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Murcko scaffold

2(1H)-Pyrimidinone, 3,4-dihydro-4-phenyl- scaffold

775 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
775
With full pages
102
Scaffold SMILES

O=C1NC=CC(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2(1H)-Pyrimidinone, 3,4-dihydro-4-phenyl- page
Murcko scaffold O=C1NC=CC(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 775 chemicals

SQ 32926 chemical structure, C16H18ClN3O4, CAS 131275-84-8
SQ 32926
CAS 131275-84-8C16H18ClN3O4
Ethyl 1,4-dihydro-2-hydroxy-6-methyl-4-phenyl-5-pyrimidinecarboxylate chemical structure, C14H16N2O3, CAS 5395-36-8
Ethyl 1,4-dihydro-2-hydroxy-6-methyl-4-phenyl-5-pyrimidinecarboxylate
CAS 5395-36-8C14H16N2O3
Methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C14H16N2O4, CAS 205999-87-7
Methyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 205999-87-7C14H16N2O4
Ethyl 6-methyl-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O3, CAS 299949-24-9
Ethyl 6-methyl-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 299949-24-9C15H18N2O3
Methyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C13H14N2O3, CAS 188780-24-7
Methyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 188780-24-7C13H14N2O3
Ethyl 4-(4-(bis(2-chloroethyl)amino)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C18H23Cl2N3O3, CAS 5966-92-7
Ethyl 4-(4-(bis(2-chloroethyl)amino)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 5966-92-7C18H23Cl2N3O3
Ethyl 6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H22N2O6, CAS 201287-92-5
Ethyl 6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 201287-92-5C17H22N2O6
RefChem:382294 chemical structure, C16H21N3O3, CAS 17994-62-6
RefChem:382294
CAS 17994-62-6C16H21N3O3
Ethyl 4-(2-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O5, CAS 286439-73-4
Ethyl 4-(2-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 286439-73-4C15H18N2O5
Ethyl 4-(2,4-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C16H20N2O5, CAS 219814-77-4
Ethyl 4-(2,4-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 219814-77-4C16H20N2O5
Ethyl 6-methyl-2-oxo-4-[2-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C15H15F3N2O3, CAS 112080-29-2
Ethyl 6-methyl-2-oxo-4-[2-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 112080-29-2C15H15F3N2O3
4-(2-CL-PH)-6-ME-2-Oxo-1,2,3,4-4H-pyrimidine-5-carboxylic acid ethyl ester chemical structure, C14H15ClN2O3, CAS 17994-63-7
4-(2-CL-PH)-6-ME-2-Oxo-1,2,3,4-4H-pyrimidine-5-carboxylic acid ethyl ester
CAS 17994-63-7C14H15ClN2O3
Ethyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O4, CAS 161374-07-8
Ethyl 4-(4-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 161374-07-8C15H18N2O4
Methyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H18N2O5, CAS 293764-10-0
Methyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 293764-10-0C15H18N2O5
Isopropyl 4-[4-(dimethylamino)phenyl]-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C18H25N3O3, CAS 300690-88-4
Isopropyl 4-[4-(dimethylamino)phenyl]-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 300690-88-4C18H25N3O3
4-Chlorobutyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C18H23ClN2O5, CAS 295344-37-5
4-Chlorobutyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 295344-37-5C18H23ClN2O5
Ethyl 4-(2-chlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C15H17ClN2O3, CAS 253328-48-2
Ethyl 4-(2-chlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 253328-48-2C15H17ClN2O3
Ethyl 4-(2-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C14H16N2O4, CAS 5948-68-5
Ethyl 4-(2-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 5948-68-5C14H16N2O4
2-(Methylsulfanyl)ethyl 4-(2-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C15H17BrN2O3S, CAS 364338-06-7
2-(Methylsulfanyl)ethyl 4-(2-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 364338-06-7C15H17BrN2O3S
2-(Methylsulfanyl)ethyl 4-(3-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C15H17FN2O3S, CAS 402603-95-6
2-(Methylsulfanyl)ethyl 4-(3-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 402603-95-6C15H17FN2O3S
2-(Ethylsulfanyl)ethyl 6-methyl-4-(3-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H22N2O3S, CAS 402516-06-7
2-(Ethylsulfanyl)ethyl 6-methyl-4-(3-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 402516-06-7C17H22N2O3S
2-(Ethylsulfanyl)ethyl 6-methyl-4-(4-methyl-3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H21N3O5S, CAS 364627-21-4
2-(Ethylsulfanyl)ethyl 6-methyl-4-(4-methyl-3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 364627-21-4C17H21N3O5S
5-Acetyl-6-methyl-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one chemical structure, C13H14N2O2, CAS 25652-50-0
5-Acetyl-6-methyl-4-phenyl-3,4-dihydro-1H-pyrimidin-2-one
CAS 25652-50-0C13H14N2O2
Butan-2-yl 6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C17H19F3N2O3, CAS 346716-76-5
Butan-2-yl 6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 346716-76-5C17H19F3N2O3