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Murcko scaffold

1-Phenylazetidin-2-one scaffold

162 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
162
With full pages
32
Scaffold SMILES

O=C1CCN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylazetidin-2-one page
Murcko scaffold O=C1CCN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 162 chemicals

N-(2-Chloromethylphenyl)-3,3-difluoroazetidin-2-one chemical structure, C10H8ClF2NO, CAS 131230-67-6
N-(2-Chloromethylphenyl)-3,3-difluoroazetidin-2-one
CAS 131230-67-6C10H8ClF2NO
Diethyl 3-chloro-4-oxo-1-phenylazetidine-2,2-dicarboxylate chemical structure, C15H16ClNO5, CAS 13277-41-3
Diethyl 3-chloro-4-oxo-1-phenylazetidine-2,2-dicarboxylate
CAS 13277-41-3C15H16ClNO5
1-Phenylazetidin-2-one chemical structure, C9H9NO, CAS 5099-95-6
1-Phenylazetidin-2-one
CAS 5099-95-6C9H9NO
3,3-Dimethyl-1-(3-nitrophenyl)azetidin-2-one chemical structure, C11H12N2O3, CAS 34449-03-1
3,3-Dimethyl-1-(3-nitrophenyl)azetidin-2-one
CAS 34449-03-1C11H12N2O3
3-(Dimethylamino)-2-[4-(3,3-dimethyl-2-oxo-1-azetanyl)phenyl]acrylonitrile chemical structure, C16H19N3O, CAS 303985-91-3
3-(Dimethylamino)-2-[4-(3,3-dimethyl-2-oxo-1-azetanyl)phenyl]acrylonitrile
CAS 303985-91-3C16H19N3O
3,3-Dimethyl-1-[4-(trifluoromethoxy)phenyl]azetidin-2-one chemical structure, C12H12F3NO2, CAS 303986-00-7
3,3-Dimethyl-1-[4-(trifluoromethoxy)phenyl]azetidin-2-one
CAS 303986-00-7C12H12F3NO2
1-(4-Isopropylphenyl)-3,3-dimethyl-2-azetanone chemical structure, C14H19NO, CAS 303986-04-1
1-(4-Isopropylphenyl)-3,3-dimethyl-2-azetanone
CAS 303986-04-1C14H19NO
3-(3,3-Dimethyl-2-oxoazetidin-1-yl)benzonitrile chemical structure, C12H12N2O, CAS 341965-81-9
3-(3,3-Dimethyl-2-oxoazetidin-1-yl)benzonitrile
CAS 341965-81-9C12H12N2O
Ethyl 4-(3,3-dimethyl-2-oxoazetidin-1-yl)benzoate chemical structure, C14H17NO3, CAS 341965-86-4
Ethyl 4-(3,3-dimethyl-2-oxoazetidin-1-yl)benzoate
CAS 341965-86-4C14H17NO3
1-(3-Chloro-2-methylphenyl)-3,3-dimethyl-2-azetanone chemical structure, C12H14ClNO, CAS 341965-92-2
1-(3-Chloro-2-methylphenyl)-3,3-dimethyl-2-azetanone
CAS 341965-92-2C12H14ClNO
1-(3,5-Dimethylphenyl)-3,3-dimethyl-2-azetanone chemical structure, C13H17NO, CAS 341965-96-6
1-(3,5-Dimethylphenyl)-3,3-dimethyl-2-azetanone
CAS 341965-96-6C13H17NO
1-[4-(Dimethylamino)phenyl]-3,3-dimethyl-2-azetanone chemical structure, C13H18N2O, CAS 341966-01-6
1-[4-(Dimethylamino)phenyl]-3,3-dimethyl-2-azetanone
CAS 341966-01-6C13H18N2O
1-(4-Fluorophenyl)-3,3-dimethylazetidin-2-one chemical structure, C11H12FNO, CAS 341966-04-9
1-(4-Fluorophenyl)-3,3-dimethylazetidin-2-one
CAS 341966-04-9C11H12FNO
3,3-Dimethyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one chemical structure, C12H12F3NO, CAS 339015-91-7
3,3-Dimethyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one
CAS 339015-91-7C12H12F3NO
1-(4-Acetylphenyl)-3,3-dimethylazetidin-2-one chemical structure, C13H15NO2, CAS 339015-93-9
1-(4-Acetylphenyl)-3,3-dimethylazetidin-2-one
CAS 339015-93-9C13H15NO2
1-(2,4-Dichlorophenyl)-3,3-dimethyl-2-azetanone chemical structure, C11H11Cl2NO, CAS 280562-66-5
1-(2,4-Dichlorophenyl)-3,3-dimethyl-2-azetanone
CAS 280562-66-5C11H11Cl2NO
1-{4-[(2E)-3-(Dimethylamino)prop-2-enoyl]phenyl}-3,3-dimethylazetidin-2-one chemical structure, C16H20N2O2, CAS 339100-33-3
1-{4-[(2E)-3-(Dimethylamino)prop-2-enoyl]phenyl}-3,3-dimethylazetidin-2-one
CAS 339100-33-3C16H20N2O2
1-(4-Iodophenyl)-3,3-dimethylazetidin-2-one chemical structure, C11H12INO, CAS 339100-84-4
1-(4-Iodophenyl)-3,3-dimethylazetidin-2-one
CAS 339100-84-4C11H12INO
Methyl 2-(3,3-dimethyl-2-oxoazetidin-1-yl)benzoate chemical structure, C13H15NO3, CAS 339100-88-8
Methyl 2-(3,3-dimethyl-2-oxoazetidin-1-yl)benzoate
CAS 339100-88-8C13H15NO3
1-[3,5-Bis(trifluoromethyl)phenyl]-3,3-dimethylazetidin-2-one chemical structure, C13H11F6NO, CAS 478261-83-5
1-[3,5-Bis(trifluoromethyl)phenyl]-3,3-dimethylazetidin-2-one
CAS 478261-83-5C13H11F6NO
1-(3,5-Dimethoxyphenyl)-3,3-dimethyl-2-azetanone chemical structure, C13H17NO3, CAS 478261-91-5
1-(3,5-Dimethoxyphenyl)-3,3-dimethyl-2-azetanone
CAS 478261-91-5C13H17NO3
1-(3,5-Dichlorophenyl)-3,3-dimethyl-2-azetanone chemical structure, C11H11Cl2NO, CAS 478261-96-0
1-(3,5-Dichlorophenyl)-3,3-dimethyl-2-azetanone
CAS 478261-96-0C11H11Cl2NO
4-(3,3-Dimethyl-2-oxo-1-azetanyl)benzenesulfonamide chemical structure, C11H14N2O3S, CAS 478261-97-1
4-(3,3-Dimethyl-2-oxo-1-azetanyl)benzenesulfonamide
CAS 478261-97-1C11H14N2O3S
2-[4-(3,3-Dimethyl-2-oxo-1-azetanyl)phenyl]acetonitrile chemical structure, C13H14N2O, CAS 478262-00-9
2-[4-(3,3-Dimethyl-2-oxo-1-azetanyl)phenyl]acetonitrile
CAS 478262-00-9C13H14N2O