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Murcko scaffold

2-Phenylcyclobutanone scaffold

72 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
72
With full pages
9
Scaffold SMILES

O=C1CCC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenylcyclobutanone page
Murcko scaffold O=C1CCC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

Cyclobutanone, 2-(4-methylphenyl)- chemical structure, C11H12O, CAS 87639-46-1
Cyclobutanone, 2-(4-methylphenyl)-
CAS 87639-46-1C11H12O
2-Phenylcyclobutanone chemical structure, C10H10O, CAS 42436-86-2
2-Phenylcyclobutanone
CAS 42436-86-2C10H10O
2-Methyl-2-phenylcyclobutan-1-one chemical structure, C11H12O, CAS 75750-06-0
2-Methyl-2-phenylcyclobutan-1-one
CAS 75750-06-0C11H12O
2-(4-Methoxyphenyl)cyclobutan-1-one chemical structure, C11H12O2, CAS 70106-27-3
2-(4-Methoxyphenyl)cyclobutan-1-one
CAS 70106-27-3C11H12O2
2-(Dimethoxymethyl)-2-phenylcyclobutan-1-one chemical structure, C13H16O3, CAS 80706-76-9
2-(Dimethoxymethyl)-2-phenylcyclobutan-1-one
CAS 80706-76-9C13H16O3
2-(Hydroxymethyl)-2-phenylcyclobutan-1-one chemical structure, C11H12O2, CAS 196502-85-9
2-(Hydroxymethyl)-2-phenylcyclobutan-1-one
CAS 196502-85-9C11H12O2
2-[4-(tert-Butyl)phenyl]cyclobutanone chemical structure, C14H18O, CAS 2169654-18-4
2-[4-(tert-Butyl)phenyl]cyclobutanone
CAS 2169654-18-4C14H18O
2-(4-Ethoxyphenyl)-2-methylcyclobutan-1-one chemical structure, C13H16O2, CAS 671782-27-7
2-(4-Ethoxyphenyl)-2-methylcyclobutan-1-one
CAS 671782-27-7C13H16O2
2-(4-Bromophenyl)-2-methylcyclobutan-1-one chemical structure, C11H11BrO, CAS 671782-29-9
2-(4-Bromophenyl)-2-methylcyclobutan-1-one
CAS 671782-29-9C11H11BrO
2-(2-Chlorophenyl)cyclobutan-1-one chemical structure, C10H9ClO, CAS 1242029-75-9
2-(2-Chlorophenyl)cyclobutan-1-one
CAS 1242029-75-9C10H9ClO
2-(3,4-Dimethoxyphenyl)cyclobutanone chemical structure, C12H14O3, CAS 2096972-41-5
2-(3,4-Dimethoxyphenyl)cyclobutanone
CAS 2096972-41-5C12H14O3
(2S)-2-(4-tert-Butylphenyl)cyclobutan-1-one chemical structure, C14H18O, CAS 918831-67-1
(2S)-2-(4-tert-Butylphenyl)cyclobutan-1-one
CAS 918831-67-1C14H18O
2-(2,5-Dimethoxy-4-methylphenyl)cyclobutanone chemical structure, C13H16O3, CAS 90791-16-5
2-(2,5-Dimethoxy-4-methylphenyl)cyclobutanone
CAS 90791-16-5C13H16O3
3,3-Dimethyl-2-phenylcyclobutan-1-one chemical structure, C12H14O, CAS 118526-95-7
3,3-Dimethyl-2-phenylcyclobutan-1-one
CAS 118526-95-7C12H14O
2-(4-Chlorophenyl)cyclobutanone chemical structure, C10H9ClO, CAS 162521-18-8
2-(4-Chlorophenyl)cyclobutanone
CAS 162521-18-8C10H9ClO
2-(2,4-Dichlorophenyl)cyclobutanone chemical structure, C10H8Cl2O, CAS 1261038-31-6
2-(2,4-Dichlorophenyl)cyclobutanone
CAS 1261038-31-6C10H8Cl2O
2-(2,6-Difluorophenyl)cyclobutanone chemical structure, C10H8F2O, CAS 1637318-88-7
2-(2,6-Difluorophenyl)cyclobutanone
CAS 1637318-88-7C10H8F2O
2-(2,4-Difluorophenyl)cyclobutanone chemical structure, C10H8F2O, CAS 1644256-04-1
2-(2,4-Difluorophenyl)cyclobutanone
CAS 1644256-04-1C10H8F2O
2-(2-Fluorophenyl)cyclobutanone chemical structure, C10H9FO, CAS 1823945-01-2
2-(2-Fluorophenyl)cyclobutanone
CAS 1823945-01-2C10H9FO
2-(3-Fluorophenyl)cyclobutanone chemical structure, C10H9FO, CAS 1823357-80-7
2-(3-Fluorophenyl)cyclobutanone
CAS 1823357-80-7C10H9FO
2-(4-Fluorophenyl)cyclobutan-1-one chemical structure, C10H9FO, CAS 1261038-29-2
2-(4-Fluorophenyl)cyclobutan-1-one
CAS 1261038-29-2C10H9FO
2-(2-Methoxyphenyl)cyclobutanone chemical structure, C11H12O2, CAS 1242029-76-0
2-(2-Methoxyphenyl)cyclobutanone
CAS 1242029-76-0C11H12O2
2-(3-Methoxyphenyl)cyclobutanone chemical structure, C11H12O2, CAS 1823899-15-5
2-(3-Methoxyphenyl)cyclobutanone
CAS 1823899-15-5C11H12O2
2-(2-Bromo-5-fluorophenyl)cyclobutanone chemical structure, C10H8BrFO, CAS 2098104-33-5
2-(2-Bromo-5-fluorophenyl)cyclobutanone
CAS 2098104-33-5C10H8BrFO