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Murcko scaffold

Ring system with 5 rings and 24 atoms

187 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
24
Chemicals
187
With full pages
13
Scaffold SMILES

c1ccc(C2=NN3C(C2)c2ccccc2OC32CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(C2=NN3C(C2)c2ccccc2OC32CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 187 chemicals

2-(4-Methoxyphenyl)-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine] chemical structure, C22H25N3O2, CAS 375829-37-1
2-(4-Methoxyphenyl)-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine]
CAS 375829-37-1C22H25N3O2
1-(7-Methoxy-2-phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone chemical structure, C23H25N3O3, CAS 496021-87-5
1-(7-Methoxy-2-phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
CAS 496021-87-5C23H25N3O3
1-(7-Methoxy-2-(p-tolyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone chemical structure, C24H27N3O3, CAS 890096-22-7
1-(7-Methoxy-2-(p-tolyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
CAS 890096-22-7C24H27N3O3
1-[2-(4-Bromophenyl)-7-methoxyspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]-1'-yl]ethanone chemical structure, C23H24BrN3O3, CAS 890096-20-5
1-[2-(4-Bromophenyl)-7-methoxyspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]-1'-yl]ethanone
CAS 890096-20-5C23H24BrN3O3
9-Bromo-2-(4-bromophenyl)-1'-propyl-1,10B-dihydrospiro(benzo(E)pyrazolo(1,5-C)(1,3)oxazine-5,4'-piperidine) chemical structure, C23H25Br2N3O, CAS 303094-70-4
9-Bromo-2-(4-bromophenyl)-1'-propyl-1,10B-dihydrospiro(benzo(E)pyrazolo(1,5-C)(1,3)oxazine-5,4'-piperidine)
CAS 303094-70-4C23H25Br2N3O
1-(7-Methoxy-2-(4-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone chemical structure, C24H27N3O4, CAS 893791-23-6
1-(7-Methoxy-2-(4-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
CAS 893791-23-6C24H27N3O4
7,9-Dichloro-2-(4-chlorophenyl)-1'-propyl-1,10B-dihydrospiro(benzo(E)pyrazolo(1,5-C)(1,3)oxazine-5,4'-piperidine) chemical structure, C23H24Cl3N3O, CAS 303104-46-3
7,9-Dichloro-2-(4-chlorophenyl)-1'-propyl-1,10B-dihydrospiro(benzo(E)pyrazolo(1,5-C)(1,3)oxazine-5,4'-piperidine)
CAS 303104-46-3C23H24Cl3N3O
9-Bromo-1'-methyl-2-phenylspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine] chemical structure, C21H22BrN3O, CAS 374921-75-2
9-Bromo-1'-methyl-2-phenylspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]
CAS 374921-75-2C21H22BrN3O
1-{2'-[4-(Difluoromethoxy)phenyl]-7'-methoxy-1',10b'-dihydro-1H-spiro[piperidine-4,5'-pyrazolo[1,5-c][1,3]benzoxazin]-1-yl}ethanone chemical structure, C24H25F2N3O4, CAS 890096-00-1
1-{2'-[4-(Difluoromethoxy)phenyl]-7'-methoxy-1',10b'-dihydro-1H-spiro[piperidine-4,5'-pyrazolo[1,5-c][1,3]benzoxazin]-1-yl}ethanone
CAS 890096-00-1C24H25F2N3O4
1-(2-(4-Hydroxy-3-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone chemical structure, C23H25N3O4, CAS 890095-90-6
1-(2-(4-Hydroxy-3-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
CAS 890095-90-6C23H25N3O4
1-(9-Bromo-2-(4-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone chemical structure, C23H24BrN3O3, CAS 879449-93-1
1-(9-Bromo-2-(4-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
CAS 879449-93-1C23H24BrN3O3
2-(3,4-Dimethoxyphenyl)-1'-methylsulfonylspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine] chemical structure, C23H27N3O5S, CAS 861651-60-7
2-(3,4-Dimethoxyphenyl)-1'-methylsulfonylspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]
CAS 861651-60-7C23H27N3O5S
1-(9-Bromo-2-phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone chemical structure, C22H22BrN3O2, CAS 890096-52-3
1-(9-Bromo-2-phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
CAS 890096-52-3C22H22BrN3O2
7,9-Dichloro-2-(4-methoxyphenyl)-1'-propyl-1,10B-dihydrospiro[benzo[E]pyrazolo[1,5-C][1,3]oxazine-5,4'-piperidine] chemical structure, C24H27Cl2N3O2, CAS 303104-58-7
7,9-Dichloro-2-(4-methoxyphenyl)-1'-propyl-1,10B-dihydrospiro[benzo[E]pyrazolo[1,5-C][1,3]oxazine-5,4'-piperidine]
CAS 303104-58-7C24H27Cl2N3O2
9-Bromo-2-phenyl-1'-propyl-1,10B-dihydrospiro(benzo(E)pyrazolo(1,5-C)(1,3)oxazine-5,4'-piperidine) chemical structure, C23H26BrN3O, CAS 303104-51-0
9-Bromo-2-phenyl-1'-propyl-1,10B-dihydrospiro(benzo(E)pyrazolo(1,5-C)(1,3)oxazine-5,4'-piperidine)
CAS 303104-51-0C23H26BrN3O
9-Chloro-2-(4-methoxyphenyl)-1'-methylspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine] chemical structure, C22H24ClN3O2, CAS 786674-04-2
9-Chloro-2-(4-methoxyphenyl)-1'-methylspiro[1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazine-5,4'-piperidine]
CAS 786674-04-2C22H24ClN3O2
1'-Ethyl-2-phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine] chemical structure, C22H25N3O, CAS 840477-93-2
1'-Ethyl-2-phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine]
CAS 840477-93-2C22H25N3O
2-Bromo-9-(4-chlorophenyl)-14-methylspiro[10aH-benzo[e]2-pyrazolino[1,5-c]1,3-oxazine-6,4'-piperidine] chemical structure, C21H21BrClN3O, CAS 499212-09-8
2-Bromo-9-(4-chlorophenyl)-14-methylspiro[10aH-benzo[e]2-pyrazolino[1,5-c]1,3-oxazine-6,4'-piperidine]
CAS 499212-09-8C21H21BrClN3O
4-(1'-Ethyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)-2-methoxyphenol chemical structure, C23H27N3O3, CAS 840473-75-8
4-(1'-Ethyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)-2-methoxyphenol
CAS 840473-75-8C23H27N3O3
4-(1'-Isopropyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)-2-methoxyphenol chemical structure, C24H29N3O3, CAS 489415-47-6
4-(1'-Isopropyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)-2-methoxyphenol
CAS 489415-47-6C24H29N3O3
1-(2-Phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone chemical structure, C22H23N3O2, CAS 638144-89-5
1-(2-Phenyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone
CAS 638144-89-5C22H23N3O2
2-(4-Bromophenyl)-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine] chemical structure, C21H22BrN3O, CAS 375357-96-3
2-(4-Bromophenyl)-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine]
CAS 375357-96-3C21H22BrN3O
1'-Methyl-2-(p-tolyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine] chemical structure, C22H25N3O, CAS 375350-33-7
1'-Methyl-2-(p-tolyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine]
CAS 375350-33-7C22H25N3O
2'-(4-Fluorophenyl)-1-methyl-1',10b'-dihydrospiro[piperidine-4,5'-pyrazolo[1,5-c][1,3]benzoxazine] chemical structure, C21H22FN3O, CAS 375837-27-7
2'-(4-Fluorophenyl)-1-methyl-1',10b'-dihydrospiro[piperidine-4,5'-pyrazolo[1,5-c][1,3]benzoxazine]
CAS 375837-27-7C21H22FN3O