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Murcko scaffold

3-Phenylcyclobutanone scaffold

736 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
736
With full pages
45
Scaffold SMILES

O=C1CC(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenylcyclobutanone page
Murcko scaffold O=C1CC(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 736 chemicals

3-Phenylcyclobutanone chemical structure, C10H10O, CAS 52784-31-3
3-Phenylcyclobutanone
CAS 52784-31-3C10H10O
(4-(3-Oxocyclobutyl)phenyl)boronic acid chemical structure, C10H11BO3, CAS 254893-03-3
(4-(3-Oxocyclobutyl)phenyl)boronic acid
CAS 254893-03-3C10H11BO3
3-(4-Chlorophenyl)cyclobutan-1-one chemical structure, C10H9ClO, CAS 152714-07-3
3-(4-Chlorophenyl)cyclobutan-1-one
CAS 152714-07-3C10H9ClO
3-(4-Bromophenyl)cyclobutan-1-one chemical structure, C10H9BrO, CAS 254892-91-6
3-(4-Bromophenyl)cyclobutan-1-one
CAS 254892-91-6C10H9BrO
Cyclobutanone, 2,2-dichloro-3-phenyl- chemical structure, C10H8Cl2O, CAS 13866-28-9
Cyclobutanone, 2,2-dichloro-3-phenyl-
CAS 13866-28-9C10H8Cl2O
3-(4-Bromophenyl)-2,2-dichlorocyclobutan-1-one chemical structure, C10H7BrCl2O, CAS 254892-87-0
3-(4-Bromophenyl)-2,2-dichlorocyclobutan-1-one
CAS 254892-87-0C10H7BrCl2O
3-Methyl-3-phenylcyclobutan-1-one chemical structure, C11H12O, CAS 151990-53-3
3-Methyl-3-phenylcyclobutan-1-one
CAS 151990-53-3C11H12O
2,2-Dichloro-3-(4-chlorophenyl)cyclobutan-1-one chemical structure, C10H7Cl3O, CAS 191019-76-8
2,2-Dichloro-3-(4-chlorophenyl)cyclobutan-1-one
CAS 191019-76-8C10H7Cl3O
3-(4-Methoxyphenyl)-3-methylcyclobutan-1-one chemical structure, C12H14O2, CAS 401895-06-5
3-(4-Methoxyphenyl)-3-methylcyclobutan-1-one
CAS 401895-06-5C12H14O2
3-(4-Fluorophenyl)cyclobutan-1-one chemical structure, C10H9FO, CAS 143589-42-8
3-(4-Fluorophenyl)cyclobutan-1-one
CAS 143589-42-8C10H9FO
3-(4-Methoxyphenyl)cyclobutan-1-one chemical structure, C11H12O2, CAS 52498-02-9
3-(4-Methoxyphenyl)cyclobutan-1-one
CAS 52498-02-9C11H12O2
Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl- chemical structure, C12H13ClO, CAS 89451-88-7
Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl-
CAS 89451-88-7C12H13ClO
Cyclobutanone, 2,2-dichloro-3-methyl-3-(4-methylphenyl)- chemical structure, C12H12Cl2O, CAS 193003-73-5
Cyclobutanone, 2,2-dichloro-3-methyl-3-(4-methylphenyl)-
CAS 193003-73-5C12H12Cl2O
Cyclobutanone, 3-(2-ethenylphenyl)-3-hexyl- chemical structure, C18H24O, CAS 918299-12-4
Cyclobutanone, 3-(2-ethenylphenyl)-3-hexyl-
CAS 918299-12-4C18H24O
Cyclobutanone, 3-(2-ethenyl-4-fluorophenyl)-3-hexyl- chemical structure, C18H23FO, CAS 918299-15-7
Cyclobutanone, 3-(2-ethenyl-4-fluorophenyl)-3-hexyl-
CAS 918299-15-7C18H23FO
2,2-Dimethyl-3-phenylcyclobutan-1-one chemical structure, C12H14O, CAS 4056-87-5
2,2-Dimethyl-3-phenylcyclobutan-1-one
CAS 4056-87-5C12H14O
2-Methyl-3-phenylcyclobutan-1-one chemical structure, C11H12O, CAS 117543-11-0
2-Methyl-3-phenylcyclobutan-1-one
CAS 117543-11-0C11H12O
4-Bromo-3-(4-chlorophenyl)-2,2-dimethylcyclobutan-1-one chemical structure, C12H12BrClO, CAS 89451-89-8
4-Bromo-3-(4-chlorophenyl)-2,2-dimethylcyclobutan-1-one
CAS 89451-89-8C12H12BrClO
2,2-Dichloro-3-(4-methylphenyl)cyclobutan-1-one chemical structure, C11H10Cl2O, CAS 98775-08-7
2,2-Dichloro-3-(4-methylphenyl)cyclobutan-1-one
CAS 98775-08-7C11H10Cl2O
Cyclobutanone, 2-methoxy-3-methyl-3-phenyl-, (2R-trans)- chemical structure, C12H14O2, CAS 104013-05-0
Cyclobutanone, 2-methoxy-3-methyl-3-phenyl-, (2R-trans)-
CAS 104013-05-0C12H14O2
3-(4-tert-Butylphenyl)cyclobutan-1-one chemical structure, C14H18O, CAS 115614-42-1
3-(4-tert-Butylphenyl)cyclobutan-1-one
CAS 115614-42-1C14H18O
2,2-Dichloro-3-methyl-3-phenylcyclobutanone chemical structure, C11H10Cl2O, CAS 136527-27-0
2,2-Dichloro-3-methyl-3-phenylcyclobutanone
CAS 136527-27-0C11H10Cl2O
3-(3-Bromophenyl)cyclobutan-1-one chemical structure, C10H9BrO, CAS 885267-15-2
3-(3-Bromophenyl)cyclobutan-1-one
CAS 885267-15-2C10H9BrO
3-(4-Fluorophenyl)-2,2-dimethylcyclobutan-1-one chemical structure, C12H13FO, CAS 1501751-05-8
3-(4-Fluorophenyl)-2,2-dimethylcyclobutan-1-one
CAS 1501751-05-8C12H13FO