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Murcko scaffold

3,4-Dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione scaffold

5 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
5
With full pages
3
Scaffold SMILES

O=C1NCCn2ccc(=O)cc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,4-Dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione page
Murcko scaffold O=C1NCCn2ccc(=O)cc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 5 of 5 chemicals

3,4-Dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione chemical structure, C8H8N2O2, CAS 5368-43-4
3,4-Dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione
CAS 5368-43-4C8H8N2O2
1,8-Dioxo-1,3,4,8-tetrahydro-2H-pyrido(1,2-a)pyrazine-6-carboxylic acid chemical structure, C9H8N2O4, CAS 5368-42-3
1,8-Dioxo-1,3,4,8-tetrahydro-2H-pyrido(1,2-a)pyrazine-6-carboxylic acid
CAS 5368-42-3C9H8N2O4
N-(2-{7-Methoxy-1,8-dioxo-1H,2H,3H,4H,8H-pyrido[1,2-a]pyrazin-2-yl}ethyl)-2-methylpropanamide chemical structure, C15H21N3O4, CAS 1040660-29-4
N-(2-{7-Methoxy-1,8-dioxo-1H,2H,3H,4H,8H-pyrido[1,2-a]pyrazin-2-yl}ethyl)-2-methylpropanamide
CAS 1040660-29-4C15H21N3O4
N-(2-{7-Methoxy-1,8-dioxo-1H,2H,3H,4H,8H-pyrido[1,2-a]pyrazin-2-yl}ethyl)-3,3-dimethylbutanamide chemical structure, C17H25N3O4, CAS 1040660-35-2
N-(2-{7-Methoxy-1,8-dioxo-1H,2H,3H,4H,8H-pyrido[1,2-a]pyrazin-2-yl}ethyl)-3,3-dimethylbutanamide
CAS 1040660-35-2C17H25N3O4
1,8-Dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-6-carboxylic acid hydrate chemical structure, C9H10N2O5, CAS 1559059-89-0
1,8-Dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-6-carboxylic acid hydrate
CAS 1559059-89-0C9H10N2O5