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Murcko scaffold

5-Phenyl-1H-pyrazin-2-one scaffold

101 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
101
With full pages
3
Scaffold SMILES

O=c1cnc(-c2ccccc2)c[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-Phenyl-1H-pyrazin-2-one page
Murcko scaffold O=c1cnc(-c2ccccc2)c[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 101 chemicals

5-Phenyl-1H-pyrazin-2-one chemical structure, C10H8N2O, CAS 25844-72-8
5-Phenyl-1H-pyrazin-2-one
CAS 25844-72-8C10H8N2O
5-(4-Chlorophenyl)-1-hydroxy-2(1H)-pyrazinone chemical structure, C10H7ClN2O2, CAS 76849-87-1
5-(4-Chlorophenyl)-1-hydroxy-2(1H)-pyrazinone
CAS 76849-87-1C10H7ClN2O2
1-Hydroxy-3-methyl-5-phenyl-2(1H)-pyrazinone chemical structure, C11H10N2O2, CAS 400087-77-6
1-Hydroxy-3-methyl-5-phenyl-2(1H)-pyrazinone
CAS 400087-77-6C11H10N2O2
5-(4-Chlorophenyl)-1-hydroxy-3-methyl-2(1H)-pyrazinone chemical structure, C11H9ClN2O2, CAS 400087-78-7
5-(4-Chlorophenyl)-1-hydroxy-3-methyl-2(1H)-pyrazinone
CAS 400087-78-7C11H9ClN2O2
3-(2-Methylpropyl)-5-phenylpyrazin-2(1H)-one chemical structure, C14H16N2O, CAS 128972-00-9
3-(2-Methylpropyl)-5-phenylpyrazin-2(1H)-one
CAS 128972-00-9C14H16N2O
1-Hydroxy-5-[4-(trifluoromethyl)phenyl]-2(1H)-pyrazinone chemical structure, C11H7F3N2O2, CAS 866142-99-6
1-Hydroxy-5-[4-(trifluoromethyl)phenyl]-2(1H)-pyrazinone
CAS 866142-99-6C11H7F3N2O2
1-Hydroxy-3-isopropyl-5-phenyl-2(1H)-pyrazinone chemical structure, C13H14N2O2, CAS 400088-89-3
1-Hydroxy-3-isopropyl-5-phenyl-2(1H)-pyrazinone
CAS 400088-89-3C13H14N2O2
3-Ethyl-6-methyl-5-phenylpyrazin-2-ol chemical structure, C13H14N2O, CAS 786652-82-2
3-Ethyl-6-methyl-5-phenylpyrazin-2-ol
CAS 786652-82-2C13H14N2O
5-(4-Aminophenyl)pyrazin-2(1H)-one chemical structure, C10H9N3O, CAS 64606-13-9
5-(4-Aminophenyl)pyrazin-2(1H)-one
CAS 64606-13-9C10H9N3O
6-Chloro-5-phenylpyrazin-2(1H)-one chemical structure, C10H7ClN2O, CAS 64163-14-0
6-Chloro-5-phenylpyrazin-2(1H)-one
CAS 64163-14-0C10H7ClN2O
3-Bromo-5-phenylpyrazin-2(1H)-one chemical structure, C10H7BrN2O, CAS 67602-02-2
3-Bromo-5-phenylpyrazin-2(1H)-one
CAS 67602-02-2C10H7BrN2O
3-Amino-5-phenylpyrazin-2(1H)-one chemical structure, C10H9N3O, CAS 67602-03-3
3-Amino-5-phenylpyrazin-2(1H)-one
CAS 67602-03-3C10H9N3O
3-Methoxy-5-phenylpyrazin-2(1H)-one chemical structure, C11H10N2O2, CAS 67602-07-7
3-Methoxy-5-phenylpyrazin-2(1H)-one
CAS 67602-07-7C11H10N2O2
3-Oxo-6-phenyl-3,4-dihydropyrazine-2-carboxamide chemical structure, C11H9N3O2, CAS 67602-11-3
3-Oxo-6-phenyl-3,4-dihydropyrazine-2-carboxamide
CAS 67602-11-3C11H9N3O2
1-Methyl-5-phenylpyrazin-2(1H)-one chemical structure, C11H10N2O, CAS 78174-93-3
1-Methyl-5-phenylpyrazin-2(1H)-one
CAS 78174-93-3C11H10N2O
5-(3,4-Dichlorophenyl)-1,2-dihydropyrazin-2-one chemical structure, C10H6Cl2N2O, CAS 76849-78-0
5-(3,4-Dichlorophenyl)-1,2-dihydropyrazin-2-one
CAS 76849-78-0C10H6Cl2N2O
5-(4-Methoxy-phenyl)-1H-pyrazin-2-one chemical structure, C11H10N2O2, CAS 76849-79-1
5-(4-Methoxy-phenyl)-1H-pyrazin-2-one
CAS 76849-79-1C11H10N2O2
5-(4-Chlorophenyl)pyrazin-2-ol chemical structure, C10H7ClN2O, CAS 36932-77-1
5-(4-Chlorophenyl)pyrazin-2-ol
CAS 36932-77-1C10H7ClN2O
5-(4-Tolyl)-2-hydroxypyrazine chemical structure, C11H10N2O, CAS 102301-37-1
5-(4-Tolyl)-2-hydroxypyrazine
CAS 102301-37-1C11H10N2O
5-(4-Aminophenyl)-3-methylpyrazin-2(1H)-one chemical structure, C11H11N3O, CAS 89541-81-1
5-(4-Aminophenyl)-3-methylpyrazin-2(1H)-one
CAS 89541-81-1C11H11N3O
5-(4-Aminophenyl)-6-methylpyrazin-2(1H)-one chemical structure, C11H11N3O, CAS 89541-82-2
5-(4-Aminophenyl)-6-methylpyrazin-2(1H)-one
CAS 89541-82-2C11H11N3O
5-Chloro-N-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]pentanamide chemical structure, C15H16ClN3O2, CAS 89541-61-7
5-Chloro-N-[4-(5-oxo-4,5-dihydropyrazin-2-yl)phenyl]pentanamide
CAS 89541-61-7C15H16ClN3O2
4-Oxo-4-[4-(5-oxo-4,5-dihydropyrazin-2-yl)anilino]butanoic acid chemical structure, C14H13N3O4, CAS 89541-64-0
4-Oxo-4-[4-(5-oxo-4,5-dihydropyrazin-2-yl)anilino]butanoic acid
CAS 89541-64-0C14H13N3O4
5-(4-Nitrophenyl)pyrazin-2(1H)-one chemical structure, C10H7N3O3, CAS 89541-65-1
5-(4-Nitrophenyl)pyrazin-2(1H)-one
CAS 89541-65-1C10H7N3O3