical structure, C16H18ClN3OS, CAS 1003434-88-5
N-[3-Chloro-2-(4-methylpiperazin-1-yl)phenyl]thiophene-2-carboxamide
CAS 1003434-88-5C16H18ClN3OS