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Murcko scaffold

(3,4-Dihydroisoquinolin-2(1H)-yl)(piperidin-4-yl)methanone scaffold

17 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 18
Chemicals: 17
With full pages: 3

Scaffold SMILES

O=C(C1CCNCC1)N1CCc2ccccc2C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the (3,4-Dihydroisoquinolin-2(1H)-yl)(piperidin-4-yl)methanone page

Murcko scaffold O=C(C1CCNCC1)N1CCc2ccccc2C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

(3,4-Dihydroisoquinolin-2(1H)-yl)(piperidin-4-yl)methanone chemical structure, C15H20N2O, CAS 120848-76-2

(3,4-Dihydroisoquinolin-2(1H)-yl)(piperidin-4-yl)methanone

CAS 120848-76-2C₁₅H₂₀N₂O

3,4-Dihydro-1H-isoquinolin-2-yl-(1-methylsulfonylpiperidin-4-yl)methanone chemical structure, C16H22N2O3S, CAS 664312-87-2

3,4-Dihydro-1H-isoquinolin-2-yl-(1-methylsulfonylpiperidin-4-yl)methanone

CAS 664312-87-2C₁₆H₂₂N₂O₃S

3,4-Dihydro-1H-isoquinolin-2-yl-(1-ethylsulfonyl-4-piperidinyl)methanone chemical structure, C17H24N2O3S, CAS 705959-83-7

3,4-Dihydro-1H-isoquinolin-2-yl-(1-ethylsulfonyl-4-piperidinyl)methanone

CAS 705959-83-7C₁₇H₂₄N₂O₃S

1-[4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)piperidin-1-yl]-2,2-dimethylpropan-1-one chemical structure, C20H28N2O2, CAS 945359-67-1

1-[4-(3,4-Dihydroisoquinolin-2(1H)-ylcarbonyl)piperidin-1-yl]-2,2-dimethylpropan-1-one

CAS 945359-67-1C₂₀H₂₈N₂O₂

2-(Piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride chemical structure, C15H21ClN2O, CAS 73415-60-8

2-(Piperidine-4-carbonyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

CAS 73415-60-8C₁₅H₂₁ClN₂O

3,4-Dihydro-1H-isoquinolin-2-yl-(1-prop-2-ynylpiperidin-4-yl)methanone chemical structure, C18H22N2O, CAS 1427910-52-8

3,4-Dihydro-1H-isoquinolin-2-yl-(1-prop-2-ynylpiperidin-4-yl)methanone

CAS 1427910-52-8C₁₈H₂₂N₂O

N-Methyl-2-(1-prop-2-enoylpiperidine-4-carbonyl)-3,4-dihydro-1H-isoquinoline-5-sulfonamide chemical structure, C19H25N3O4S, CAS 2361856-01-9

N-Methyl-2-(1-prop-2-enoylpiperidine-4-carbonyl)-3,4-dihydro-1H-isoquinoline-5-sulfonamide

CAS 2361856-01-9C₁₉H₂₅N₃O₄S

1-[4-(6,7-Dichloro-1-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one chemical structure, C19H22Cl2N2O2, CAS 2361772-45-2

1-[4-(6,7-Dichloro-1-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one

CAS 2361772-45-2C₁₉H₂₂Cl₂N₂O₂

1-{4-[7-Fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]piperidin-1-yl}prop-2-en-1-one chemical structure, C21H27FN2O2, CAS 2361728-55-2

1-{4-[7-Fluoro-1-(propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]piperidin-1-yl}prop-2-en-1-one

CAS 2361728-55-2C₂₁H₂₇FN₂O₂

1-[4-(6-Propoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one chemical structure, C21H28N2O3, CAS 2361748-71-0

1-[4-(6-Propoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one

CAS 2361748-71-0C₂₁H₂₈N₂O₃

2-(1-Prop-2-enoylpiperidine-4-carbonyl)-3,4-dihydro-1H-isoquinoline-5-sulfonamide chemical structure, C18H23N3O4S, CAS 2361897-34-7

2-(1-Prop-2-enoylpiperidine-4-carbonyl)-3,4-dihydro-1H-isoquinoline-5-sulfonamide

CAS 2361897-34-7C₁₈H₂₃N₃O₄S

1-[4-(6-Methoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one chemical structure, C19H24N2O3, CAS 2361838-70-0

1-[4-(6-Methoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one

CAS 2361838-70-0C₁₉H₂₄N₂O₃

(3S)-2-(1-Prop-2-enoylpiperidine-4-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide chemical structure, C19H23N3O3, CAS 2361585-61-5

(3S)-2-(1-Prop-2-enoylpiperidine-4-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide

CAS 2361585-61-5C₁₉H₂₃N₃O₃

1-[4-(5,7-Dichloro-1-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one chemical structure, C19H22Cl2N2O2, CAS 2411200-11-6

1-[4-(5,7-Dichloro-1-methyl-3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one

CAS 2411200-11-6C₁₉H₂₂Cl₂N₂O₂

1-[4-(6-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one chemical structure, C22H30N2O2, CAS 2411304-91-9

1-[4-(6-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one

CAS 2411304-91-9C₂₂H₃₀N₂O₂

1-[4-(6,8-Dichloro-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one chemical structure, C18H20Cl2N2O2, CAS 2411301-82-9

1-[4-(6,8-Dichloro-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one

CAS 2411301-82-9C₁₈H₂₀Cl₂N₂O₂

1-[4-(5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one chemical structure, C18H20Cl2N2O2, CAS 2411193-98-9

1-[4-(5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl]prop-2-en-1-one

CAS 2411193-98-9C₁₈H₂₀Cl₂N₂O₂