Murcko scaffold

Ring system with 5 rings and 24 atoms

187 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 24
Chemicals: 187
With full pages: 13

Scaffold SMILES

c1ccc(C2=NN3C(C2)c2ccccc2OC32CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(C2=NN3C(C2)c2ccccc2OC32CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 97 to 144 of 187 chemicals

3-(1'-Ethyl-7-methoxy-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899972-66-8C₂₃H₂₇N₃O₃

1-(2-(3-Hydroxyphenyl)-7-methoxy-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 941984-35-6C₂₃H₂₅N₃O₄

3-(7-Ethoxy-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899983-99-4C₂₃H₂₇N₃O₃

1-(7-Ethoxy-2-(3-hydroxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 941945-98-8C₂₄H₂₇N₃O₄

Ethyl 7-ethoxy-2-(3-hydroxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine]-1'-carboxylate

CAS 941941-06-6C₂₅H₂₉N₃O₅

1-(2-(3,4-Dimethylphenyl)-7-methoxy-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 899984-07-7C₂₅H₂₉N₃O₃

$Ethyl 4'-(3,4-dimethylphenyl)-10'-methoxy-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate chemical structure, C26H31N3O4, CAS 899728-23-5$

Ethyl 4'-(3,4-dimethylphenyl)-10'-methoxy-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate

CAS 899728-23-5C₂₆H₃₁N₃O₄

$1-[4'-(3,4-Dimethylphenyl)-10'-ethoxy-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one chemical structure, C26H31N3O3, CAS 899972-76-0$

1-[4'-(3,4-Dimethylphenyl)-10'-ethoxy-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one

CAS 899972-76-0C₂₆H₃₁N₃O₃

Ethyl 9'-chloro-2'-(2-hydroxyphenyl)-1',10b'-dihydro-1H-spiro[piperidine-4,5'-pyrazolo[1,5-c][1,3]benzoxazine]-1-carboxylate

CAS 899971-98-3C₂₃H₂₄ClN₃O₄

2-(1'-Methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899971-92-7C₂₁H₂₃N₃O₂

$2-{1-Ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol chemical structure, C22H25N3O2, CAS 899727-51-6$

2-{1-Ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol

CAS 899727-51-6C₂₂H₂₅N₃O₂

2-(1'-Propyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899983-59-6C₂₃H₂₇N₃O₂

$1-[4'-(2-Hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one chemical structure, C22H23N3O3, CAS 899971-94-9$

1-[4'-(2-Hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one

CAS 899971-94-9C₂₂H₂₃N₃O₃

$Ethyl 4'-(2-hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate chemical structure, C23H25N3O4, CAS 899983-61-0$

Ethyl 4'-(2-hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate

CAS 899983-61-0C₂₃H₂₅N₃O₄

$2-[1-(Propan-2-yl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl]phenol chemical structure, C23H27N3O2, CAS 899727-53-8$

2-[1-(Propan-2-yl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl]phenol

CAS 899727-53-8C₂₃H₂₇N₃O₂

$2-{12'-Chloro-1-methyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol chemical structure, C21H22ClN3O2, CAS 899971-96-1$

2-{12'-Chloro-1-methyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol

CAS 899971-96-1C₂₁H₂₂ClN₃O₂

$2-{12'-Chloro-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol chemical structure, C22H24ClN3O2, CAS 899727-55-0$

2-{12'-Chloro-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol

CAS 899727-55-0C₂₂H₂₄ClN₃O₂

1-(9-Chloro-2-(2-hydroxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 899983-62-1C₂₂H₂₂ClN₃O₃

$2-{12'-Bromo-1-methyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol chemical structure, C21H22BrN3O2, CAS 899983-63-2$

2-{12'-Bromo-1-methyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol

CAS 899983-63-2C₂₁H₂₂BrN₃O₂

1-(9-Bromo-2-(2-hydroxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 899727-56-1C₂₂H₂₂BrN₃O₃

Ethyl 9-bromo-2-(2-hydroxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine]-1'-carboxylate

CAS 899972-00-0C₂₃H₂₄BrN₃O₄

4-Methyl-2-(1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899983-64-3C₂₂H₂₅N₃O₂

2-(1'-Ethyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)-4-methylphenol

CAS 899727-57-2C₂₃H₂₇N₃O₂

$1-[4'-(2-Hydroxy-5-methylphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one chemical structure, C23H25N3O3, CAS 899972-02-2$

1-[4'-(2-Hydroxy-5-methylphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one

CAS 899972-02-2C₂₃H₂₅N₃O₃

Ring system with 5 rings and 24 atoms

Chemicals with this scaffold

Related scaffolds