Murcko scaffold

Ring system with 5 rings and 24 atoms

187 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 24
Chemicals: 187
With full pages: 13

Scaffold SMILES

c1ccc(C2=NN3C(C2)c2ccccc2OC32CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(C2=NN3C(C2)c2ccccc2OC32CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 145 to 187 of 187 chemicals

2-(1'-Ethyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)benzene-1,4-diol

CAS 899727-73-2C₂₂H₂₅N₃O₃

2-(1'-Propyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)benzene-1,4-diol

CAS 899983-74-5C₂₃H₂₇N₃O₃

1-(2-(2,5-Dihydroxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 899972-22-6C₂₂H₂₃N₃O₄

$Ethyl 4'-(2,5-dihydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate chemical structure, C23H25N3O5, CAS 899972-24-8$

Ethyl 4'-(2,5-dihydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate

CAS 899972-24-8C₂₃H₂₅N₃O₅

$2-{12'-Chloro-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}benzene-1,4-diol chemical structure, C22H24ClN3O3, CAS 941945-96-6$

2-{12'-Chloro-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}benzene-1,4-diol

CAS 941945-96-6C₂₂H₂₄ClN₃O₃

$Ethyl 4'-(4-hydroxy-3-methoxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate chemical structure, C24H27N3O5, CAS 899727-75-4$

Ethyl 4'-(4-hydroxy-3-methoxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate

CAS 899727-75-4C₂₄H₂₇N₃O₅

4-(9-Chloro-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)-2-methoxyphenol

CAS 899983-75-6C₂₂H₂₄ClN₃O₃

$4-{12'-Chloro-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}-2-methoxyphenol chemical structure, C23H26ClN3O3, CAS 899983-76-7$

4-{12'-Chloro-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}-2-methoxyphenol

CAS 899983-76-7C₂₃H₂₆ClN₃O₃

1-(9-Chloro-2-(4-hydroxy-3-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 899727-77-6C₂₃H₂₄ClN₃O₄

Ethyl 9-chloro-2-(4-hydroxy-3-methoxyphenyl)-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidine]-1'-carboxylate

CAS 899972-26-0C₂₄H₂₆ClN₃O₅

2-(7-Methoxy-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899727-98-1C₂₂H₂₅N₃O₃

2-(1'-Ethyl-7-methoxy-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899972-48-6C₂₃H₂₇N₃O₃

2-(7-Methoxy-1'-propyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 899983-88-1C₂₄H₂₉N₃O₃

1-(2-(2-Hydroxyphenyl)-7-methoxy-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-1'-yl)ethanone

CAS 899727-99-2C₂₃H₂₅N₃O₄

$Ethyl 4'-(2-hydroxyphenyl)-10'-methoxy-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate chemical structure, C24H27N3O5, CAS 899972-50-0$

Ethyl 4'-(2-hydroxyphenyl)-10'-methoxy-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate

CAS 899972-50-0C₂₄H₂₇N₃O₅

2-(1'-Isopropyl-7-methoxy-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)phenol

CAS 941894-89-9C₂₄H₂₉N₃O₃

$2-{10'-Ethoxy-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol chemical structure, C24H29N3O3, CAS 899983-89-2$

2-{10'-Ethoxy-1-ethyl-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}phenol

CAS 899983-89-2C₂₄H₂₉N₃O₃

$1-[10'-Ethoxy-4'-(2-hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one chemical structure, C24H27N3O4, CAS 899728-01-9$

1-[10'-Ethoxy-4'-(2-hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-1-yl]ethan-1-one

CAS 899728-01-9C₂₄H₂₇N₃O₄

$Ethyl 10'-ethoxy-4'-(2-hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate chemical structure, C25H29N3O5, CAS 899972-52-2$

Ethyl 10'-ethoxy-4'-(2-hydroxyphenyl)-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraene-1-carboxylate

CAS 899972-52-2C₂₅H₂₉N₃O₅

2-(7-Methoxy-1'-methyl-1,10b-dihydrospiro[benzo[e]pyrazolo[1,5-c][1,3]oxazine-5,4'-piperidin]-2-yl)-4-methylphenol

CAS 899983-90-5C₂₃H₂₇N₃O₃

$2-{1-Ethyl-10'-methoxy-8'-oxa-5',6'-diazaspiro[piperidine-4,7'-tricyclo[7.4.0.0^{2,6}]tridecane]-1'(9'),4',10',12'-tetraen-4'-yl}-4-methylphenol chemical structure, C24H29N3O3, CAS 899728-03-1$